DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc89Da and Phlpp

DIOPT Version :9

Sequence 1:	NP_001036718.1	Gene:	Gyc89Da / 42001	FlyBaseID:	FBgn0038435	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster

Alignment Length:	395	Identity:	72/395 - (18%)
Similarity:	128/395 - (32%)	Gaps:	143/395 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   164 VIESQN----DISGGTAGPIKLTDGPLTVIVKYRLDFDNREYMAKRVNTEAHPS--------QLK 216
            ::.|:|    |:||                 ..:|..|.:::...:..::.|.|        :..
  Fly   367 LVPSRNLKYLDLSG-----------------NLQLQVDEQQFKVCQSQSQRHWSLVDVSGNNRAA 414

  Fly   217 MPTVKLDVFLDLFPFTFVLNHDMKITHAGEKIVETWIM---HNPGANPKSFIGTHVMDLFQCRRP 278
            :||.|:              ..:.......|....|.|   ..||:.             .||:.
  Fly   415 LPTTKI--------------RQVSAQRNQNKTSGPWTMGFAETPGSG-------------DCRKL 452

  Fly   279 KDTTIDWDTLIQMRAVLF---------EFELIRTGHNRAAYD-AVLNMDFENYDEMDLNEA---- 329
                    ::.|:||..:         .||.:. |..|||.: :.|..|....::|..:.|
  Fly   453 --------SVYQLRAANYGGSDEALYGMFEALE-GRGRAAQEMSHLVPDLMKQEQMVKDSAVRDY 508

  Fly   330 QTMALAKAQEFSES-------HPVDDDESAREDEIDPATGER-----RSSQGLRSILLKGQMFYI 382
            ....|..||:...|       |..   .:....::.|...:|     .|:.||.:.|::.
  Fly   509 MKFTLLAAQQQCGSVRSAALFHLT---RTRAPSKVRPLKSKRYVLRMASTGGLDAYLIRR----- 565

  Fly   383 KDVDSLIFLCSPLIENLDELHGIGLYLNDLNPHGL-------SRELVMAGWQHCSKLEI-----M 435
               .|.:.|..|.:...|::|.:.      :||.|       ...||:...|..|.::|     .
  Fly   566 ---TSQLRLTKPDVIQKDQIHSMP------DPHVLELILSNDDEYLVVGNAQLWSVMDIDRAARE 621

  Fly   436 FEKEE------QRSDELEKSLELADS-------WKRQGD-------ELLYSMIPRPIAERMRLSE 480
            ..|||      :|..::.:|...|:|       ::..|.       ||..|:..:|....:.||.
  Fly   622 IRKEENSLLAAKRLVDIAQSFAAAESLSVIVVRFRHLGTDVDHLIRELKQSVRKKPQPVSLPLSS 686

  Fly   481 EQVCQ 485
            ..||:
  Fly   687 GSVCK 691

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Da	NP_001036718.1	HNOB	2..161	CDD:285002
		HNOBA	218..476	CDD:285003	59/318 (19%)
		CYCc	457..643	CDD:214485	9/36 (25%)
		Guanylate_cyc	485..662	CDD:278633	0/1 (0%)
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380
		LRR_8	109..169	CDD:290566
		leucine-rich repeat	111..135	CDD:275380
		leucine-rich repeat	136..158	CDD:275380
		leucine-rich repeat	159..183	CDD:275380
		leucine-rich repeat	184..209	CDD:275380
		LRR_8	205..266	CDD:290566
		leucine-rich repeat	210..230	CDD:275380
		leucine-rich repeat	232..255	CDD:275380
		LRR_RI	<256..410	CDD:238064	9/59 (15%)
		leucine-rich repeat	256..276	CDD:275380
		LRR_8	279..359	CDD:290566
		leucine-rich repeat	280..303	CDD:275380
		leucine-rich repeat	304..348	CDD:275380
		leucine-rich repeat	349..372	CDD:275380	1/4 (25%)
		PP2Cc	461..655	CDD:294085	41/211 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900