DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc89Da and Gyc32E

DIOPT Version :9

Sequence 1:	NP_001036718.1	Gene:	Gyc89Da / 42001	FlyBaseID:	FBgn0038435	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	NP_001097148.1	Gene:	Gyc32E / 34553	FlyBaseID:	FBgn0010197	Length:	1191	Species:	Drosophila melanogaster

Alignment Length:	818	Identity:	191/818 - (23%)
Similarity:	300/818 - (36%)	Gaps:	244/818 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYGM-LYESVQHYVQE-----EYGVDIW---RKVCHIIDCKHNSFKTHQIYPDK----------- 45
            :||: ||:||..||:.     ..|.||:   ..:.||.:..::|.:...:|.|.
  Fly   358 IYGLHLYDSVMIYVRAITEVLRLGGDIYDGNLVMSHIFNRSYHSIQGFDVYIDSNGDAEGNYTVI 422

  Fly    46 -LMPDIAEALSACTGESFDFCMNFFGRCFVRFFSNFGYDKMIRSTGRYFCDFLQSIDNIHLIMRF 109
             |..|:..  .|..|......|...|     ||:   |||.                  .:|..|
  Fly   423 TLQNDVGS--GASIGSLAKMSMQPVG-----FFA---YDKN------------------SVIPEF 459

  Fly   110 TYPKMKSPSMQLTNMDDNGAVILYRSSRTGMSKYLIGQMTEVAREFYGLEIKAYVIESQNDISGG 174
            .|.|...|             |.:.:.|..:::.|.|        |:                 |
  Fly   460 RYIKNDRP-------------IQWLNGRPPLAEPLCG--------FH-----------------G 486

  Fly   175 TAGPIK------LTDGPLTVIV----------KYRLD---------FDNREYMAKRVNTEAHPSQ 214
            ...|.|      |..|||..:|          .||.:         .|.::.....:....:|:.
  Fly   487 ELCPRKKLDWRYLVSGPLCALVVVVAIALLIKHYRYEQTLAGLLWKVDMKDVTVINLGEYNNPTN 551

  Fly   215 LKM-------------PTVKLDVFLDLFPFTFVL-----NHDMKITHAGEKIVETW--IMHNPGA 259
            ..:             |..:....:.||....|.     ...:.||.:..|.::..  :.|.
  Fly   552 KNIFQICRQSILVVGEPNKRSFTNIALFRGNIVAMKKIHKKSVDITRSIRKELKLMREVRHE--- 613

  Fly   260 NPKSFIGTH------VMDLFQCRR--------PKDTTIDW-------DTLIQMRAVLFEFELIRT 303
            |..:|||..      ::....|.|        .:|..:|.       ..:::....|.:.|:|..
  Fly   614 NIINFIGASTDHGSVIIFTTYCARGSLEDVLANEDLHLDHMFISSLVSDILKGMIYLHDSEIISH 678

  Fly   304 GHNRAA-----------------YDAVLNMDFENYDEMDLNEAQTMALAKAQEFSESHPVDDDES 351
            |:.|::                 ::.....:..|..|::|..|..||               .|.
  Fly   679 GNLRSSNCLIDSRWVCQISDFGLHELKAGQEEPNKSELELKRALCMA---------------PEL 728

  Fly   352 AREDEIDPATGERRSSQGLRSILLK---------GQMFYIKDVDSLIFLCSPLIENLDELHGI-- 405
            .| |...|..|.::.......|||.         |...|.|:.......|..:::     ||:
  Fly   729 LR-DAYRPGRGSQKGDVYSFGILLYEMIGRKGPWGDTAYSKEEIIQFVKCPEMLQ-----HGVFR 787

  Fly   406 -GLYLNDLNPHGLSRELVMAGW--------------QHCSKLEI------------MFEKEEQRS 443
             .|....|:.....|:.:...|              .|..:|:.            :.||.....
  Fly   788 PALTHTHLDIPDYIRKCLCQCWDEDPEVRPDIRLVRMHLKELQAGLKPNIFDNMLSIMEKYAYNL 852

  Fly   444 DEL-EKSLELADSWKRQGDELLYSMIPRPIAERMRLSEEQVCQSFEEVSVIFLEVMNVYDEGLNS 507
            :.| ::...|....|::.|.|||.|:|||:||.::..:....:.|:.|:::|.:::...:  |.:
  Fly   853 EGLVQERTNLLYEEKKKTDMLLYQMLPRPVAELLKRGDPVEAECFDCVTILFSDIVGFTE--LCT 915

  Fly   508 IQGAMQTVNTLNKVFSALDEEIISPFVYKVETVGMVYMAVSGAPDVN-PLHAEHACDLALRVMK- 570
            .....:.|..||..::..|..|.:..||||||:|..||.|||.|..| ..||.....|||.:::
  Fly   916 TSTPFEVVEMLNDWYTCCDSIISNYDVYKVETIGDAYMVVSGLPLQNGSRHAGEIASLALHLLET 980

  Fly   571 ----KFKAHDMGDVAIRVGINSGPVVAGVVGQKVPRYCLFGDTVNTASRMESSSDPWKIQLSKYT 631
                |.:......|.:|:|::|||..|||||||:||||||||||||||||||:.|..:|.:|:.|
  Fly   981 VGNLKIRHKPTETVQLRIGVHSGPCAAGVVGQKMPRYCLFGDTVNTASRMESTGDSMRIHISEAT 1045

  Fly   632 GDKVRQVG-YKVESRGTVQVKGKGDMETYWLL--EGPE 666
            ...::.:| |....||...:||||||.||||.  :.||
  Fly  1046 YQLLQVIGSYVCIERGLTSIKGKGDMRTYWLTKRQQPE 1083

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Da	NP_001036718.1	HNOB	2..161	CDD:285002	37/179 (21%)
		HNOBA	218..476	CDD:285003	62/341 (18%)
		CYCc	457..643	CDD:214485	77/192 (40%)
		Guanylate_cyc	485..662	CDD:278633	77/183 (42%)
Gyc32E	NP_001097148.1	PBP1_Speract_GC_like	44..448	CDD:107365	22/96 (23%)
		ANF_receptor	59..427	CDD:279440	17/68 (25%)
		PHA02988	534..826	CDD:165291	47/315 (15%)
		PK_GC-A_B	550..832	CDD:270944	47/305 (15%)
		HNOBA	<847..886	CDD:285003	14/38 (37%)
		CYCc	865..1057	CDD:214485	77/193 (40%)
		Guanylate_cyc	892..1076	CDD:278633	76/185 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453899
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740