DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc89Da and Ac13E

DIOPT Version :9

Sequence 1:	NP_001036718.1	Gene:	Gyc89Da / 42001	FlyBaseID:	FBgn0038435	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	NP_001259575.1	Gene:	Ac13E / 32485	FlyBaseID:	FBgn0022710	Length:	1703	Species:	Drosophila melanogaster

Alignment Length:	720	Identity:	139/720 - (19%)
Similarity:	242/720 - (33%)	Gaps:	280/720 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 YFCDFLQSIDNI----------------HLIMRFTYPKMKSP----SMQLTNMDDNGAVILYRSS 136
            ||.....||.|:                .|:|.....:|..|    ..||....|...:...|.:
  Fly   983 YFTSSTSSISNLGEVQGLGLPLAVQPPPPLLMPACSSQMADPLAACLQQLRKQSDLQLIRCVRDN 1047

  Fly   137 RTGMSKYLIG----------QMTEVAREFYGLEIKAYVIESQNDISGGTAGPIKLTDGPLTVIVK 191
            ......||:.          :..::.|:|   ..||:...::|:           |:||.|:
  Fly  1048 ARSQRSYLVKPPLRKFSLYFKSRQLERDF---RSKAHRFGAENE-----------TEGPPTL--- 1095

  Fly   192 YRLDFDNREYMAKRVNTEAHPSQLKMPTVKLDVFLDLFPFTFVLNHDMKITHAGEKIVETWIMHN 256
                      ...|.||            .:|:|:.:..:..:             .|..::|..
  Fly  1096 ----------ATPRYNT------------YIDIFVGIAVYLCI-------------SVSLFLMTQ 1125

  Fly   257 PGANP---------KSFIGTHVMDLF-----QCRRPKDTTIDWDTLIQMRAVLFEFELIRTGHNR 307
            ...:|         ..|.|..|..||     .|||...:.:.                     ||
  Fly  1126 NTVSPSFRLWVTLFSCFTGIQVFALFLFTRQMCRRQSGSNVS---------------------NR 1169

  Fly   308 AAYDAVLNMDFENYDEMDLNEAQTMALAKAQEFSESHPVDDDESAREDEIDPATGER-------- 364
            ....:..:.|.|                                  .||...|.|.|
  Fly  1170 FRSKSTTSEDLE----------------------------------RDERGAAPGGRPHFESCAD 1200

  Fly   365 RSSQGLRS---------------ILLKGQMFYIKDVDS----------LIFLCSPLIENLDELH- 403
            |..:.:.|               :||....|.:.|::.          |||:|.....|..:|:
  Fly  1201 RIFEAISSWYPWHICLAVLMAMPVLLIIANFLLLDLEQLEAFEYHYGFLIFVCIVHFCNFTQLNC 1265

  Fly   404 ---GIGLYLNDLNPHGLSRELVMAGWQHCSKLEIMFEKEEQRSDE-------------------- 445
               .:..:|..|...|::...:|. :.|        .:.:|:.|:
  Fly  1266 WVRNVLAFLAALCFIGIAVSQLMV-YSH--------NRSDQQQDQEASNFIQEIKWFQDYHVEIY 1321

  Fly   446 ------------LEKSLEL------------------ADSWKRQGDELLYSMIPRPIAERMRLSE 480
                        |.:..|:                  ..:.|.|.|.||:::||:.:||.:: :.
  Fly  1322 LDLLLILVLVWFLNREFEIGYRLTFYGNAVANQDKVRVQNMKNQADMLLHNIIPKHVAEHLK-NT 1385

  Fly   481 EQVCQSFEEVSVIFLEVMN---VYDEGLNSIQGAMQTVNTLNKVFSALDEEIISP---FVYKVET 539
            .:..::...:::||..::|   :|||   |..|..:.:..||::....||.:..|   .|.|::|
  Fly  1386 AKYSENHHNIAIIFASIVNFNEMYDE---SYLGGKEFLRVLNELIGDFDELLSRPEFRAVEKIKT 1447

  Fly   540 VGMVYMAVSGAPDVNPLHA----EH---ACDLALRVMKKFKAHDMG----DVAIRVGINSGPVVA 593
            :|..:||.||   ::|.|.    ||   ..:.::.:.:...|.:..    ::.:|:|:|.|.|.|
  Fly  1448 IGSTFMAASG---LDPSHRGTGDEHIHTLMEFSIAMQEVVDAFNKDLLEFNLILRIGMNIGDVTA 1509

  Fly   594 GVVGQKVPRYCLFGDTVNTASRMESSSDPWKIQLSK----YTGDKVRQVGYKVESRGTVQVKGKG 654
            ||:|.....|.::||.||.||||:|:..|.:||:.|    :..::     |:.|.||:|.||||.
  Fly  1510 GVIGTSKLYYDIWGDAVNVASRMDSTGLPNRIQVGKDCLPFLTNR-----YEFEPRGSVYVKGKD 1569

  Fly   655 DMETY 659
            .||.:
  Fly  1570 HMEVF 1574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Da	NP_001036718.1	HNOB	2..161	CDD:285002	17/98 (17%)
		HNOBA	218..476	CDD:285003	52/358 (15%)
		CYCc	457..643	CDD:214485	59/206 (29%)
		Guanylate_cyc	485..662	CDD:278633	60/196 (31%)
Ac13E	NP_001259575.1	CYCc	302..518	CDD:214485
		Guanylate_cyc	361..535	CDD:278633
		CYCc	1362..1556	CDD:214485	58/205 (28%)
		Guanylate_cyc	1388..1575	CDD:278633	60/198 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454023
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740