DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc89Da and GUCY2C

DIOPT Version :9

Sequence 1:	NP_001036718.1	Gene:	Gyc89Da / 42001	FlyBaseID:	FBgn0038435	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	NP_004954.2	Gene:	GUCY2C / 2984	HGNCID:	4688	Length:	1073	Species:	Homo sapiens

Alignment Length:	786	Identity:	182/786 - (23%)
Similarity:	297/786 - (37%)	Gaps:	226/786 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 FKTHQIYPDKLMPDIAEALS---ACTGESFDFCMNFFGRCFVRFFSN----FGYDKMIRSTGRYF 93
            |:.:...||.:...:...||   :....||...::...|.|...:.|    ||:...|
Human   281 FEDNVTAPDYMKNVLVLTLSPGNSLLNSSFSRNLSPTKRDFALAYLNGILLFGHMLKI------- 338

  Fly    94 CDFLQSIDNI------HLIMRFTYPKMKSPSMQLTNMDDNG-----AVILYRSSRTGMSKYLIGQ 147
              ||::.:||      |.....|:.....|    ..:||.|     .|:||.|..|...|.|:..
Human   339 --FLENGENITTPKFAHAFRNLTFEGYDGP----VTLDDWGDVDSTMVLLYTSVDTKKYKVLLTY 397

  Fly   148 MTEVAREFYGLEIKAYVIESQ-----------NDISGG------------TAGPIKLTDGPLTVI 189
            .|.|.        |.|.::..           |||:|.            |...:.|....|.::
Human   398 DTHVN--------KTYPVDMSPTFTWKNSKLPNDITGRGPQILMIAVFTLTGAVVLLLLVALLML 454

  Fly   190 VKYRLDFDNREYMAKRVNTEAHPSQLKMPTVKLDVFLDLFPF-TFVLNH-DMKI----------- 241
            .|||.|::.|:.....:..|                 ::||. |...|| .:||
Human   455 RKYRKDYELRQKKWSHIPPE-----------------NIFPLETNETNHVSLKIDDDKRRDTIQR 502

  Fly   242 ----THAGEKIVETWIMHNPG------------------ANPKSFIGTHVMD------LFQCRR- 277
                .:..::::...:.||.|                  .|...|.||..:|      :..|.|
Human   503 LRQCKYDKKRVILKDLKHNDGNFTEKQKIELNKLLQIDYYNLTKFYGTVKLDTMIFGVIEYCERG 567

  Fly   278 ------------PKDTTIDWDTLIQMRAVLFEFELIRTGHNRAAYDAVLNMDFENYDEMDLN--- 327
                        |..|.:||           ||::      ...||....|.:.:..:.:::
Human   568 SLREVLNDTISYPDGTFMDW-----------EFKI------SVLYDIAKGMSYLHSSKTEVHGRL 615

  Fly   328 -----EAQTMALAKAQEF--SESHPVDDDESAREDEIDPATGERRS---SQGL--RSILLKGQMF 380
                 ...:..:.|..:|  :...|...|.....:.:..|...::.   |.|:  :.|:|:.:.|
Human   616 KSTNCVVDSRMVVKITDFGCNSILPPKKDLWTAPEHLRQANISQKGDVYSYGIIAQEIILRKETF 680

  Fly   381 Y---IKDVDSLIFLCSPLIENLDELHGI--GLYLNDLNPHGLSRELVMAG-WQH----------- 428
            |   .:|.:..||    .:||.:.:...  .|:|.......|...|::.. |:.
Human   681 YTLSCRDRNEKIF----RVENSNGMKPFRPDLFLETAEEKELEVYLLVKNCWEEDPEKRPDFKKI 741

  Fly   429 ---CSKLEIMF--EKEEQRSDEL---------------EKSLELADSWKRQGDELLYSMIPRPIA 473
               .:|:..:|  :|.|...|.|               |:..:|..:.:.:.|.|.:.::||.:.
Human   742 ETTLAKIFGLFHDQKNESYMDTLIRRLQLYSRNLEHLVEERTQLYKAERDRADRLNFMLLPRLVV 806

  Fly   474 ERMRLSEEQVCQSFEEVSVIFLEVMNVYDEGLNSI---QGAMQTVNTLNKVFSALDEEIISPFVY 535
            :.::.......:.:|||::.|.:::     |..:|   ...|:.|:.||.::.:.|..:....||
Human   807 KSLKEKGFVEPELYEEVTIYFSDIV-----GFTTICKYSTPMEVVDMLNDIYKSFDHIVDHHDVY 866

  Fly   536 KVETVGMVYMAVSGAPDVNPLHAEHACDLA------LRVMKKFKAHDMG--DVAIRVGINSGPVV 592
            ||||:|..||..||.|..|  ...||.|:|      |..|..|:...:.  .:.||:|::|||..
Human   867 KVETIGDAYMVASGLPKRN--GNRHAIDIAKMALEILSFMGTFELEHLPGLPIWIRIGVHSGPCA 929

  Fly   593 AGVVGQKVPRYCLFGDTVNTASRMESSSDPWKIQLSKYTGD--KVRQVGYKVESRGTVQVKGKGD 655
            |||||.|:||||||||||||||||||:..|.:|.:|..|..  |..:..:..|.||...:||:|:
Human   930 AGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHVSGSTIAILKRTECQFLYEVRGETYLKGRGN 994

  Fly   656 METYWL 661
            ..||||
Human   995 ETTYWL 1000

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Da	NP_001036718.1	HNOB	2..161	CDD:285002	32/142 (23%)
		HNOBA	218..476	CDD:285003	59/363 (16%)
		CYCc	457..643	CDD:214485	70/198 (35%)
		Guanylate_cyc	485..662	CDD:278633	76/190 (40%)
GUCY2C	NP_004954.2	PBP1_GC_C_enterotoxin_receptor	35..415	CDD:107364	34/154 (22%)
		PK_GC-C	480..750	CDD:270946	46/290 (16%)
		Pkinase_Tyr	502..745	CDD:285015	40/263 (15%)
		CYCc	788..979	CDD:214485	70/197 (36%)
		Guanylate_cyc	815..1002	CDD:278633	76/193 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810