DRSC/TRiP Functional Genomics Resources

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Protein Alignment Gyc89Da and GUCY1B1

DIOPT Version :9

Sequence 1:NP_001036718.1 Gene:Gyc89Da / 42001 FlyBaseID:FBgn0038435 Length:667 Species:Drosophila melanogaster
Sequence 2:XP_011530203.1 Gene:GUCY1B1 / 2983 HGNCID:4687 Length:662 Species:Homo sapiens


Alignment Length:725 Identity:203/725 - (28%)
Similarity:327/725 - (45%) Gaps:141/725 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MYGMLYESVQHYVQEEYGVDIWRKVCHIIDCK-------HNSFKTHQIYPDKLMPDIAEALSACT 58
            |||.:..:::..|...||.::|.      |.|       ...|....||.|....|:..|.|...
Human     1 MYGFVNHALELLVIRNYGPEVWE------DIKKEAQLDEEGQFLVRIIYDDSKTYDLVAAASKVL 59

  Fly    59 GESFDFCMNFFGRCFVRFFSNFGYDKMIRSTGRYFCDFLQSIDNIHLIMRFTYPKMKSPSMQLTN 123
            ..:....:..||:.|..|....|||.::|..|....:|||::|.:|..:...||.|::||.:.|:
Human    60 NLNAGEILQMFGKMFFVFCQESGYDTILRVLGSNVREFLQNLDALHDHLATIYPGMRAPSFRCTD 124

  Fly   124 MD-DNGAVILYRSSRTGMSKYLIGQMTEVAREFYGLEIKAYVIESQNDISGGTAGPIKLTDGPLT 187
            .: ..|.::.|.|.|.|:...:||.:..||::.:|.||...||:.:|:....|         ...
Human   125 AEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIHGTEIDMKVIQQRNEECDHT---------QFL 180

  Fly   188 VIVKYRLDFDNREYMAKRVNTEAHPSQLKMPTVKLDVFLDLFPFTFVLNHDMKITHAGEKIVETW 252
            :..|...:.|..|.:.:........|::...|     |...|||..:.:.|:.:|..|..|....
Human   181 IEEKESKEEDFYEDLDRFEENGTQESRISPYT-----FCKAFPFHIIFDRDLVVTQCGNAIYRVL 240

  Fly   253 IMHNPGANPKSFIGTHVMDLFQCRRPKDTTIDWDTLIQMRAVLFEFELIRTGHNRAAYDAVLNMD 317
            ....||               .|                 ::|..|.|:|. |...::..:    
Human   241 PQLQPG---------------NC-----------------SLLSVFSLVRP-HIDISFHGI---- 268

  Fly   318 FENYDEMDLNEAQTMALAKAQEFSESHPVDDDESAREDEIDPATGERRSSQGLRSILLKGQMFYI 382
                    |:...|:.:.:::|    ..:|.::...|||:   ||..     :..:.|||||.|:
Human   269 --------LSHINTVFVLRSKE----GLLDVEKLECEDEL---TGTE-----ISCLRLKGQMIYL 313

  Fly   383 KDVDSLIFLCSPLIENLDELHGIGLYLNDLNPHGLSRELVMAGWQH------CSKLEIM------ 435
            .:.||::|||||.:.|||:|...||||:|:..|..:|:||:.|.|.      ..:|||:      
Human   314 PEADSILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFREEYKLTQELEILTDRLQL 378

  Fly   436 ----FEKEEQRSD----------ELEKSLELA--DSWKRQG--------------DELLYSMIPR 470
                .|.|::::|          :::.:|.|.  ||...:|              :.||||::|.
Human   379 TLRALEDEKKKTDTGCPARIQAFKVQTTLMLCEKDSRSTKGFPSISYSGFLLIPLNRLLYSVLPP 443

  Fly   471 PIAERMRLSEEQVCQSFEEVSVIFLEVM--NVYDEGLNSIQGAMQTVNTLNKV---FSALDEEII 530
            .:|..:|.......:.::.|:::|..::  |.:.....|.:|||:.||.||.:   |..|.:...
Human   444 SVANELRHKRPVPAKRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRK 508

  Fly   531 SPFVYKVETVGMVYMAVSGAPDVNPLHAEHACDLALRVMK---KFKAHDMGDVAIRVGINSGPVV 592
            :||||||||||..||.|||.|:....||...|.|||.:|:   :.:. |...|.|.:||::|.||
Human   509 NPFVYKVETVGDKYMTVSGLPEPCIHHARSICHLALDMMEIAGQVQV-DGESVQITIGIHTGEVV 572

  Fly   593 AGVVGQKVPRYCLFGDTVNTASRMESSSDPWKIQLSKYT-----GDKVRQVGYKVESRGTVQVKG 652
            .||:||::|||||||:|||..||.|::.:..||.:|:||     ..:.....:.:|.||.|.:||
Human   573 TGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHRGPVSMKG 637

  Fly   653 KGDMETYWLL 662
            |.:....|.|
Human   638 KKEPMQVWFL 647

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Gyc89DaNP_001036718.1 HNOB 2..161 CDD:285002 46/166 (28%)
HNOBA 218..476 CDD:285003 71/299 (24%)
CYCc 457..643 CDD:214485 74/212 (35%)
Guanylate_cyc 485..662 CDD:278633 74/189 (39%)
GUCY1B1XP_011530203.1 HNOB 2..166 CDD:311572 47/169 (28%)
HNOBA 207..449 CDD:311573 71/303 (23%)
Guanylate_cyc 455..648 CDD:306677 75/194 (39%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S4189
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D245586at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.770

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