Protein Alignment Gyc89Da and GUCY1A1

DIOPT Version :10

• Sequence 1: NP_001036718.1
• Gene: Gyc89Da / 42001
• FlyBaseID: FBgn0038435
• Length: 667
• Species: Drosophila melanogaster
• Sequence 2: XP_047306103.1
• Gene: GUCY1A1 / 2982
• HGNCID: 4685
• Length: 767
• Species: Homo sapiens
• Alignment Length: 570
• Identity: 143/570 - (25%)
• Similarity: 243/570 - (42%)
• Gaps: 141/570 - (24%)

  Fly    95 DFLQSIDNI-----HLIMRFTYPKMKSPSMQLTNMDDNGAVILYRSSRTGMSKYLIGQMTEVARE 154
            |||.|...:     |........:::..|:...:.:|:...:.|...:...|..|.|.:...|..
Human   238 DFLNSFSTLLKQSSHCQEAGKRGRLEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHV 302

  Fly   155 FYGLEIKAYVIES--QNDISGGTAGPIKLTDGPLTVIVKYRLDFDNREYMAKRVNTEA-----HP 212
            .|..|::..::..  .||.|                      :|.|:.|:...|:.::     .|
Human   303 LYETEVEVSLMPPCFHNDCS----------------------EFVNQPYLLYSVHMKSTKPSLSP 345

  Fly   213 SQ----LKMPTVKLDVFLDLFPFTFVLNHDMKITHAGEKIVETWIMHNPGANPKSFIG-THVMDL 272
            |:    |.:||   .:|...|||.|:.:.||.|...|..|...       .|.:.|.| .:..:.
Human   346 SKPQSSLVIPT---SLFCKTFPFHFMFDKDMTILQFGNGIRRL-------MNRRDFQGKPNFEEY 400

  Fly   273 FQCRRPKDTTIDWDTLIQMRAVLFEFELIRTGHNRAAYDAVLNMDFENYDEMDLNEAQTMALAKA 337
            |:...||              :...|..|.|         :|||.|               :.:.
Human   401 FEILTPK--------------INQTFSGIMT---------MLNMQF---------------VVRV 427

  Fly   338 QEFSESHPVDDDESAREDEIDPATGERRSSQGLRSILLKGQMFYIKDVDSLIFLCSPLIENLDEL 402
            :.:..|                   .::||   |.:.|||||.||.:..:::||.||.::.|::.
Human   428 RRWDNS-------------------VKKSS---RVMDLKGQMIYIVESSAILFLGSPCVDRLEDF 470

  Fly   403 HGIGLYLNDLNPHGLSRELVMAGWQHCSKLEIMFEKEEQRSDELEKSLELA----DSWKRQGDEL 463
            .|.||||:|:..|...|::|:.|.|..::     :..::|..:|:.:||.|    :..|::..:|
Human   471 TGRGLYLSDIPIHNALRDVVLIGEQARAQ-----DGLKKRLGKLKATLEQAHQALEEEKKKTVDL 530

  Fly   464 LYSMIPRPIAERMRLSEEQVCQSFEEVSVIFLEVMNVYDEGLNSI---QGAMQTVNTLNKVFSAL 525
            |.|:.|..:|:::...:....:.|..|:::|.:::     |..:|   ...:|.:..||.:::..
Human   531 LCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIV-----GFTAICSQCSPLQVITMLNALYTRF 590

  Fly   526 DEEIISPFVYKVETVGMVYMAVSGAPDVNPLHAE---HACDLALRVMKKFKAHD-----MGD-VA 581
            |::.....||||||:|..|....|      ||.|   ||..:||..:|..:..|     .|: :.
Human   591 DQQCGELDVYKVETIGDAYCVAGG------LHKESDTHAVQIALMALKMMELSDEVMSPHGEPIK 649

  Fly   582 IRVGINSGPVVAGVVGQKVPRYCLFGDTVNTASRMESSSDPWKIQLSKYT 631
            :|:|::||.|.|||||.|:|||||||:.|..|::.||.|.|.||.:|..|
Human   650 MRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTT 699

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Da	NP_001036718.1	HNOB	2..161	CDD:462233	14/70 (20%)
		HNOBA	218..476	CDD:462234	63/262 (24%)
		Nucleotidyl_cyc_III	485..662	CDD:448371	56/159 (35%)
GUCY1A1	XP_047306103.1	HNOBA	354..543	CDD:462234	63/263 (24%)
		Guanylate_cyc	549..720	CDD:425528	56/162 (35%)