Protein Alignment Gyc89Da and GUCY1A2

DIOPT Version :10

• Sequence 1: NP_001036718.1
• Gene: Gyc89Da / 42001
• FlyBaseID: FBgn0038435
• Length: 667
• Species: Drosophila melanogaster
• Sequence 2: NP_001243353.1
• Gene: GUCY1A2 / 2977
• HGNCID: 4684
• Length: 763
• Species: Homo sapiens
• Alignment Length: 687
• Identity: 160/687 - (23%)
• Similarity: 296/687 - (43%)
• Gaps: 162/687 - (23%)

  Fly     5 LYESVQHYVQEEYGVDIWRKVCHIID--CKHNSFKTHQIYPDKLMPDIAEALSACT----GESFD 63
            |..::|:|..:..|.....|..|.|.  |   |:..|....:  :.|::..|. ||    |..|:
Human   109 LKRTLQYYEHQVIGYRDAEKNFHNISNRC---SYADHSNKEE--IEDVSGILQ-CTANILGLKFE 167

  Fly    64 FCMNFFGRCF--VRFFSNFGYDKMIRSTGRYFCDFLQSIDNIHLIMRFTYPK---MKSPSMQLTN 123
            .....||..|  :.|..|   ::::|:.|....||....|.:...:|.::.|   ::|||.....
Human   168 EIQKRFGEEFFNICFHEN---ERVLRAVGGTLQDFFNGFDALLEHIRTSFGKQATLESPSFLCKE 229

  Fly   124 MDDNGAVILYRSSRTGMSKYLIGQMTEVAREFYGLEIKAYVIESQ---NDISG-GTAGPIKLTDG 184
            :.:...::.|......:...::|.:....::.|.|:::...:.::   :|:|. |..       .
Human   230 LPEGTLMLHYFHPHHIVGFAMLGMIKAAGKKIYRLDVEVEQVANEKLCSDVSNPGNC-------S 287

  Fly   185 PLTVIVKYRLDFDNREYMAKRV--NTEAHPSQLKMPTVKLDVFLDLFPFTFVLNHDMKITHAGEK 247
            .||.::|   :.:|...| |.:  .|...|:.|:   :.::.|...|||..:.:..|.:...||
Human   288 CLTFLIK---ECENTNIM-KNLPQGTSQVPADLR---ISINTFCRAFPFHLMFDPSMSVLQLGE- 344

  Fly   248 IVETWIMHNPGANPKSFIGTHVMDLFQCRRPKDTTIDWDTLIQMRAVLFE--FELIRTGHNRAAY 310
                      |...:....||                       :.:.||  ||::....| |.:
Human   345 ----------GLRKQLRCDTH-----------------------KVLKFEDCFEIVSPKVN-ATF 375

  Fly   311 DAVLNMDFENYDEMDLNEAQTMALAKAQEFSESHPVDDDESAREDEIDPATGERRSSQGLRSILL 375
            :.||           |..:....:....|.|.|...|                       :.:.:
Human   376 ERVL-----------LRLSTPFVIRTKPEASGSENKD-----------------------KVMEV 406

  Fly   376 KGQMFYIKDVDSLIFLCSPLIENLDELHGIGLYLNDLNPHGLSRELVMAGWQHCSKLEIMFEKEE 440
            ||||.::.:.:|::||.||.::.||||.|.||:|:|:..|..:|::::.|.|  :|.:...:|
Human   407 KGQMIHVPESNSILFLGSPCVDKLDELMGRGLHLSDIPIHDATRDVILVGEQ--AKAQDGLKK-- 467

  Fly   441 QRSDELEKSLE----LADSWKRQGDELLYSMIPRPIAERMRLSEEQVCQSFEEVSVIFLEVMNVY 501
             |.|:|:.:||    ..:..|::..:||||:.|..:|:::...::...:.|::|:::|.:::
Human   468 -RMDKLKATLERTHQALEEEKKKTVDLLYSIFPGDVAQQLWQGQQVQARKFDDVTMLFSDIV--- 528

  Fly   502 DEGLNSIQG---AMQTVNTLNKVFSALDEEIISPFVYKVETVGMVYMAVSGAPDVNPLHAEHACD 563
              |..:|..   .||.::.||::::..|.:.....:|||||:|..|...:|....:..||:....
Human   529 --GFTAICAQCTPMQVISMLNELYTRFDHQCGFLDIYKVETIGDAYCVAAGLHRKSLCHAKPIAL 591

  Fly   564 LALRVMKKFK------------------------------AH----DMGDVAIRVGINSGPVVAG 594
            :||::|:..:                              .|    |:|...:|:||:||.|:||
Human   592 MALKMMELSEEVLTPDGRPIQPQRSELLFSFPVSIQLVPDQHQSETDLGTEKMRIGIHSGSVLAG 656

  Fly   595 VVGQKVPRYCLFGDTVNTASRMESSSDPWKIQLSKYT 631
            |||.::|||||||:.|..||:.||.|.|.:|.:|..|
Human   657 VVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTT 693

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Da	NP_001036718.1	HNOB	2..161	CDD:462233	35/166 (21%)
		HNOBA	218..476	CDD:462234	59/263 (22%)
		Nucleotidyl_cyc_III	485..662	CDD:448371	54/184 (29%)
GUCY1A2	NP_001243353.1	HNOB	<159..270	CDD:462233	21/113 (19%)
		HNOBA	316..503	CDD:462234	59/263 (22%)
		Guanylate_cyc	514..729	CDD:425528	54/185 (29%)