DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc89Da and Adcy8

DIOPT Version :9

Sequence 1:	NP_001036718.1	Gene:	Gyc89Da / 42001	FlyBaseID:	FBgn0038435	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	NP_058838.1	Gene:	Adcy8 / 29241	RGDID:	2036	Length:	1248	Species:	Rattus norvegicus

Alignment Length:	298	Identity:	86/298 - (28%)
Similarity:	152/298 - (51%)	Gaps:	46/298 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   406 GLYL--NDLNPHG------------LSRELVMAGWQHCSKLE----IMFEKEEQRSDELEKSLEL 452
            ||:|  ::||..|            |....::|.:.|..:||    :.|....|..:|:.:..:|
  Rat   876 GLFLSYDNLNHSGEDFLGTKEASLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKDL 940

  Fly   453 ADSWKRQGDELLYSMIPRPIA----ERMRLSEEQVCQSFEEVSVIFLEV---MNVYDEGLNSIQG 510
                :...:.:|.:::|..:|    |:.|.:||...||::.|.|:|..:   .:.|.:...:.||
  Rat   941 ----REHNENMLRNILPGHVARHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQG 1001

  Fly   511 AMQTVNTLNKVFSALDE---EIISPFVYKVETVGMVYMAVSG-APDVNPLHAE--HACDLA---- 565
             ::.:..||::.:..||   |.....:.|::|:|..|||||| :|:......:  |.|.||
  Rat  1002 -VECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGHLCALADFSL 1065

  Fly   566 --LRVMKKFKAHDMGDVAIRVGINSGPVVAGVVGQKVPRYCLFGDTVNTASRMESSSDPWKIQLS 628
              ...:::...|...:..:|:||:.|.|||||:|.|.|:|.::|.|||.||||:|:....:||:.
  Rat  1066 ALTESIQEINKHSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVP 1130

  Fly   629 KYTGDKVRQVGYKVESRGTVQVKG----KGDMETYWLL 662
            :.|...::..|:..:.||.:.|||    :|.::||:||
  Rat  1131 EETYLILKDQGFAFDYRGEIYVKGISEQEGKIKTYFLL 1168

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Da	NP_001036718.1	HNOB	2..161	CDD:285002
		HNOBA	218..476	CDD:285003	19/91 (21%)
		CYCc	457..643	CDD:214485	61/204 (30%)
		Guanylate_cyc	485..662	CDD:278633	62/195 (32%)
Adcy8	NP_058838.1	Involved in ORAI1, STIM1, PPP2CA and PPP2R1A interaction. /evidence=ECO:0000269\|PubMed:16258073, ECO:0000269\|PubMed:22494970, ECO:0000269\|PubMed:22976297	1..179
		Involved in AKAP5 and PRKAR2A interaction. /evidence=ECO:0000269\|PubMed:22976297	1..106
		Essential for CALM1 interaction. /evidence=ECO:0000269\|PubMed:16258073	38..40
		Essential for CALM1 interaction. /evidence=ECO:0000269\|PubMed:16258073	49..51
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	51..117
		AC_N	<158..397	CDD:292831
		CYCc	363..561	CDD:214485
		Guanylate_cyc	402..586	CDD:278633
		DUF1053	614..708	CDD:283888
		CYCc	941..1145	CDD:214485	61/204 (30%)
		Guanylate_cyc	970..1169	CDD:278633	64/200 (32%)
		Involved in CALM1 interaction. /evidence=ECO:0000269\|PubMed:16258073	1106..1248		23/63 (37%)
		Required for both calcium stimulation and maintenance of autoinhibition. /evidence=ECO:0000269\|PubMed:19305019	1197..1212
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1220..1248
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900