DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc89Da and Adcy10

DIOPT Version :9

Sequence 1:	NP_001036718.1	Gene:	Gyc89Da / 42001	FlyBaseID:	FBgn0038435	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	NP_766617.2	Gene:	Adcy10 / 271639	MGIID:	2660854	Length:	1614	Species:	Mus musculus

Alignment Length:	238	Identity:	61/238 - (25%)
Similarity:	100/238 - (42%)	Gaps:	48/238 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   390 FLCSPLIENLDELHGIGLYLNDLNPHGLSRELVMAGWQHCSKLEIMFEKEEQRSDELEKSLELAD 454
            ||..|...|.||.....:...|..|.|..:..:        :|..|.|.:    .|||.||:
Mouse   217 FLKPPPTFNFDEFFTKCMGFMDYYPSGDHKNFL--------RLACMLESD----PELELSLQ--- 266

  Fly   455 SWKRQGDELLYSMIPRPIAE---RMRLSEEQVCQSFEEVSVIFLEVMNVYDEGL----NSIQGAM 512
                   :.:..:|.:.|.:   |..|||      ...|:::|:.:|....:.:    ::||.|.
Mouse   267 -------KYVMEIILKQIDDKQLRGYLSE------LRPVTIVFVNLMFKEQDKVEVIGSAIQAAC 318

  Fly   513 QTVNTLNKVFSALDEEIISPFVYKVETVGMVYMAVSGAP-DVNPLHAEHACDLALRVMKKF--KA 574
            ..:.::.|||..   :|...|::   ..|..::.|.|.| :..|....||.:.|:.:. .|  :.
Mouse   319 VHITSVLKVFRG---QINKVFMF---DKGCSFLCVFGFPGEKAPDEITHALESAVDIF-DFCSQV 376

  Fly   575 HDMGDVAIRVGINSGPVVAGVVGQKV-PRYCLFGDTVNTASRM 616
            |.:..|:|  |:.||.|..|:||..| ..|.:.|..||.|:||
Mouse   377 HKIRTVSI--GVASGIVFCGIVGHTVRHEYTVIGQKVNIAARM 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Da	NP_001036718.1	HNOB	2..161	CDD:285002
		HNOBA	218..476	CDD:285003	19/88 (22%)
		CYCc	457..643	CDD:214485	44/171 (26%)
		Guanylate_cyc	485..662	CDD:278633	38/140 (27%)
Adcy10	NP_766617.2	CHD	40..214	CDD:143636
		CHD	292..461	CDD:143636	38/135 (28%)
		COG3899	485..>959	CDD:226415
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900