DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc89Da and Gucy2c

DIOPT Version :9

Sequence 1:	NP_001036718.1	Gene:	Gyc89Da / 42001	FlyBaseID:	FBgn0038435	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	NP_037302.1	Gene:	Gucy2c / 25711	RGDID:	2771	Length:	1072	Species:	Rattus norvegicus

Alignment Length:	802	Identity:	178/802 - (22%)
Similarity:	300/802 - (37%)	Gaps:	253/802 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 FKTHQIYPDKLMPDIAEALSACT-----------------GESFDFCMNFFGRCFVRFFSNFGYD 83
            |..|....|...|:..:.:...|                 .|..||.:.:.....:     ||:
  Rat   275 FSNHYFEDDTRAPEYMDNVLVLTLPPEKFIANASVSGRFPSERSDFSLAYLEGTLL-----FGH- 333

  Fly    84 KMIRSTGRYFCDFLQSIDNIHLIMRFTYPKMKSPSMQLT--------NMDDNGAV-----ILYRS 135
             |:::       ||::.:::      |.||.......||        .:||:|.:     :||.|
  Rat   334 -MLQT-------FLENGESV------TTPKFARAFRNLTFQGLEGPVTLDDSGDIDNIMCLLYVS 384

  Fly   136 SRTGMSKYLIGQMTEVAREFYGLEIKAYVIESQ---NDISGGTAGP--------------IKLTD 183
            ..|...|.|:...|...:.........::.::.   ||:.|  .||              :.|..
  Rat   385 LDTRKYKVLMAYDTHKNQTIPVATSPNFIWKNHRLPNDVPG--LGPQILMIAVFTLTGIVVVLLL 447

  Fly   184 GPLTVIVKYRLDFDNREYMAKRVNTEAHPSQLKMPTVKLDVFLDLFPF-TFVLNH-DMKI----- 241
            ..|.|:.|||.|.:.|:.....:.:|                 ::||. |...|| .:||
  Rat   448 IALLVLRKYRRDHELRQKKWSHIPSE-----------------NIFPLETNETNHVSLKIDDDRR 495

  Fly   242 ----------THAGEKIVETWIMHNPG------------------ANPKSFIGTHVMD--LF--- 273
                      .:..:|::...:.|..|                  .|...|.||..:|  :|
  Rat   496 RDTIQRVRQCKYDKKKVILKDLKHCDGNFSEKQKIELNKLLQSDYYNLTKFYGTVKLDTRIFGVV 560

  Fly   274 -QCRR-------------PKDTTIDWDTLIQMRAVLFEFELIRTGHNRAAYDAVLNMDFENYDEM 324
             .|.|             |..|.:||:         |:..::.        |....|.:.:..::
  Rat   561 EYCERGSLREVLNDTISYPDGTFMDWE---------FKISVLN--------DIAKGMSYLHSSKI 608

  Fly   325 DLN--------EAQTMALAKAQEF--SESHPVDDDESAREDEIDPATGERRS-----SQGLRSIL 374
            :::        ...:..:.|..:|  :...|...|.....:.:..||..::.     |...:.|:
  Rat   609 EVHGRLKSTNCVVDSRMVVKITDFGCNSILPPKKDLWTAPEHLRQATISQKGDVYSFSIIAQEII 673

  Fly   375 LKGQMFY---IKDVDSLIFLCSP-----------LIENLDELHGIGLYLNDLNPHGLSRELVMAG 425
            |:.:.||   .:|.:..||....           .:|..||.. :.:||           ||.:.
  Rat   674 LRKETFYTLSCRDQNEKIFRVENSYGTKPFRPDLFLETADEKE-LEVYL-----------LVKSC 726

  Fly   426 WQH--------------CSKLEIMF--EKEEQRSDEL---------------EKSLELADSWKRQ 459
            |:.              .:|:..:|  :|.|...|.|               |:..:|..:.:.:
  Rat   727 WEEDPEKRPDFKKIESTLAKIFGLFHDQKNESYMDTLIRRLQLYSRNLEHLVEERTQLYKAERDR 791

  Fly   460 GDELLYSMIPRPIAERMRLSEEQVCQS--FEEVSVIFLEVMNVYDEGLNSI---QGAMQTVNTLN 519
            .|.|.:.::||.:.:  .|.|:.:.:.  :|||::.|.:::     |..:|   ...|:.|:.||
  Rat   792 ADHLNFMLLPRLVVK--SLKEKGIVEPELYEEVTIYFSDIV-----GFTTICKYSTPMEVVDMLN 849

  Fly   520 KVFSALDEEIISPFVYKVETVGMVYMAVSGAPDVNPLHAEHACDLA------LRVMKKFKAHDMG 578
            .::.:.|:.:....||||||:|..|:..||.|..|  ...||.|::      |..|..|:...:.
  Rat   850 DIYKSFDQIVDHHDVYKVETIGDAYVVASGLPMRN--GNRHAVDISKMALDILSFMGTFELEHLP 912

  Fly   579 --DVAIRVGINSGPVVAGVVGQKVPRYCLFGDTVNTASRMESSSDPWKIQLSKYTGDKVRQVG-- 639
              .|.||:|::|||..|||||.|:||||||||||||||||||:..|.:|.:|..|...:|:..
  Rat   913 GLPVWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHMSSSTIAILRRTDCQ 977

  Fly   640 YKVESRGTVQVKGKGDMETYWL 661
            :..|.||...:||:|...||||
  Rat   978 FLYEVRGETYLKGRGTETTYWL 999

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Da	NP_001036718.1	HNOB	2..161	CDD:285002	28/154 (18%)
		HNOBA	218..476	CDD:285003	59/371 (16%)
		CYCc	457..643	CDD:214485	71/200 (36%)
		Guanylate_cyc	485..662	CDD:278633	75/192 (39%)
Gucy2c	NP_037302.1	Periplasmic_Binding_Protein_Type_1	34..414	CDD:299141	28/158 (18%)
		PKc_like	479..749	CDD:304357	46/298 (15%)
		STYKc	501..744	CDD:214568	40/271 (15%)
		CYCc	787..978	CDD:214485	71/199 (36%)
		Guanylate_cyc	814..1001	CDD:278633	75/193 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810