DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc89Da and Npr1

DIOPT Version :9

Sequence 1:	NP_001036718.1	Gene:	Gyc89Da / 42001	FlyBaseID:	FBgn0038435	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	NP_036745.1	Gene:	Npr1 / 24603	RGDID:	3195	Length:	1057	Species:	Rattus norvegicus

Alignment Length:	798	Identity:	188/798 - (23%)
Similarity:	292/798 - (36%)	Gaps:	271/798 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 IYPDKLMPDIAEALSACTGESFDFCMNFFGRCFVRFFSNF-GYDKMIRSTGRYFCDF-------- 96
            :|...:...:|:..:...||      |...|.:.|.|... ||.|:.|: |....||
  Rat   355 LYVQAVTETLAQGGTVTDGE------NITQRMWNRSFQGVTGYLKIDRN-GDRDTDFSLWDMDPE 412

  Fly    97 ----------------LQSIDNIHLIMRFTYPKMKSPSMQLTNMD-----DNGAVI--------- 131
                            |.::....|.....||....|.....|.|     |:.:.:
  Rat   413 TGAFRVVLNYNGTSQELMAVSEHKLYWPLGYPPPDVPKCGFDNEDPACNQDHFSTLEVLALVGSL 477

  Fly   132 -----------LYRSSRTGMSKYLIGQMTEVAREFYGLEIKAYVIE-------SQNDIS--GGTA 176
                       :||..:  :.|.|:.::..|..|    :::...:|       |:..:|  |...
  Rat   478 SLISFLIVSFFIYRKMQ--LEKELVSELWRVRWE----DLQPSSLERHLRSAGSRLTLSGRGSNY 536

  Fly   177 GPIKLTDGPLTVIVKYRLDFDNREYMAKRVNTEAHPSQLKMPTVKLDVFLDLFPFTFVLNH--DM 239
            |.:..|:|...|..|... :.......||||.:......|:              .|.|.|  |:
  Rat   537 GSLLTTEGQFQVFAKTAY-YKGNLVAVKRVNRKRIELTRKV--------------LFELKHMRDV 586

  Fly   240 KITHAGEKIVETWIMHNPGANPKSFIGTHVMDLFQCRRP---------------------KDTTI 283
            :..|.                 ..|:|.       |..|                     :..|:
  Rat   587 QNEHL-----------------TRFVGA-------CTDPPNICILTEYCPRGSLQDILENESITL 627

  Fly   284 DWDTLIQMRAVLFEFELIRTGHNRAAYDAVLNMDFENYDEMDLNEAQTMALAKAQEFSESHPVDD 348
            ||         :|.:.|..        |.|..|.|          ....|:........|:.|.|
  Rat   628 DW---------MFRYSLTN--------DIVKGMLF----------LHNGAICSHGNLKSSNCVVD 665

  Fly   349 D-----------ESAREDE------------------IDPATGERRSSQG---------LRSILL 375
            .           ||.|:.|                  :..|:...|.||.         |:.|.|
  Rat   666 GRFVLKITDYGLESFRDPEPEQGHTLFAKKLWTAPELLRMASPPARGSQAGDVYSFGIILQEIAL 730

  Fly   376 KGQMFYIKDVDSLIFLCSP--LIE------------------NLDEL------------------ 402
            :..:||::.:|     .||  :||                  :|:||
  Rat   731 RSGVFYVEGLD-----LSPKEIIERVTRGEQPPFRPSMDLQSHLEELGQLMQRCWAEDPQERPPF 790

  Fly   403 HGIGLYLNDLNPHGLSRELVMAGWQHCSKLEIMFEKEEQRSDELEKSLE------LADSWKRQGD 461
            ..|.|.|...|....|           :.|:.:..:.||.::.||:.:|      |.:  ||:.:
  Rat   791 QQIRLALRKFNKENSS-----------NILDNLLSRMEQYANNLEELVEERTQAYLEE--KRKAE 842

  Fly   462 ELLYSMIPRPIAERMRLSEEQVCQSFEEVSVIFLEVMNVYDEGLNSIQGAMQTVNTLNKVFSALD 526
            .|||.::|..:||:::..|....::|:.|::.|.:::..  ..|::....||.|..||.:::..|
  Rat   843 ALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGF--TALSAESTPMQVVTLLNDLYTCFD 905

  Fly   527 EEIISPFVYKVETVGMVYMAVSGAPDVN-PLHAEHACDLALRVMK-----KFKAHDMGDVAIRVG 585
            ..|.:..||||||:|..||.|||.|..| .|||.....:||.::.     :.:......:.:|:|
  Rat   906 AVIDNFDVYKVETIGDAYMVVSGLPVRNGQLHAREVARMALALLDAVRSFRIRHRPQEQLRLRIG 970

  Fly   586 INSGPVVAGVVGQKVPRYCLFGDTVNTASRMESSSDPWKIQLSKYTGDKVRQV-GYKVESRGTVQ 649
            |::|||.|||||.|:||||||||||||||||||:.:..||.||..|...:.:. |:::|.||.|:
  Rat   971 IHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFDGFELELRGDVE 1035

  Fly   650 VKGKGDMETYWLLEGPEG 667
            :||||.:.||||| |..|
  Rat  1036 MKGKGKVRTYWLL-GERG 1052

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Da	NP_001036718.1	HNOB	2..161	CDD:285002	29/169 (17%)
		HNOBA	218..476	CDD:285003	63/362 (17%)
		CYCc	457..643	CDD:214485	75/192 (39%)
		Guanylate_cyc	485..662	CDD:278633	77/183 (42%)
Npr1	NP_036745.1	PBP1_NPR_A	32..439	CDD:107380	17/90 (19%)
		ANF_receptor	50..410	CDD:279440	15/61 (25%)
		PK_GC-A_B	530..803	CDD:270944	59/343 (17%)
		TyrKc	543..797	CDD:197581	53/324 (16%)
		HNOBA	<812..857	CDD:285003	14/46 (30%)
		CYCc	836..1025	CDD:214485	74/192 (39%)
		Guanylate_cyc	863..1049	CDD:278633	79/188 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810