DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc89Da and Phlpp2

DIOPT Version :9

Sequence 1:	NP_001036718.1	Gene:	Gyc89Da / 42001	FlyBaseID:	FBgn0038435	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	NP_001116066.2	Gene:	Phlpp2 / 244650	MGIID:	2444928	Length:	1355	Species:	Mus musculus

Alignment Length:	622	Identity:	115/622 - (18%)
Similarity:	196/622 - (31%)	Gaps:	212/622 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 CFVRFFSNFGYDKMIRSTGRYFCDFLQSIDNIHLIMRFTYPKMKSPSMQLTNMDDNGAVIL---- 132
            |.:||:            |...|. :..:|.|.|...:...|.|:   ||....:...|:.
Mouse   165 CMIRFY------------GEKPCQ-MDHLDRILLSGIYNVRKGKT---QLHKWAERLVVLCGTCL 213

  Fly   133 ----YRSSRTGMSKYLI---GQMTEVAREFYGLEIKAYVIESQNDISGGTAGPIKLTDGPLTVIV 190
                .:..:||....|.   |::.||.|.             |:.::..:||....|
Mouse   214 IVSSVKDCQTGKMHILPLVGGKIEEVKRR-------------QHSLAFSSAGAQAQT-------- 257

  Fly   191 KYRLDFDN-REYMAKRVNTEAHPSQLKMPTVKLDVF-LDLFPFTFVLNHDMKITHAGEKIVETWI 253
             |.:.|:. .||...:.......|| :|.||.|..: |:..|.....:.|  ||:..       :
Mouse   258 -YHVSFETLAEYQRWQRQASKVVSQ-RMSTVDLSCYSLEEVPEHLFYSQD--ITYLN-------L 311

  Fly   254 MHNPGANPKSFIGTHVMDLFQCRRPKDTTIDWDTLIQMRAVLFEFELIRTGHNRAAYDAVLNMDF 318
            .||               ..|..||...    |||.:..    :.:.:...||:.....||..:.
Mouse   312 RHN---------------FMQLERPGGL----DTLHKFS----QLKGLNLSHNKLGLFPVLLCEI 353

  Fly   319 ENYDEMDLN---------------EAQTMAL------AKAQE-------------FSESHPVDD- 348
            ....|:.|:               ..||::|      |...|             |::...:.:
Mouse   354 STLTELSLSCNGFHDLPSQIGKLLNLQTLSLDGNGLTALPDELGNLRQLTSLGISFNDFRHIPEV 418

  Fly   349 -DESAREDEIDPATGERRSSQGLRSILLKGQMFYIKDVD-------------------------- 386
             ::....|::..| |.|.....|.::.   :|..:|.||
Mouse   419 LEKLTMLDKVAMA-GNRLEVLNLGALT---RMSQVKHVDLRMNHLKTVITENMEGNKHITHMDLR 479

  Fly   387 -------SLIFLCSPLIENLDELHGIGLYLNDLNPHGLSRELVMAGWQHCSKLEIMFEKEEQRSD 444
                   .|..|||     |::||.....|.:|...|.|...:.|.|...:.:.:........|.
Mouse   480 DNQLTDLDLSSLCS-----LEQLHCERNQLRELTLSGFSLRTLYASWNRLTAVNVYPVPSLLTSL 539

  Fly   445 ELEKS-LELADSWKRQGDEL--------LYSMIPRPIAERMRLSEEQVCQSFEE-----VSVIFL 495
            ||.:: ||....|..:..:|        |.:.:|..|...:.|.:..|..:...     |..|.|
Mouse   540 ELSQNLLECVPDWACEAKKLEILDISHNLLTEVPMRILSSLSLRKLMVGHNHIHVLPALVEHIPL 604

  Fly   496 EVMNVYDEGLNSIQGAM-----------QTVNTLNKVFSA-LDEEIISPFVYKVETVGMVYM--- 545
            ||:::....|:.:...:           .:.|:|..:.|| ..||.:|       .:.::|:
Mouse   605 EVLDIQHNTLSRLPDTLFSKALNLRYLNASANSLESLPSACAGEESLS-------VLQLLYLTSN 662

  Fly   546 --------AVSGAPDVNPLHAEHACDLALRVMKKFKA 574
                    .:.|.|.:..||      ||...::.|.|
Mouse   663 LLTDQCIPVLVGHPHLRVLH------LANNQLQTFPA 693

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Da	NP_001036718.1	HNOB	2..161	CDD:285002	20/99 (20%)
		HNOBA	218..476	CDD:285003	60/336 (18%)
		CYCc	457..643	CDD:214485	28/154 (18%)
		Guanylate_cyc	485..662	CDD:278633	22/118 (19%)
Phlpp2	NP_001116066.2	PH_PHLPP-like	181..275	CDD:270131	23/118 (19%)
		leucine-rich repeat	285..305	CDD:275380	5/19 (26%)
		leucine-rich repeat	306..332	CDD:275380	10/55 (18%)
		LRR_RI	309..548	CDD:238064	46/277 (17%)
		LRR_8	354..412	CDD:290566	8/57 (14%)
		leucine-rich repeat	356..378	CDD:275380	2/21 (10%)
		leucine-rich repeat	379..401	CDD:275380	5/21 (24%)
		leucine-rich repeat	402..424	CDD:275380	1/21 (5%)
		LRR_8	425..483	CDD:290566	9/61 (15%)
		leucine-rich repeat	425..448	CDD:275380	6/26 (23%)
		LRR_RI	447..714	CDD:238064	50/265 (19%)
		leucine-rich repeat	449..472	CDD:275380	3/22 (14%)
		leucine-rich repeat	474..493	CDD:275380	2/18 (11%)
		leucine-rich repeat	494..513	CDD:275380	6/18 (33%)
		leucine-rich repeat	514..535	CDD:275380	2/20 (10%)
		LRR_8	536..592	CDD:290566	12/55 (22%)
		leucine-rich repeat	536..558	CDD:275380	6/21 (29%)
		leucine-rich repeat	559..581	CDD:275380	4/21 (19%)
		leucine-rich repeat	582..597	CDD:275380	2/14 (14%)
		LRR_8	604..664	CDD:290566	12/66 (18%)
		leucine-rich repeat	604..627	CDD:275380	4/22 (18%)
		leucine-rich repeat	628..653	CDD:275380	7/31 (23%)
		leucine-rich repeat	654..677	CDD:275380	2/22 (9%)
		LRR_8	676..735	CDD:290566	7/24 (29%)
		leucine-rich repeat	678..701	CDD:275380	6/22 (27%)
		leucine-rich repeat	702..724	CDD:275380
		leucine-rich repeat	747..768	CDD:275380
		PP2Cc	816..1065	CDD:238083
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900