DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc89Da and Gucy1b2

DIOPT Version :9

Sequence 1:	NP_001036718.1	Gene:	Gyc89Da / 42001	FlyBaseID:	FBgn0038435	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	XP_011243363.2	Gene:	Gucy1b2 / 239134	MGIID:	2660873	Length:	829	Species:	Mus musculus

Alignment Length:	724	Identity:	187/724 - (25%)
Similarity:	335/724 - (46%)	Gaps:	145/724 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYGMLYESVQHYVQEEYGVDIWRKVCHIIDCKHNSFKTHQIYPD----KLMPDIAEALSACTGES 61
            |||.:...:|..|.|::|.:.|.|:....:.: :.|.|:.:|.|    ||:.:..:||..    |
Mouse   114 MYGFINTCLQSLVTEKFGEETWEKLKASAEVQ-DVFMTYTVYDDTITVKLIQEACKALDV----S 173

  Fly    62 FDFCMNFFGRCFVRFFSNFGYDKMIRSTGRYFCDFLQSIDNIHLIMRFTYPKMKSPSMQLTNMDD 126
            .:..:..||..|.:|....|||:|:|:.|....:|::::|.:|..:..:|.:|.:||.::....|
Mouse   174 MEAILKLFGEYFFKFCKMSGYDRMLRTLGGNLTEFIENLDALHSYLALSYQEMNAPSFRVEGGAD 238

  Fly   127 NGAVILYRSSRTGMSKYLIGQMTEVAREFYGLEIKAYVIESQNDI--SGGTAGPIKLTDGPLTVI 189
            ....:.|.|.|.|:...:.|.:..||::|:..::...:::...::  :|.....:.|      |:
Mouse   239 GAMRLHYYSDRRGLCHIVPGIIEAVAKDFFDTDVAMSILDMNEEVERTGKKEHVVFL------VV 297

  Fly   190 VKYRLDF---------DNREYMAKRVNTE--------------------AHPSQLKMPT------ 219
            .|.|...         |:....||:.:.:                    :|.:.::...
Mouse   298 QKARRQIRGAKVNRPRDSENIQAKQESLQGTLLRKKERYLSIPVCPGEKSHSAVVRASVLLGKGP 362

  Fly   220 --------------VKLDVFLDLFPFTFVLNHDMKITHAGEKIVETWIMHNPGANPKSFIGTHVM 270
                          ::.:||.:.|||..|.:..:::..||..|.:    :.||...:.|   .:.
Mouse   363 LGDTFQPVFPERLWIEEEVFCNAFPFHVVFDEALRVKQAGVNIQK----YVPGILTQKF---GLD 420

  Fly   271 DLFQCRRPKDTTIDWDTLIQMRAVLFEFELIRTGHNRAAYDAVLNMDFENYDEMDLNEAQTMALA 335
            :.|....|:.|                       .|.::....:|..|               :.
Mouse   421 EYFSIVHPQVT-----------------------FNISSICKFINSQF---------------IL 447

  Fly   336 KAQEFSESHPVDDDESAREDEIDPATGERRSSQGLRSILLKGQMFYIKDVDSLIFLCSPLIENLD 400
            |.:.                |:.|   |...||  .::.|:|||.:::.:..::|:|||.:.:|.
Mouse   448 KTRR----------------EMMP---EAWKSQ--PTLKLRGQMIWMESLKCMVFMCSPKLRSLQ 491

  Fly   401 ELHGIGLYLNDLNPHGLSRELVMAGWQHCSKLEIMFEKEEQRSDELEKSLELADSWKRQGDELLY 465
            ||....::|:|:.||..:|:|::...|..:::|:..:.|:::.:....|..||.. |::.:.|||
Mouse   492 ELEESKMHLSDIAPHDTTRDLILLNQQRLAEMELSCQLEKKKEELRVLSNHLAIE-KKKTETLLY 555

  Fly   466 SMIPRPIAERMRLSEEQVCQSFEEVSVIFLEVMNVYDEGLNSIQGA---MQTVNTLNKVFSALDE 527
            :|:|..:|.:::..::.....||..:::|.:|:.     ..:|..|   :|.||.||.::|..|.
Mouse   556 AMLPEHVANQLKEGKKVAAGEFETCTILFSDVVT-----FTNICAACEPIQIVNMLNSMYSKFDR 615

  Fly   528 EIISPFVYKVETVGMVYMAVSGAPDVNPLHAEHACDLAL--RVMKKFKAHDM-GD-VAIRVGINS 588
            ......||||||:|..||.|.|.|.....||:...:.||  |:..|...:.: |: :.|||||::
Mouse   616 LTNIHDVYKVETIGDAYMVVGGVPVPVESHAQRVANFALGMRISAKEVMNPVTGEPIQIRVGIHT 680

  Fly   589 GPVVAGVVGQKVPRYCLFGDTVNTASRMESSSDPWKIQLSKYTGDKVRQVGYKVESRGTVQVKGK 653
            |||:|||||.|:||||||||||||||||||...|.|:.||......:...|:::.:||.::||||
Mouse   681 GPVLAGVVGDKMPRYCLFGDTVNTASRMESHGLPNKVHLSPTAHRALENKGFEIVTRGEIEVKGK 745

  Fly   654 GDMETYWLL 662
            |.|.||:|:
Mouse   746 GKMTTYFLI 754

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Da	NP_001036718.1	HNOB	2..161	CDD:285002	43/162 (27%)
		HNOBA	218..476	CDD:285003	54/277 (19%)
		CYCc	457..643	CDD:214485	76/192 (40%)
		Guanylate_cyc	485..662	CDD:278633	79/183 (43%)
Gucy1b2	XP_011243363.2	HNOB	115..276	CDD:400167	43/165 (26%)
		HNOBA	380..566	CDD:400168	54/252 (21%)
		Guanylate_cyc	572..754	CDD:306677	79/186 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245586at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	5	4.780