DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc89Da and PHLPP1

DIOPT Version :9

Sequence 1:	NP_001036718.1	Gene:	Gyc89Da / 42001	FlyBaseID:	FBgn0038435	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	NP_919431.2	Gene:	PHLPP1 / 23239	HGNCID:	20610	Length:	1717	Species:	Homo sapiens

Alignment Length:	589	Identity:	109/589 - (18%)
Similarity:	185/589 - (31%)	Gaps:	225/589 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 CFVRFFS----NFGYDKMIRSTGRYFCDFLQSIDNIHLIMRFTYPKMKSPSMQL-TNMDDNGAVI 131
            |.:||::    :.|..:.|:.:|.|                    .::...||| .|......||
Human   519 CLIRFYAGKPHSTGSSERIQLSGMY--------------------NVRKGKMQLPVNRWTRRQVI 563

  Fly   132 L---------YRSSRTGMSKY--LIGQMTEVAREFYGLEIKAYVIESQNDISGGTAGPIKLTDGP 185
            |         .:.|.||....  |||...|        |:|.:    |:.::..::||...|
Human   564 LCGTCLIVSSVKDSLTGKMHVLPLIGGKVE--------EVKKH----QHCLAFSSSGPQSQT--- 613

  Fly   186 LTVIVKYRLDFDN-REYM--AKRVNTEAHPSQLKMPTVKLD-VFLDLFPFTFVLNHDMKITHAGE 246
                  |.:.||. .||:  .::|:..|  || ::.:|.|. ..|:..|.....:.|  :||...
Human   614 ------YYICFDTFTEYLRWLRQVSKVA--SQ-RISSVDLSCCSLEHLPANLFYSQD--LTHLNL 667

  Fly   247 KIVETWIMHNPGANPKSFIGTHVMDLFQCRRPKDTTIDWDTLIQMRAVLFEFELIRTGHNRAAYD 311
            |  :.::..||                             :|...|.
Human   668 K--QNFLRQNP-----------------------------SLPAARG------------------ 683

  Fly   312 AVLNMDFENYDEMDLNEAQTMALAKAQEFSESH----PVDDDESAREDEIDPATGERRS------ 366
                          |||.|.....|:...|.:|    |:.........|::.:....||
Human   684 --------------LNELQRFTKLKSLNLSNNHLGDFPLAVCSIPTLAELNVSCNALRSVPAAVG 734

  Fly   367 -SQGLRSILLKGQMFYIKDVDSLIFLCSPLIENLDELHGIGLYLNDLN--PHGLSR-----ELVM 423
             ...|::.||.|........:         :||:.:|..:||..|:..  |..|.:     :|.|
Human   735 VMHNLQTFLLDGNFLQSLPAE---------LENMKQLSYLGLSFNEFTDIPEVLEKLTAVDKLCM 790

  Fly   424 AG-------------WQHCSKLEIMFEK-EEQRSDELE-----KSLELADSWKRQGDELLYSMIP 469
            :|             ..|...:::.... .:..:||::     ..|:|.|:.....|.::::.|.
Human   791 SGNCVETLRLQALRKMPHIKHVDLRLNVIRKLIADEVDFLQHVTQLDLRDNKLGDLDAMIFNNIE 855

  Fly   470 RPIAERMRLSEEQVCQSFEEVSVIFLEVMNVYDEGLNSIQGAMQTVNTLNKVFSALDEEIISPFV 534
            ....||.:|....:|..|                               .|...|...|::...|
Human   856 VLHCERNQLVTLDICGYF-------------------------------LKALYASSNELVQLDV 889

  Fly   535 YKVETVGMVYMAVSGAPDVNPLH--AEHACDLALRVMKKFKAHDMG-----DVAIRVGINSG--P 590
            |.|... :.||.||.    |.|.  .|..|:     .:|.:..|:|     ::..|:..||.  .
Human   890 YPVPNY-LSYMDVSR----NRLENVPEWVCE-----SRKLEVLDIGHNQICELPARLFCNSSLRK 944

  Fly   591 VVAG 594
            ::||
Human   945 LLAG 948

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Da	NP_001036718.1	HNOB	2..161	CDD:285002	22/104 (21%)
		HNOBA	218..476	CDD:285003	47/295 (16%)
		CYCc	457..643	CDD:214485	29/147 (20%)
		Guanylate_cyc	485..662	CDD:278633	23/119 (19%)
PHLPP1	NP_919431.2	leucine-rich repeat	1107..1129	CDD:275380
		PP2Cc	1168..1420	CDD:214625
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1458..1510
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1673..1717
		PDZ-binding, required for interaction with SLC9A3R1. /evidence=ECO:0000269\|PubMed:21804599	1715..1717
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	41..118
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	136..156
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	252..470
		PH_PHLPP-like	535..631	CDD:270131	28/136 (21%)
		PH	555..636	CDD:278594	24/103 (23%)
		LRR_RI	625..929	CDD:238064	72/421 (17%)
		LRR_8	638..703	CDD:290566	18/129 (14%)
		LRR 1	638..659		4/20 (20%)
		leucine-rich repeat	641..661	CDD:275380	4/19 (21%)
		LRR 2	661..682		7/53 (13%)
		leucine-rich repeat	662..692	CDD:275380	11/92 (12%)
		LRR 3	692..712		4/19 (21%)
		leucine-rich repeat	693..738	CDD:275380	7/44 (16%)
		LRR_8	714..770	CDD:290566	12/64 (19%)
		LRR 4	715..736		3/20 (15%)
		LRR 5	738..760		6/30 (20%)
		leucine-rich repeat	739..761	CDD:275380	6/30 (20%)
		LRR 6	761..783		6/21 (29%)
		leucine-rich repeat	762..784	CDD:275380	6/21 (29%)
		LRR 7	784..804		3/19 (16%)
		leucine-rich repeat	785..808	CDD:275380	3/22 (14%)
		LRR 8	808..831		3/22 (14%)
		leucine-rich repeat	810..832	CDD:275380	2/21 (10%)
		LRR_RI	814..1074	CDD:238064	34/176 (19%)
		LRR 9	832..853		4/20 (20%)
		leucine-rich repeat	833..853	CDD:275380	4/19 (21%)
		leucine-rich repeat	854..895	CDD:275380	12/71 (17%)
		LRR 10	873..894		7/51 (14%)
		LRR 11	895..916		8/30 (27%)
		leucine-rich repeat	896..918	CDD:275380	8/30 (27%)
		LRR 12	918..939		4/20 (20%)
		leucine-rich repeat	919..941	CDD:275380	4/21 (19%)
		LRR 13	941..962		2/8 (25%)
		leucine-rich repeat	942..963	CDD:275380	2/7 (29%)
		LRR_8	962..1024	CDD:290566
		LRR 14	963..984
		leucine-rich repeat	964..987	CDD:275380
		LRR 15	987..1008
		leucine-rich repeat	988..1011	CDD:275380
		LRR 16	1013..1033
		LRR_8	1014..1072	CDD:290566
		leucine-rich repeat	1014..1037	CDD:275380
		LRR 17	1037..1058
		leucine-rich repeat	1038..1061	CDD:275380
		LRR 18	1061..1082
		Interaction with SLC9A3R1. /evidence=ECO:0000269\|PubMed:21804599	1076..1205
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900