DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc89Da and PHLPP2

DIOPT Version :9

Sequence 1:	NP_001036718.1	Gene:	Gyc89Da / 42001	FlyBaseID:	FBgn0038435	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	NP_055835.2	Gene:	PHLPP2 / 23035	HGNCID:	29149	Length:	1323	Species:	Homo sapiens

Alignment Length:	581	Identity:	104/581 - (17%)
Similarity:	183/581 - (31%)	Gaps:	195/581 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 FFSNFGYDK---------------MIRSTGRYFCDFLQSIDNIHLIMRFTYPKMKSPSMQLTNMD 125
            :.|..|:|.               |||..|...| .:..:|.|.|...:...|.|:   ||....
Human   110 YLSRLGFDDPVRIQEEATNPDLGCMIRFYGEKPC-HMDRLDRILLSGIYNVRKGKT---QLHKWA 170

  Fly   126 DNGAVIL--------YRSSRTGMSKYLI---GQMTEVAREFYGLEIKAYVIESQNDISGGTAGPI 179
            :...|:.        .:..:||....|.   |::.||.|..|.|...:...::|.
Human   171 ERLVVLCGTCLIVSSVKDCQTGKMHILPLVGGKIEEVKRRQYSLAFSSAGAQAQT---------- 225

  Fly   180 KLTDGPLTVIVKYRLDFDN-REYMAKRVNTEAHPSQLKMPTVKLDVF-LDLFPFTFVLNHDMKIT 242
                        |.:.|:. .||...:.......|| ::.||.|..: |:..|.....:.|  ||
Human   226 ------------YHVSFETLAEYQRWQRQASKVVSQ-RISTVDLSCYSLEEVPEHLFYSQD--IT 275

  Fly   243 HAGEKIVETWIMHNPGANPKSFIGTHVMDLFQCRRPKDTTIDWDTLIQMRAVLFEFELIRTGHNR 307
            :..       :.||               ..|..||...    |||.:..    :.:.:...||:
Human   276 YLN-------LRHN---------------FMQLERPGGL----DTLYKFS----QLKGLNLSHNK 310

  Fly   308 AAYDAVLNMDFENYDEMDLN---------------EAQTMALAKAQEFSESHPVDDDESAREDEI 357
            .....:|..:.....|::|:               ..||:.|  ...|..:.|   :|.....::
Human   311 LGLFPILLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCL--DGNFLTTLP---EELGNLQQL 370

  Fly   358 D------------PATGERRSSQGLRSILLKG------------QMFYIKDVD-SLIFLCSPLIE 397
            .            |...|:.:.  |..:::.|            :|.:||.|| .:..|.:.:||
Human   371 SSLGISFNNFSQIPEVYEKLTM--LDRVVMAGNCLEVLNLGVLNRMNHIKHVDLRMNHLKTMVIE 433

  Fly   398 NLD---ELHGIGLYLNDLNPHGLS---------------RELVMAGWQHCSKLEIMFEKEEQRS- 443
            ||:   .:..:.|..|.|....||               |||.::|:    .|..::....:.:
Human   434 NLEGNKHITHVDLRDNRLTDLDLSSLCSLEQLHCGRNQLRELTLSGF----SLRTLYASSNRLTA 494

  Fly   444 -------------DELEKSLELADSWKRQGDEL--------LYSMIPRPIAERMRLSEEQVCQSF 487
                         |.....||....|..:..::        |.:.:|..|...:.|.:..:..:.
Human   495 VNVYPVPSLLTFLDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEVPVRILSSLSLRKLMLGHNH 559

  Fly   488 EE-----VSVIFLEVMNVYDEGLNSIQGAM-----------QTVNTLNKVFSA-LDEEIIS 531
            .:     |..|.|||:::....|..:...:           .:.|:|..:.|| ..||.:|
Human   560 VQNLPTLVEHIPLEVLDLQHNALTRLPDTLFSKALNLRYLNASANSLESLPSACTGEESLS 620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Da	NP_001036718.1	HNOB	2..161	CDD:285002	25/110 (23%)
		HNOBA	218..476	CDD:285003	58/338 (17%)
		CYCc	457..643	CDD:214485	17/100 (17%)
		Guanylate_cyc	485..662	CDD:278633	13/64 (20%)
PHLPP2	NP_055835.2	PH_PHLPP-like	149..243	CDD:270131	22/118 (19%)
		LRR 1	250..271		5/20 (25%)
		leucine-rich repeat	253..273	CDD:275380	5/19 (26%)
		LRR 2	273..296		10/50 (20%)
		leucine-rich repeat	274..300	CDD:275380	10/55 (18%)
		LRR 3	300..321		3/20 (15%)
		leucine-rich repeat	301..323	CDD:275380	3/21 (14%)
		LRR_RI	313..606	CDD:238064	48/303 (16%)
		LRR_8	322..380	CDD:290566	8/62 (13%)
		LRR 4	323..344		2/20 (10%)
		leucine-rich repeat	324..346	CDD:275380	2/21 (10%)
		LRR 5	346..368		6/26 (23%)
		leucine-rich repeat	347..369	CDD:275380	6/26 (23%)
		LRR 6	369..390		2/20 (10%)
		leucine-rich repeat	370..416	CDD:275380	5/47 (11%)
		LRR 7	392..412		2/21 (10%)
		LRR 8	416..439		9/22 (41%)
		leucine-rich repeat	418..440	CDD:275380	8/21 (38%)
		LRR 9	440..460		5/19 (26%)
		leucine-rich repeat	442..461	CDD:275380	5/18 (28%)
		LRR 10	461..480		3/18 (17%)
		leucine-rich repeat	462..481	CDD:275380	4/22 (18%)
		LRR 11	481..502		1/20 (5%)
		leucine-rich repeat	482..503	CDD:275380	1/20 (5%)
		LRR 12	503..524		4/20 (20%)
		leucine-rich repeat	504..526	CDD:275380	4/21 (19%)
		LRR 13	526..547		3/20 (15%)
		leucine-rich repeat	527..549	CDD:275380	3/21 (14%)
		LRR_8	549..606	CDD:290566	8/56 (14%)
		LRR 14	549..570		2/20 (10%)
		leucine-rich repeat	550..565	CDD:275380	1/14 (7%)
		LRR 15	571..592		4/20 (20%)
		leucine-rich repeat	572..595	CDD:275380	4/22 (18%)
		LRR 16	595..616		4/20 (20%)
		leucine-rich repeat	596..645	CDD:275380	7/25 (28%)
		LRR 17	621..644		104/581 (18%)
		LRR_8	645..703	CDD:290566
		LRR_4	645..685	CDD:289563
		LRR 18	645..666
		leucine-rich repeat	646..669	CDD:275380
		LRR 19	669..690
		leucine-rich repeat	670..692	CDD:275380
		LRR 20	692..713
		leucine-rich repeat	693..714	CDD:275380
		LRR 21	714..735
		leucine-rich repeat	715..734	CDD:275380
		LRR 22	737..758
		leucine-rich repeat	738..764	CDD:275380
		PP2Cc	784..1033	CDD:238083
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1060..1157
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1285..1323
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900