DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc89Da and Npr2

DIOPT Version :9

Sequence 1:	NP_001036718.1	Gene:	Gyc89Da / 42001	FlyBaseID:	FBgn0038435	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	NP_776149.1	Gene:	Npr2 / 230103	MGIID:	97372	Length:	1047	Species:	Mus musculus

Alignment Length:	423	Identity:	129/423 - (30%)
Similarity:	207/423 - (48%)	Gaps:	86/423 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   298 FELIRTGHNRAAYDAVLNMDFENYDEMDLNEAQTMALAKAQEFSESHPVDDDESAREDEIDPATG 362
            |.|..|.:..|::.:....|       |.:......|..|.|....:|:            |.||
Mouse   656 FVLKITDYGLASFRSTAEPD-------DSHALYAKKLWTAPELLSGNPL------------PTTG 701

  Fly   363 ERRSSQG-----LRSILLKGQMFYIKDVDSLIFLCSP--LIENLDELHGIGLYLN-DLNPHGLSR 419
            .:::...     |:.|.|:...||::.:|     .||  :::.:  .:|...|.. .::...|:.
Mouse   702 MQKADVYSFAIILQEIALRSGPFYLEGLD-----LSPKEIVQKV--RNGQRPYFRPSIDRTQLNE 759

  Fly   420 ELVMAGWQHC---------------------------SKLEIMFEKEEQRSDELEKSLE------ 451
            |||:. .:.|                           |.|:.:..:.||.::.|||.:|
Mouse   760 ELVLL-MERCWAQDPTERPDFGQIKGFIRRFNKEGGTSILDNLLLRMEQYANNLEKLVEERTQAY 823

  Fly   452 LADSWKRQGDELLYSMIPRPIAERMRLSEEQVCQSFEEVSVIFLEVMNVYDEGLNSIQGAMQTVN 516
            |.:  ||:.:.|||.::|..:||:::..|....::|:.|::.|.:::..  ..|::....||.|.
Mouse   824 LEE--KRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGF--TALSAESTPMQVVT 884

  Fly   517 TLNKVFSALDEEIISPFVYKVETVGMVYMAVSGAPDVN-PLHAEHACDLALRVMK-------KFK 573
            .||.:::..|..|.:..||||||:|..||.|||.|..| ..||.....:||.::.       :.:
Mouse   885 LLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHR 949

  Fly   574 AHDMGDVAIRVGINSGPVVAGVVGQKVPRYCLFGDTVNTASRMESSSDPWKIQLSKYTGDKVRQV 638
            .||  .:.:|:|:::|||.|||||.|:||||||||||||||||||:....||.:|..|.|.:.::
Mouse   950 PHD--QLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDEL 1012

  Fly   639 G-YKVESRGTVQVKGKGDMETYWLL---EGPEG 667
            | :::|.||.|::||||.|.|||||   :||.|
Mouse  1013 GCFQLELRGDVEMKGKGKMRTYWLLGEQKGPPG 1045

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Da	NP_001036718.1	HNOB	2..161	CDD:285002
		HNOBA	218..476	CDD:285003	45/218 (21%)
		CYCc	457..643	CDD:214485	75/194 (39%)
		Guanylate_cyc	485..662	CDD:278633	78/185 (42%)
Npr2	NP_776149.1	PBP1_NPR_B	26..421	CDD:380607
		PK_GC-A_B	518..792	CDD:270944	28/162 (17%)
		HNOBA	<798..846	CDD:369471	16/49 (33%)
		CYCc	825..1009	CDD:214485	74/189 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810