DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc89Da and gcy-37

DIOPT Version :9

Sequence 1:	NP_001036718.1	Gene:	Gyc89Da / 42001	FlyBaseID:	FBgn0038435	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	NP_500171.2	Gene:	gcy-37 / 191658	WormBaseID:	WBGene00001557	Length:	708	Species:	Caenorhabditis elegans

Alignment Length:	650	Identity:	157/650 - (24%)
Similarity:	281/650 - (43%)	Gaps:	99/650 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYGMLYESVQHYVQEEYG----VDIWRKVCHIIDCKHNSFKTHQIYPDKLMPDIAEALSACTGES 61
            |.|..:..|...:..:||    .:|.||..:..|.|   |.....|.|.....|....:...|.|
Worm     1 MIGWTHVCVSALILRKYGPEVLEEILRKAGYQEDIK---FDIQCYYDDTETMRIFRVAATVLGLS 62

  Fly    62 FDFCMNFFGRCFVRFFSNFGYDKMIRSTGRYFCDFLQSIDNIH-LIMRFTY-PKMKSPSMQLTNM 124
            .|.....:|...:......|:.||:........:||.:::::| .|.:..: .:||.|:.|....
Worm    63 VDDMWEMYGEFLITHACETGWQKMLFCMANNLQEFLDNLNSMHYFIDQIAFKSEMKGPTFQCEPF 127

  Fly   125 DDNGAVILYRSSRTGMSKYLIGQMTEVAREFYGLEIKAYVIESQNDISGGTAGPIKLTDGPLTVI 189
            .::|..:.|.|.|.|:...:.|.:.:.||..:.:::|..::|...:         :...|.:..:
Worm   128 GESGLKLHYFSFRQGLFPIVKGLVRKTARTLFEMDVKVCMLERNQE---------RRKSGMVEHV 183

  Fly   190 VKYRLDFDNREYMAKRV--------NTEAHPSQLKMPTVKLDV--FLDLFPFTFVLNHDMKITHA 244
            : :.::.|:.....||:        .||..||.....|:.:.:  |.::||:....|..|.|.|.
Worm   184 I-FSVEPDDNHRKGKRLFHKFRNTKTTENAPSFTLSSTILVGLRDFKNIFPYHVCFNKQMIIEHI 247

  Fly   245 GEKIVETWIMHNPGANPKSFIGTHVMDLFQCRRPKDTTIDWDTLIQMRAVLFEFELIRTGHNRAA 309
            |     .:::...|...|..:  .|.||.|..:|.|..:.:..::.....||.|:|  ..|::.
Worm   248 G-----IYLLREYGLENKKTL--KVSDLMQLVQPSDIQLTYKNVLSYLNTLFIFQL--KHHSKR- 302

  Fly   310 YDAVLNMDFENYDEMDLNEAQTMALAKAQEFSESHPVDDDESAREDEIDPATGERRSSQGLRSIL 374
                             ||.|                                |..|....:.::
Worm   303 -----------------NEVQ--------------------------------EGSSEAFQQPLV 318

  Fly   375 LKGQMFYIKDVDSLIFLCSPLIENLDELHGIGLYLNDLNPHGLSRELVMAGWQHCSKLEIMFEKE 439
            |||:|..|.|.:|:||:|||.:..:.::..:.||::|:..|..:|:|||.......::|:. :|.
Worm   319 LKGEMMPINDGNSIIFICSPHVTTVRDILNLKLYISDMPMHDATRDLVMLNQSRICQMELN-KKL 382

  Fly   440 EQRSDELEKSLELADSWKRQGDELLYSMIPRPIAERMRLSEEQVCQSFEEVSVIFLEVMNVYDEG 504
            |:...:::|..|..:..|.|.|.||:..:|..|||.:|.::....|.|.:.||||.::.:.:...
Worm   383 EETMKKMKKMTEELEVKKSQTDRLLFEFVPPVIAEALRAAKTVPAQEFSDCSVIFTDIPDFFTIS 447

  Fly   505 LNSIQGAMQTVNTLNKVFSALDEEIISPFVYKVETVGMVYMAVSGAPDVNPLHAEHACDLALRVM 569
            :|.  ...:.:..:..:|...|..|.....|||.::...|:.|.|.|:.|..|.|.:.:|||.::
Worm   448 VNC--SPTEIITVVTDLFHRFDRIIEKHKGYKVLSLMDSYLIVGGVPNANQYHCEDSLNLALGLL 510

  Fly   570 KKFKAHDM------GDVAIRVGINSGPVVAGVVGQKVPRYCLFGDTVNTASRMESSSDPWKIQLS 628
              |:|..:      ..|.:|:|::.||||||:|.|:.||:|:.|:|||....:.|.|.|.|:.:|
Worm   511 --FEAKQVVVPKLERSVRLRIGVHCGPVVAGIVSQQKPRFCVLGNTVNVTKSICSHSSPGKVLVS 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Da	NP_001036718.1	HNOB	2..161	CDD:285002	36/164 (22%)
		HNOBA	218..476	CDD:285003	61/259 (24%)
		CYCc	457..643	CDD:214485	57/177 (32%)
		Guanylate_cyc	485..662	CDD:278633	47/149 (32%)
gcy-37	NP_500171.2	HNOB	3..165	CDD:285002	36/164 (22%)
		HNOBA	223..419	CDD:285003	60/255 (24%)
		CYCc	400..577	CDD:214485	57/177 (32%)
		Nucleotidyl_cyc_III	425..609	CDD:299850	47/152 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245586at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.780