DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc89Da and gcy-34

DIOPT Version :9

Sequence 1:	NP_001036718.1	Gene:	Gyc89Da / 42001	FlyBaseID:	FBgn0038435	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	NP_506319.1	Gene:	gcy-34 / 191656	WormBaseID:	WBGene00001554	Length:	686	Species:	Caenorhabditis elegans

Alignment Length:	696	Identity:	189/696 - (27%)
Similarity:	321/696 - (46%)	Gaps:	101/696 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYGMLYESVQHYVQEEYGVDIWRKVCHIIDCKHNSFK------THQIYPDKLMPDIAEALSACTG 59
            |:|.::||::..|..:||.|:|.:|     .:.:.|:      .:..|.|.....:.:::|....
Worm     1 MFGFIHESIRQLVIRKYGEDVWLQV-----LERSGFENGKENIVNHYYSDTDTYVLVDSVSIVLK 60

  Fly    60 ESFDFCMNFFGRCFVRFFSNFGYDKMIRSTGRYFCDFLQSIDNIHLIMRFTYPK--MKSPSMQLT 122
            .:.|.....:|...:.:....|:|:::||.......||.::|::|..:.....|  ::.||.:..
Worm    61 VTKDQIWEMYGGFLITYSMEIGWDELVRSMSPNLKGFLDNLDSLHYFIDHVVYKANLRGPSFRCE 125

  Fly   123 NMDDNGAVILYRSSRTGMSKYLIGQMTEVAREFYGLEIKAYVIESQNDISGGTAGPIKLTDGP-- 185
            ...|...::.|.:.|.|:...:.|.:.|||:..:.|:|...|       .|.|...:.:.:|.
Worm   126 ENPDGTLMLHYFTGRPGLYHIVKGVVKEVAKLVFNLDISLVV-------QGRTQRSVHMNNGERV 183

  Fly   186 ---LTVIVKY----RLDFDNREYMAKRVNTEAHP-------SQLKMPTVKLDVFLDLFPFTFVLN 236
               :..::|.    |.|.|.....|.   |...|       ..||   |.|..|....|:.|||:
Worm   184 EEHVIFLIKNVEEPRRDSDTSTTSAL---TSVEPDFGEIIDDNLK---VSLQDFSRALPYHFVLD 242

  Fly   237 HDMKITHAGEKIVETWIMHNPGANPKSFIGTHVMDLFQCRRPKDTTIDWDTLIQMRAVLFEFELI 301
            ...::...|:::..    |.|  |.....||.::.:|:..||:
Worm   243 ESCRLVQCGDELYN----HIP--NELLQPGTPILRIFEINRPQ---------------------- 279

  Fly   302 RTGHNRAAYDAVLNMDFENYDEMDLNEAQTMALAKAQEFSESHPVDDDESAREDEIDPATGERRS 366
                        :.:||||.  .:...|..:...|.....:.|.....:..||.|::....|..|
Worm   280 ------------IPLDFENI--CNFINAVFVLQVKTSPLRKKHMNAMTKEEREQEVEAMEEEVES 330

  Fly   367 ---SQGLRSILLKGQMFYIKDVDSLIFLCSPLIENLDELHGIGLYLNDLNPHGLSRELVMAGWQH 428
               :||.. :.|||||..:.....:|:||||.:.:::||...|:.|..:..|..:|:|::...|.
Worm   331 NELTQGCH-LKLKGQMMMLSTKKHIIYLCSPYVTSINELMQFGMRLTAMPLHDATRDLILLNQQR 394

  Fly   429 CSKLEIMFEKEEQRSDELEKSLELADSWKRQGDELLYSMIPRPIAERMRLSEEQVCQSFEEVSVI 493
            .|.:|:..:. |..:::||......:..:::.|.:|..|:||.||::: ||.|.:.....|.:|:
Worm   395 LSDVEVNLQL-EANNEQLETMTHELEVERQKTDSILKDMLPRKIAKQL-LSGEHLEPCEYEATVM 457

  Fly   494 FLEVMNVYDEGLNSIQGAMQTVNTLNKVFSALDEEIISPFVYKVETVGMVYMAVSGAPDVNPLHA 558
            |.: :..:.:.:...| ....|..||:||..||..::...|||||||...||.|||.||....||
Worm   458 FCD-LPAFQQIIPVCQ-PKNIVKLLNEVFFKLDRIVVLRGVYKVETVSDSYMTVSGIPDYTSEHA 520

  Fly   559 EHACDLALRVMKKFKAHDMGD------VAIRVGINSGPVVAGVVGQKVPRYCLFGDTVNTASRME 617
            |:.|.:||.:|  ::|..:.|      ..:|:|::||.::|||||.|:|||||||:||..||:||
Worm   521 ENMCHVALGMM--WEARSVMDPVNKTPFLLRIGLHSGTIIAGVVGTKMPRYCLFGETVTLASQME 583

  Fly   618 SSSDPWKIQLSKYTGDKVRQVG-YKVESRGTVQVKGKGDMETYWLL 662
            |.....|||.|.:|..|..:.| ::...||.:.|||:||:|||:|:
Worm   584 SLGVAGKIQCSSWTYSKAMETGRFEFSPRGRINVKGRGDVETYFLM 629

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Da	NP_001036718.1	HNOB	2..161	CDD:285002	35/166 (21%)
		HNOBA	218..476	CDD:285003	60/260 (23%)
		CYCc	457..643	CDD:214485	75/192 (39%)
		Guanylate_cyc	485..662	CDD:278633	75/183 (41%)
gcy-34	NP_506319.1	HNOB	3..167	CDD:285002	36/168 (21%)
		HNOBA	224..441	CDD:285003	62/263 (24%)
		CYCc	421..609	CDD:214485	75/192 (39%)
		Guanylate_cyc	453..629	CDD:278633	75/179 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4189
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245586at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.730