Protein Alignment Gyc89Da and gcy-25

DIOPT Version :10

• Sequence 1: NP_001036718.1
• Gene: Gyc89Da / 42001
• FlyBaseID: FBgn0038435
• Length: 667
• Species: Drosophila melanogaster
• Sequence 2: NP_001294116.1
• Gene: gcy-25 / 191653
• WormBaseID: WBGene00001549
• Length: 1034
• Species: Caenorhabditis elegans
• Alignment Length: 764
• Identity: 161/764 - (21%)
• Similarity: 288/764 - (37%)
• Gaps: 231/764 - (30%)

  Fly    17 YGVDIWR--KVCHIID--------CKHNSFKT-HQIYPDK-LMPDIAEALSACTGESFDFCMNFF 69
            |.:.:||  |..|:.:        |..|..|. ::..|.. |:.|:....|.| |...:.|.:|
 Worm   346 YEMHMWRDGKAVHVANVKPRESDYCGGNMTKNCYEFLPSSPLLEDLPPYTSDC-GYDNNLCSDF- 408

  Fly    70 GRCFVRFFSNFGYDKMIRSTGRYFCDFLQSIDNIHLIMRFTYPKMKSPSMQLTNMDDNGA----- 129
               .|...:...:..::......|  :||..:  |||.:..:   :.| :...:.||||.
 Worm   409 ---HVFMIAAIVFSILLIPMAIAF--YLQRKE--HLIQQMPW---RVP-LDSISFDDNGGSLSAS 462

  Fly   130 --VILYRSSRTGMSKYLIGQMTEVAREFYGLEIKAYVIESQNDISGGTAGPIKLTDGPLTVIVKY 192
              |....::|...|....|.:.|.|           ::..|.                  |.||
 Worm   463 RRVSTISTARASYSSIFSGNVAEHA-----------IVNKQK------------------VSVK- 497

  Fly   193 RLDFDNREYMAKRVNTEAHPSQLKMPTVKLDVFLDLFPFTFVLNHDMKITHAGEKIVETW----- 252
                   .::.:|..|.:......:..:|.....::.|||.:      ..:.|.:::..|
 Worm   498 -------RHVQRRAITFSRQEMEMLNQLKYMSHTNINPFTGI------CFNQGSELIVMWQFTTR 549

  Fly   253 -------------------------IMHNPGANPKSFIGTH-VMDLFQCRRPKDTTIDWDTLIQM 291
                                     |:|.......|.|..| .:.|..|      .:|...::::
 Worm   550 YSLEDLIFVKEQKFGRNFQSTFIKHIVHGINYIHNSSIKVHGALYLSNC------VVDSYWVVKL 608

  Fly   292 -----RAVLFEFELIRTGHNRAAYDAVLNMDFENYDEMDLNEAQTMA-LAKAQE----------- 339
                 :.:|.|    ||.|...|..:..::|..:|..:.|......| |.|.:|
 Worm   609 TDFGIKGILKE----RTNHKELAPSSAFDVDAIHYKYLQLAPEHISAILEKLEEPRGTVEGDIYQ 669

  Fly   340 --------------FSE--------SHPVDDDESAREDEIDPATGERRS-SQGLRSILLKGQMF- 380
                          |:|        :|.:....:|   .:.|...|..| :..|.||:.:..::
 Worm   670 LAMCIYQILFYMRPFAERQESIKELAHLLSSQSTA---PLHPKVPEGNSFTMRLLSIIQQCWLYK 731

  Fly   381 ------YIKDVDSLI---------FLCSPLIENLDELHGIGLYLNDLNPHGLSRELVMAGWQHCS 430
                  .||..|::.         .|...:||.:||             :..:.|.::|
 Worm   732 PAARPALIKITDAVNREFGQDVKGTLIDQMIEMIDE-------------YSANLEQIVA------ 777

  Fly   431 KLEIMFEKEEQRSDELEKSLELADSWKRQGDELLYSMIPRPIAERMRLSEEQVCQSFEEVSVIFL 495
                      :|:.|||:.:.:.::       |||.::|:.:|:.:|..:..|.:....|:::.:
 Worm   778 ----------ERTRELEQDMSVTEN-------LLYQLLPKSVADSIRSGKTVVPEQHSSVTLLVV 825

  Fly   496 EV--MNVYDEGLNSIQGAMQTVNTLNKVFSALDEEIISPFVYKVETVGMVYMAVSGAPDVNPL-H 557
            :|  ...:.|....:    ..:.||.:::|:.|..:.....:|||.||..|:..||.|:::.. |
 Worm   826 DVCQFTKFCEAFIPV----HILETLQELYSSFDNIVQKNKAFKVENVGDAYLICSGIPEMSGFRH 886

  Fly   558 AEHACDLALRV---MKKFK-----AHDMGDVAIRVGINSGPVVAGVVGQKVPRYCLFGDTVNTAS 614
            ....|.::|::   ||.||     :|.:   .|::||.||.|.||::|...||:|:||||||.|.
 Worm   887 LREICKISLKLQAFMKTFKVRHRPSHTL---QIKMGITSGAVAAGILGSTAPRFCIFGDTVNMAC 948

  Fly   615 RMESSSDPWKIQLSKYTGDKVRQ--VGYKVESRGTVQVKGKGDMETYWL 661
            ||.|:.:|..||||:.|.:.:.:  ..:.:|.||.:.|||||...|:||
 Worm   949 RMASTGNPGSIQLSELTANTLMEKFPSFMLEERGMIDVKGKGACLTFWL 997

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Da	NP_001036718.1	HNOB	2..161	CDD:462233	34/162 (21%)
		HNOBA	218..476	CDD:462234	56/344 (16%)
		Nucleotidyl_cyc_III	485..662	CDD:448371	63/190 (33%)
gcy-25	NP_001294116.1	PBP1_NPR_GC-like	54..365	CDD:380575	5/18 (28%)
		Protein Kinases, catalytic domain	473..746	CDD:473864	50/328 (15%)
		HNOBA	<761..805	CDD:462234	15/79 (19%)
		CYCc	790..976	CDD:214485	59/199 (30%)