DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc89Da and gcy-23

DIOPT Version :9

Sequence 1:	NP_001036718.1	Gene:	Gyc89Da / 42001	FlyBaseID:	FBgn0038435	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	NP_500309.3	Gene:	gcy-23 / 191652	WormBaseID:	WBGene00001548	Length:	1073	Species:	Caenorhabditis elegans

Alignment Length:	407	Identity:	121/407 - (29%)
Similarity:	198/407 - (48%)	Gaps:	78/407 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   319 ENYDEMDLNEAQTM-----ALAKAQE----FSESHPVDDDESAREDEIDPA---TGERRSSQG-- 369
            |.::::.|...:|:     ....||:    :.....:.:.||.|...:|.:   ..:.|...|
Worm   664 ERWEKLGLISTETLKEGDDKSGSAQKTSLLYQPPEMLKNKESNRTRRMDQSWVKQSQARRQMGDI 728

  Fly   370 ------LRSILLKGQMF-----------YIKDVDSLIFLCSPLIENLDELHG--IGLYLN--DLN 413
                  :..||.:...|           ||:|.....   .|.:.:..::|.  :.|.|:  :.|
Worm   729 YAFGMVMHEILFRALPFPNGTNVSEVMDYIRDGTKTF---RPTVHDRTQIHPDLVALLLDCWNEN 790

  Fly   414 PH--------GLSRE--LVMAGWQHCSKLEIMFEKEEQRSDELEK-------SLELADSWKRQGD 461
            |.        .|:.|  |.:.|    |.::.|....||.::.|||       .||.|:.   :.|
Worm   791 PEVRPSIRRVRLNTENYLKVKG----SLVDQMMRMMEQYANNLEKLVAERTGMLEEANV---RAD 848

  Fly   462 ELLYSMIPRPIAERMRLSEEQVCQSFEEVSVIFLEVMNVYDEGLNSIQGA---MQTVNTLNKVFS 523
            :||..::|:.:|..:::......::|:..:|:|.:::     |..:|..:   ::.|:.||.::|
Worm   849 KLLGQLLPKYVANELKMGRSVPAKTFDMATVMFSDIV-----GFTTICSSSTPLEVVSMLNSIYS 908

  Fly   524 ALDEEIISPFVYKVETVGMVYMAVSGAPDVN-PLHAEHACDLALRVMKKFKAHDMG-----DVAI 582
            ..|:.|.....|||||:|..||.|||.|:.| ..|..:.|:.||.:|...|.:::.     .:.|
Worm   909 KFDDAINKHGSYKVETIGDAYMIVSGIPEENGNEHIRNICNTALELMLLLKTYEIPHRRNVKLRI 973

  Fly   583 RVGINSGPVVAGVVGQKVPRYCLFGDTVNTASRMESSSDPWKIQLSKYTGD-KVRQVG-YKVESR 645
            |:||::|.|.|||||...|||||||||||.||||||:|:|.|||:|:...| .||... :::..|
Worm   974 RLGIHTGTVAAGVVGLTAPRYCLFGDTVNVASRMESTSEPEKIQMSQEARDFCVRYYSEFQITLR 1038

  Fly   646 GTVQVKGKGDMETYWLL 662
            |||:.||||.:.:||||
Worm  1039 GTVEAKGKGPVTSYWLL 1055

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Da	NP_001036718.1	HNOB	2..161	CDD:285002
		HNOBA	218..476	CDD:285003	42/208 (20%)
		CYCc	457..643	CDD:214485	72/196 (37%)
		Guanylate_cyc	485..662	CDD:278633	77/187 (41%)
gcy-23	NP_500309.3	Periplasmic_Binding_Protein_Type_1	38..407	CDD:299141
		ANF_receptor	38..385	CDD:279440
		PK_GC	509..806	CDD:270894	24/144 (17%)
		HNOBA	<817..863	CDD:285003	14/48 (29%)
		CYCc	842..1035	CDD:214485	73/200 (37%)
		Guanylate_cyc	869..1056	CDD:278633	79/192 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810