DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc89Da and gcy-9

DIOPT Version :9

Sequence 1:	NP_001036718.1	Gene:	Gyc89Da / 42001	FlyBaseID:	FBgn0038435	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	NP_509897.3	Gene:	gcy-9 / 191645	WormBaseID:	WBGene00001536	Length:	1081	Species:	Caenorhabditis elegans

Alignment Length:	734	Identity:	191/734 - (26%)
Similarity:	292/734 - (39%)	Gaps:	182/734 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 KHNSFKTHQIY----PDKLMPDIAEALSAC--TGESFDFCMNFFGRCFVRFFSNFG---YDKMIR 87
            :|.:.:|.|.|    ..||.|    |:..|  ||...|:...|.|...:.|....|   |...::
Worm   430 EHVAHETIQYYWPSDSGKLPP----AVPKCGFTGAECDYRPYFIGASLLAFILTVGPLSYFIYLK 490

  Fly    88 STGRYFCDFLQSIDNIHLIMRFTYPKMK-------------SPSMQLTNMDDNGAVILYRSSRTG 139
            ...|...|....|....:.|.....|.:             |.||   |...||.:...::...|
Worm   491 QKERLLYDMTWRIPRESIKMLEGKSKSEHSLASKSQSSGSFSGSM---NSKQNGLIAAKQAVSNG 552

  Fly   140 MSKYLIGQMTEV-----------------------AREFYGLEIKAYVIESQNDI-------SGG 174
            : |..|.:..:|                       ..:|||:.     ...||:.       |.|
Worm   553 V-KLAIKRYQQVRNITFPKSELRLLKELKICENDNLNKFYGIS-----FNQQNEFIVMWVLCSRG 611

  Fly   175 TAGPIKLTDGPLTVIVKYRLDFDNREYMAKRVNTEAHPSQLKMPTVKLDVFLDLFPFTFVLNHDM 239
            :...|...| .|.:...:::.|      ||.|             ||...||...|   :|:|.|
Worm   612 SLEDILFND-ELKLGRNFQVSF------AKDV-------------VKGLNFLHTSP---LLHHGM 653

  Fly   240 --------------KITH-AGEKIVETWIMHNPGANPKSFIGTHVMDLFQCRRPKDTTIDW---D 286
                          |:|: |.|.::...:.||   ..:.||.|   |........|.|.|:   .
Worm   654 LCLQNCLVDSNWTVKLTNFATEAVIFEKLDHN---ELRPFINT---DSESADDVSDPTKDFARKK 712

  Fly   287 TLIQMRAVLFEFELIRT---GHNRA--------AYDAVLNMDFENYDEMDLNE-AQTMALAKAQE 339
            .|.|...::.|....:|   |...|        .|..:..::..:.....:|: .:|:|:|.
Worm   713 YLQQAPEIIREIVTTKTIPEGSQSADIYALGMVLYQILFRVEPFHERNKSINKLMETLAMAN--- 774

  Fly   340 FSESHPVDDDESAREDEIDPATGERRSSQGLRSILLKGQMFYIKDVDSLIFLCSPLIENLDELHG 404
                   |||:..|.......|||..:.|.|                |.|..|
Worm   775 -------DDDQLIRPTFPSSNTGEGYNLQLL----------------SCIEAC------------ 804

  Fly   405 IGLYLNDLNPH-GLSRELVMAGWQHCSK---LEIMFEKEEQRSDELEKSLE----LADSWKRQGD 461
             .|.:.::.|. ...|.:|.|..:...|   ::.|.:..|:.:..||..:.    |.:..::|.|
Worm   805 -WLEIPEMRPPIKKVRTMVNANLKSTGKGSLVDQMMKMMEEYTANLENMVRDRTALLEEAQKQAD 868

  Fly   462 ELLYSMIPRPIAERMRLSEEQVCQSFEEVSVIFLEVMNVYDEGLNSIQGAMQTVNTLNKVFSALD 526
            .||.||:|:.|||.:::.:..:.|.:...:|:|.::...  ..::|....:|.|..||.:||..|
Worm   869 RLLNSMLPKSIAEDLKIGKPVLPQLYSCATVLFSDIRGF--TRISSTSTPLQVVTFLNDMFSGFD 931

  Fly   527 EEIISPFVYKVETVGMVYMAVSGAPDVN-PLHAEHACDLALRV---MKKFK-AHDMGD-VAIRVG 585
            ..|.....|||||:|..||.|||.|..| ..||::..|:||::   :..|| ||...: :.:|:|
Worm   932 AIIAKHDAYKVETIGDAYMIVSGVPTENGNSHAQNIADVALKMRAFICNFKLAHRPEELMMVRIG 996

  Fly   586 INSGPVVAGVVGQKVPRYCLFGDTVNTASRMESSSDPWKIQLSKYTGDKVRQV--GYKVESRGTV 648
            .:||||.|||||...||||||||||||||||||:....|||:|:...:.:...  .:::..||.:
Worm   997 FHSGPVAAGVVGLAAPRYCLFGDTVNTASRMESTGVANKIQISEGAYNLLHCFFPQFQMVERGKI 1061

  Fly   649 QVKGKGDMETYWLLEGPEG 667
            :|||||:..||: |||..|
Worm  1062 EVKGKGECLTYY-LEGRTG 1079

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Da	NP_001036718.1	HNOB	2..161	CDD:285002	35/173 (20%)
		HNOBA	218..476	CDD:285003	65/295 (22%)
		CYCc	457..643	CDD:214485	77/193 (40%)
		Guanylate_cyc	485..662	CDD:278633	76/184 (41%)
gcy-9	NP_509897.3	Periplasmic_Binding_Protein_Type_1	66..416	CDD:299141
		ANF_receptor	69..404	CDD:279440
		PKc_like	550..820	CDD:304357	64/343 (19%)
		HNOBA	<837..883	CDD:285003	15/45 (33%)
		CYCc	862..1054	CDD:214485	77/193 (40%)
		Guanylate_cyc	889..1076	CDD:278633	77/189 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810