DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc89Da and gcy-33

DIOPT Version :9

Sequence 1:	NP_001036718.1	Gene:	Gyc89Da / 42001	FlyBaseID:	FBgn0038435	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	NP_001256392.1	Gene:	gcy-33 / 179644	WormBaseID:	WBGene00001553	Length:	947	Species:	Caenorhabditis elegans

Alignment Length:	694	Identity:	212/694 - (30%)
Similarity:	346/694 - (49%)	Gaps:	114/694 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYGMLYESVQHYVQEEYGVDIWRKVCHIIDCKHNSFKTHQIYPDKLMPDIAEALSACTGESFDFC 65
            |||::.|.|:..:||.:|..:..:|..:......|..||..|.:.::|.:.:|:...||..::..
Worm     1 MYGLVIEGVRFMIQENWGPQVLLQVQKLTSLSEKSVSTHDQYSEHVVPQMFKAIHEITGTPYEQI 65

  Fly    66 MNFFGRCFVRFFSNFGYDKMIRSTGRYFCDFLQSIDNIHLIMRFTYPKMKSPSMQLTNMDDNGAV 130
            ....||.||:|....||..::...||.|.||::.:||||...||:|||:::||....:..::|.:
Worm    66 GVLAGRFFVQFLIRNGYGDLMNVMGRRFSDFIKGLDNIHEYFRFSYPKLRAPSFYCKSESEDGLI 130

  Fly   131 ILYRSSRTGMSKYLIGQMTEVAREFYGLEIKAYVIESQNDISGGTAGPIKLTDGPLTVIVKYRLD 195
            :.|||.|||...|:|||:.|:||.||.|:|...|::             |...|..|.:| .::.
Worm   131 LHYRSRRTGYLSYVIGQLVELARVFYQLDIGIQVLK-------------KKEKGRFTFVV-LKIS 181

  Fly   196 FDN----------------REYMAKRVNTEAHPSQLKMPTVKLDVFLDLFPFTFVLNHDMKITHA 244
            |||                .||:.  |:|::              ||.:|||....|..::|..|
Worm   182 FDNVGLGQDLKLKERVKNLNEYLP--VDTKS--------------FLQMFPFHIAFNKKLEILMA 230

  Fly   245 GEKIVETWIMHNPGANPKSFIGTHVMDLFQCRRP--KDTTIDWDTLIQMRAVLFEFELIRTGHNR 307
            |:.::.  :|.|       ..|..:.|:|..:||  |.|.   :.::..:..:|:.|.:.....:
Worm   231 GQGLLN--LMPN-------IQGLLMTDVFDLQRPCIKFTA---EGIMVHQNCVFQIESLHPVVKQ 283

  Fly   308 AAYDAVLNMDFENYDEMDLNEAQTMALAKAQEFSESHPVDDDESAREDEIDPATGERRSSQGLRS 372
            ...:..:.::....|::.|               |...|.|:|...|              .|..
Worm   284 TEENITVQINDITEDKVSL---------------EKKTVMDNEYGLE--------------SLPY 319

  Fly   373 ILLKGQMFYIKDVDSLIFLCSPLIENLDELHGIGLYLNDLNPHGLSRELVMAGWQHCSKLEIMFE 437
            :.|:|.:..:|..::.:.|.:.:::.||.:..:||||||......:||::||..|....|:.|.|
Worm   320 VTLRGPITVLKSSETFLLLATCVVDTLDTMFKMGLYLNDFGESDCNREIIMATIQKSDTLKTMLE 384

  Fly   438 KEEQRSDEL-EKSLELADSWKRQGDELLYSMIPRPIAE-RMRLSEEQVCQSFEEVSVIFLEV--- 497
            .|::||:.| |.:.|:::: |:....||..|:|..:|: .||......|::||.||:.|:.|
Worm   385 NEKRRSEVLTEMTREISEA-KKTARTLLTQMMPYEVAQTMMRSGSVDHCEAFECVSIGFIRVCDF 448

  Fly   498 --MNVYDEGLNSIQGAMQTVNTLNKVFSALDEEIISPFVYKVETVGMVYMAVSGAPDVNPLHAEH 560
              ::::.|       |.:.||.||.::|.||..:.:..||||||:|..||..:|.|..:...||.
Worm   449 SKISLFIE-------AFEVVNLLNTIYSHLDSIVDTHGVYKVETIGESYMISAGCPYRDDYDAEM 506

  Fly   561 ACDLALRVMK-----KFKAHD-MGDVAIRVGINSGPVVAGVVGQKVPRYCLFGDTVNTASRMESS 619
            ..|..|.::.     ::::|| :..|.|:.||.:||||.||||.:.|||||||||||||||||||
Worm   507 VSDCCLEMVSHIKSFEYQSHDAVKKVLIKCGIFTGPVVGGVVGVRTPRYCLFGDTVNTASRMESS 571

  Fly   620 SD-PWKIQLSKYTGDKVRQV---GYKVESRGTVQVKGKGDMETY 659
            :. |..||:.:.|.|:|.:.   .::::.:|.|.|||||||..|
Worm   572 NQTPMTIQIGQRTKDRVEKQASGAFRIKPKGNVFVKGKGDMRVY 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Da	NP_001036718.1	HNOB	2..161	CDD:285002	56/158 (35%)
		HNOBA	218..476	CDD:285003	60/261 (23%)
		CYCc	457..643	CDD:214485	78/201 (39%)
		Guanylate_cyc	485..662	CDD:278633	79/190 (42%)
gcy-33	NP_001256392.1	HNOB	2..164	CDD:377902	57/161 (35%)
		HNOBA	204..423	CDD:369471	62/276 (22%)
		CYCc	402..598	CDD:214485	78/203 (38%)
		COG5134	<595..744	CDD:227463	10/21 (48%)
		TDA11	<710..>898	CDD:293689
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4189
OMA	1	1.010	-	-		QHG46420
OrthoDB	1	1.010	-	-		D245586at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R16936
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.910