DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc89Da and acy-1

DIOPT Version :9

Sequence 1:	NP_001036718.1	Gene:	Gyc89Da / 42001	FlyBaseID:	FBgn0038435	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	NP_497970.1	Gene:	acy-1 / 175622	WormBaseID:	WBGene00000068	Length:	1253	Species:	Caenorhabditis elegans

Alignment Length:	363	Identity:	102/363 - (28%)
Similarity:	160/363 - (44%)	Gaps:	77/363 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   339 EFSESHPVDDDESAREDE--IDP------------ATGERRSSQGLRSILLKGQMFYIKDVDSLI 389
            ||:..|.|::.::.....  |.|            :|..|..||               |..|.:
Worm   919 EFNLKHLVEEQDTCNVTAIMIPPIRKGLNYTIALNSTSARTLSQ---------------DFGSPL 968

  Fly   390 FLCSPLIENLDELHGIGL--YLNDLNPHGLSRELVMAGWQHCSKLEIMFEKEEQRSDELEKSLEL 452
            |:...|   ||.:..|.|  :||               :|..:...:.|..:.|...:.|:...:
Worm   969 FIWELL---LDVILSIVLVAFLN---------------YQFETAFRMSFFGDVQARRDTERMQIV 1015

  Fly   453 ADSWKRQGDELLYSMIPRPIAERMRLSEEQVCQSFEEVSVIFLEVMNVYDEGLNSIQGAMQTVNT 517
            .|    |.|.||.::||....|.:: ::.:..::.|.|.|:|..:.|..|....:.:|..:.:..
Worm  1016 RD----QADWLLNNVIPAHAVESLK-TDTKYSENHETVGVLFASITNWNDMYEENFEGGREFLRV 1075

  Fly   518 LNKVFSALDEEIISP---FVYKVETVGMVYMAVSGAPDVNP------LH-AEH---ACDLALRVM 569
            ||:|....||.:..|   .:.|::|:|..|||.||   :||      || .||   ..|.||.|.
Worm  1076 LNEVIGDFDELLDRPDFTHIEKIKTIGPAYMAASG---LNPERKKNMLHPKEHLYQMVDFALAVQ 1137

  Fly   570 KKFKAHDMG----DVAIRVGINSGPVVAGVVGQKVPRYCLFGDTVNTASRMESSSDPWKIQLSKY 630
            ......:..    |...::|:|.|||.|||:|.....|.::|||||.||||.|:....:||:|::
Worm  1138 HVLSVFNEDLLNFDFVCKLGLNIGPVTAGVIGTTKLYYDIWGDTVNIASRMYSTGVLNRIQVSQH 1202

  Fly   631 TGDKVRQVGYKVESRGTVQVKG-KGDMETYWLLEGPEG 667
            |.:.:.. .|:.|.|..::||| .|.|:|| ||.|.:|
Worm  1203 TREYLLD-RYEFEFRDHIEVKGIDGGMDTY-LLVGRKG 1238

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Da	NP_001036718.1	HNOB	2..161	CDD:285002
		HNOBA	218..476	CDD:285003	32/152 (21%)
		CYCc	457..643	CDD:214485	64/202 (32%)
		Guanylate_cyc	485..662	CDD:278633	66/194 (34%)
acy-1	NP_497970.1	MreD	127..>223	CDD:294686
		CYCc	297..469	CDD:214485
		Guanylate_cyc	317..503	CDD:278633
		SDF	<773..982	CDD:294387	16/80 (20%)
		CYCc	1016..1215	CDD:214485	65/207 (31%)
		Guanylate_cyc	1041..1235	CDD:278633	68/198 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810