Protein Alignment Gyc89Da and gcy-12

DIOPT Version :10

• Sequence 1: NP_001036718.1
• Gene: Gyc89Da / 42001
• FlyBaseID: FBgn0038435
• Length: 667
• Species: Drosophila melanogaster
• Sequence 2: NP_494995.2
• Gene: gcy-12 / 173902
• WormBaseID: WBGene00001538
• Length: 1679
• Species: Caenorhabditis elegans
• Alignment Length: 640
• Identity: 153/640 - (23%)
• Similarity: 262/640 - (40%)
• Gaps: 180/640 - (28%)

  Fly   106 IMRFTYPKMKSPSMQLTNMDDNG--AVILYRSSRTGMSKYLIGQ-----MTEVAREFYGLEIKAY 163
            :|:|.  |.|:|......:...|  .:..|:.:..|:...:.|:     ..|..:|...:...|:
 Worm   661 VMQFA--KTKTPWWSKAPVQGTGMRGLASYKGTLVGLKDLMYGRKPKDLTREAKKELRAMRQLAH 723

  Fly   164 VIESQNDISGGTAGPIKLTDGPLTVIVKYRLDFDNREYMAK-RVNTEAHPSQLKMPTVKLDVFLD 227
              .:.|:..|     |.:....:||:         |||.:| .::.......||:..:.:..|:|
 Worm   724 --PNVNNFLG-----IIVCQYSVTVV---------REYCSKGSLHDILRNENLKLDHMYVASFVD 772

  Fly   228 LFPFTFVLNHDMKITHAGEKIVETWIMHNPGANPKSFIGTHVMDLFQCRRPKDTTIDWDTLIQMR 292
            ......|..||.::.           ||   .|.||                     .:.||..|
 Worm   773 DLVKGMVYIHDSELK-----------MH---GNLKS---------------------TNCLITSR 802

  Fly   293 AVL----FEFELIRTGHNRAAYDAVLNMDFENY-----DEMDLN-------------EAQTMALA 335
            ..|    |....:|.|   ..||:..|: :||:     :.|.:|             :|.:..:.
 Worm   803 WTLQIADFGLRELREG---IMYDSSYNI-WENFLWTAPEAMTINGSLAISNPPTPKADAYSFGII 863

  Fly   336 KAQEFSESHP---------VDDDESAREDEIDPATGERRSSQGLRSILLKGQMFYIKDVDSLIFL 391
            ..:.|:...|         |:.:.:.::|.::
 Worm   864 FHEIFTREGPYKIYVQRGDVNGEAAPKKDSVE--------------------------------- 895

  Fly   392 CSPLIENLDELHGIGLYL----NDLNPHGLSRELVMAGWQH-----------CSKLE-------- 433
            |..|:|..........|.    :||......:|::.|.|.|           .:||:
 Worm   896 CRALVEKTVRRVYSDPYFRPDTSDLEVQNYVKEVMAACWHHDPYQRPEFKTIKNKLKPLFHQIYK 960

  Fly   434 --------IMFEKEEQRSDEL--EKSLELADSWKRQGDELLYSMIPRPIAERMRLSEEQVCQSFE 488
                    :|.||.:.:.::|  |:::||.|. :|:...||..|:|..:||::...::.:.::|.
 Worm   961 QNIMDHMVLMMEKYQTQLEDLVDERTIELKDE-QRRSQHLLQRMLPSSVAEQLLAGQDVIPEAFP 1024

  Fly   489 EVSVIFLEVMNVYDEGLNSIQG---AMQTVNTLNKVFSALDEEIISPFVYKVETVGMVYMAVSGA 550
            .|::.|.:::     |..:|.|   .|:.|..|||:::..|..|....||||||:|..||.|||.
 Worm  1025 PVTIYFSDIV-----GFTTISGESTPMEVVTFLNKLYTLFDSIIRRYDVYKVETIGDAYMVVSGV 1084

  Fly   551 PDVNPL--HAEHACDLALRVMKKFKAHDM-----GDVAIRVGINSGPVVAGVVGQKVPRYCLFGD 608
            |....:  |||....:|:.::...::..:     ..:.||:|:::||.||||||:.:|||.||||
 Worm  1085 PQYKTMEYHAEQIAMMAIHILSAVRSFSIPHRSCEPLMIRIGMHTGPCVAGVVGKTMPRYTLFGD 1149

  Fly   609 TVNTASRMESSSDPWKIQLSKYTGDKVRQV--GYKVESRGTVQVKGKGDMETYWL 661
            ||||||||||:.:..:|..|..|...:..:  |:.:|.||::.:||||.|.||||
 Worm  1150 TVNTASRMESNGEALRIHCSSSTQKVLTSIDQGFLLEERGSLAIKGKGQMTTYWL 1204

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Da	NP_001036718.1	HNOB	2..161	CDD:462233	11/61 (18%)
		HNOBA	218..476	CDD:462234	56/321 (17%)
		Nucleotidyl_cyc_III	485..662	CDD:448371	74/189 (39%)
gcy-12	NP_494995.2	Periplasmic_Binding_Protein_type1	140..527	CDD:471960
		PK_GC-A_B	648..957	CDD:270944	64/385 (17%)
		CYCc	991..1183	CDD:214485	69/197 (35%)