DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc89Da and Gucy2d

DIOPT Version :9

Sequence 1:	NP_001036718.1	Gene:	Gyc89Da / 42001	FlyBaseID:	FBgn0038435	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	NP_001124165.1	Gene:	Gucy2d / 14918	MGIID:	106030	Length:	1117	Species:	Mus musculus

Alignment Length:	700	Identity:	168/700 - (24%)
Similarity:	266/700 - (38%)	Gaps:	242/700 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 FVRFFSNFGYD--KMIRSTGRYF-----CDFLQSIDNIHLIMRFTYPKMKSPSMQLTNMD----- 125
            |:.:|...|..  :::|...|..     ..|||                ::||.:..::|
Mouse   495 FLAYFIRLGLQQLRLLRGPHRILLTSQELTFLQ----------------RTPSRRRPHVDSGSES 543

  Fly   126 ----DNGA--------------------VILYRSSRTGMSKYLIG--------------QMTEVA 152
                |.|:                    |.||:.....:.|:..|              ::.|:.
Mouse   544 RSVVDGGSPRSVTQGSARSLPAFLEHTNVALYQGEWVWLKKFEAGVAPDLRPSSLSFLRKLREMR 608

  Fly   153 RE--------FYGLEIKAYVIES----------QNDISGGTAGPIKLTDGPLTVIVKYRLDFDNR 199
            .|        |.|..:.|.|:|.          ||:                    ..|||:
Mouse   609 HENVTAFLGLFVGPGVSAMVLEHCARGSLEDLLQNE--------------------NLRLDW--- 650

  Fly   200 EYMAKRVNTEAHPSQLKMPTVKLDVFLDLFPFTFVLNHD-------------------MKIT-HA 244
                               |.|..:.|||......|:|.                   :||| |.
Mouse   651 -------------------TFKASLLLDLIRGLRYLHHRRFPHGRLKSRNCVVDTRFVLKITDHG 696

  Fly   245 GEKIVETWIMHNPGANPKSFIGTHVMDLFQCRRPKDTTIDWDTLIQMRAVLFEF----------- 298
            ..:.:|:.....|...|:..:.| ..:|.  |.|...|...| :..:..:|.|.
Mouse   697 YAEFLESHCSSRPQPAPEELLWT-APELL--RGPGKATFKGD-VFSLAIILQEVLTRDPPYCSWG 757

  Fly   299 ----ELIRTGHNRAAYDAVLNMDFENYDEMDLNEAQTMALAKAQEFSESHPVDDDESAREDEIDP 359
                |:||    :.|....|.....:.|:..|...|.|.|.     .|..| ||..|.  |:|
Mouse   758 LSAEEIIR----KVASPPPLCRPLVSPDQGPLECIQLMQLC-----WEEAP-DDRPSL--DQI-- 808

  Fly   360 ATGERRSSQGLRSILLKGQMFYIKDVDSLIFLCSPLIENLDELHGIGLYLNDLNPHGLSRELVMA 424
            .|..:..:||.::.:          |||::.:.....|:|::|
Mouse   809 YTQFKSINQGKKTSV----------VDSMLRMLEKYSESLEDL---------------------- 841

  Fly   425 GWQHCSKLEIMFEKEEQRSDELEKSLELADSWKRQGDELLYSMIPRPIAERMRLSEEQVCQSFEE 489
                          .::|::|||  ||     :|:.:.||..|:|..:|..:::......:.|::
Mouse   842 --------------VQERTEELE--LE-----RRKTERLLSQMLPPSVAHALKMGTTVEPEYFDQ 885

  Fly   490 VSVIFLEVMNVYDEGLNSIQGAMQTVNTLNKVFSALDEEIISPFVYKVETVGMVYMAVSGAPDVN 554
            |::.|.:::..  ..::::...::.|..||.:::..|..:.|..||||||:|..||..||.|..|
Mouse   886 VTIYFSDIVGF--TTISALSEPIEVVGFLNDLYTLFDAVLDSHDVYKVETIGDAYMVASGLPRRN 948

  Fly   555 -PLHAEHACDLALRVMK---KFKAHDMGDVAIRV--GINSGPVVAGVVGQKVPRYCLFGDTVNTA 613
             ..||....:|||.::.   .|:.....||.|||  |::|||.||||||..:|||||||||||||
Mouse   949 GNRHAAEIANLALDILSYAGNFRMRHAPDVPIRVRAGLHSGPCVAGVVGLTMPRYCLFGDTVNTA 1013

  Fly   614 SRMESSSDPWKIQLSKYTGDKVRQV--GYKVESRGTVQVKGKGDMETYWL 661
            |||||:..|::|.:|:.|...:..:  |||::.||..::||||..|||||
Mouse  1014 SRMESTGLPYRIHVSQSTVQALLSLDEGYKIDVRGQTELKGKGLEETYWL 1063

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Da	NP_001036718.1	HNOB	2..161	CDD:285002	22/145 (15%)
		HNOBA	218..476	CDD:285003	60/292 (21%)
		CYCc	457..643	CDD:214485	73/193 (38%)
		Guanylate_cyc	485..662	CDD:278633	77/184 (42%)
Gucy2d	NP_001124165.1	PBP1_sensory_GC_DEF-like	71..445	CDD:380594
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	529..557		5/27 (19%)
		PK_GC-2D	554..818	CDD:270945	57/323 (18%)
		CYCc	855..1044	CDD:214485	71/190 (37%)
		Interaction with NCALD. /evidence=ECO:0000250\|UniProtKB:P51839	874..915		6/42 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1096..1117
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910