DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc89Da and Gucy2c

DIOPT Version :9

Sequence 1:	NP_001036718.1	Gene:	Gyc89Da / 42001	FlyBaseID:	FBgn0038435	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	NP_001120790.1	Gene:	Gucy2c / 14917	MGIID:	106903	Length:	1072	Species:	Mus musculus

Alignment Length:	803	Identity:	184/803 - (22%)
Similarity:	308/803 - (38%)	Gaps:	244/803 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 IIDCKHNSF----KTHQIYPDKL----MPDIAEALSACTGESFDFCMNFFGRCFVRFFSNFGYDK 84
            ::|...|.:    .|...|.|.:    :|......:....|.|....:.|...::.....||:
Mouse   272 LVDLFSNHYFEENTTAPEYMDNVLVLTLPSEQSTSNTSVAERFSSGRSDFSLAYLEGTLLFGH-- 334

  Fly    85 MIRSTGRYFCDFLQSIDNIHLIMRFTYPKMKSPSMQLT--------NMDDNGAV-----ILYRSS 136
            |:::       ||::.:|:      |.||.......||        .:||:|.:     :||.|.
Mouse   335 MLQT-------FLENGENV------TGPKFARAFRNLTFQGFAGPVTLDDSGDIDNIMSLLYVSL 386

  Fly   137 RTGMSKYLIGQMTEVAREFYGLEIKAYVIESQ---NDISGGTAGP-------IKLTDGPLTVIV- 190
            .|...|.|:...|...:.....|...::.::.   ||:.|  .||       ..|| |.|.|::
Mouse   387 DTRKYKVLMKYDTHKNKTIPVAENPNFIWKNHKLPNDVPG--LGPQILMIAVFTLT-GILVVLLL 448

  Fly   191 -------KYRLDFDNREYMAKRVNTEAH-PSQLKMPTVKLDVFLDLFPF-TFVLNH-DMKI---- 241
                   |||.|.      |.|....:| ||:            ::||. |...|| .:||
Mouse   449 IALLVLRKYRRDH------ALRQKKWSHIPSE------------NIFPLETNETNHISLKIDDDR 495

  Fly   242 -----------THAGEKIVETWIMHNPG------------------ANPKSFIGTHVMD--LF-- 273
                       .:..:|::...:.|:.|                  .|...|.||..:|  :|
Mouse   496 RRDTIQRVRQCKYDKKKVILKDLKHSDGNFSEKQKIDLNKLLQSDYYNLTKFYGTVKLDTRIFGV 560

  Fly   274 --QCRR-------------PKDTTIDWDTLIQMRAVLFEFELIRTGHNRAAYDAVLNMDFENYDE 323
              .|.|             |..|.:||:         |:..::.        |....|.:.:..:
Mouse   561 VEYCERGSLREVLNDTISYPDGTFMDWE---------FKISVLN--------DIAKGMSYLHSSK 608

  Fly   324 MDLN--------EAQTMALAKAQEF--SESHPVDDDESAREDEIDPATGERRSSQG--------L 370
            ::::        ...:..:.|..:|  :...|...|.....:.:..||   .|.:|        .
Mouse   609 IEVHGRLKSTNCVVDSRMVVKITDFGCNSILPPKKDLWTAPEHLRQAT---ISQKGDVYSFAIIA 670

  Fly   371 RSILLKGQMFY---IKDVDSLIFLCSP----------LIENLDELHGIGLYLNDLNPHGLSRELV 422
            :.|:|:.:.||   .:|.:..||....          .:|..||.. :.:||           ||
Mouse   671 QEIILRKETFYTLSCRDHNEKIFRVENSYGKPFRPDLFLETADEKE-LEVYL-----------LV 723

  Fly   423 MAGWQH--------------CSKLEIMF--EKEEQRSDEL---------------EKSLELADSW 456
            .:.|:.              .:|:..:|  :|.|...|.|               |:..:|..:.
Mouse   724 KSCWEEDPEKRPDFKKIESTLAKIFGLFHDQKNESYMDTLIRRLQLYSRNLEHLVEERTQLYKAE 788

  Fly   457 KRQGDELLYSMIPRPIAERMRLSEEQVCQS--FEEVSVIFLEVMNVYDEGLNSI---QGAMQTVN 516
            :.:.|.|.:.::||.:.:  .|.|:.:.:.  :|||::.|.:::     |..:|   ...|:.|:
Mouse   789 RDRADHLNFMLLPRLVVK--SLKEKGIVEPELYEEVTIYFSDIV-----GFTTICKYSTPMEVVD 846

  Fly   517 TLNKVFSALDEEIISPFVYKVETVGMVYMAVSGAPDVN-PLHAEHACDLALRVMKKFKAHDMG-- 578
            .||.::.:.|:.:....||||||:|..|:..||.|..| ..||.....:||.::......::.
Mouse   847 MLNDIYKSFDQIVDHHDVYKVETIGDAYVVASGLPMRNGNRHAVDISKMALDILSFIGTFELEHL 911

  Fly   579 ---DVAIRVGINSGPVVAGVVGQKVPRYCLFGDTVNTASRMESSSDPWKIQLSKYTGDKVRQVG- 639
               .|.||:|::|||..|||||.|:||||||||||||||||||:..|.:|.:|..|...:::..
Mouse   912 PGLPVWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHMSSSTITILKRTDC 976

  Fly   640 -YKVESRGTVQVKGKGDMETYWL 661
             :..|.||...:||:|...||||
Mouse   977 QFLYEVRGETYLKGRGTETTYWL 999

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Da	NP_001036718.1	HNOB	2..161	CDD:285002	31/153 (20%)
		HNOBA	218..476	CDD:285003	60/373 (16%)
		CYCc	457..643	CDD:214485	68/198 (34%)
		Guanylate_cyc	485..662	CDD:278633	72/190 (38%)
Gucy2c	NP_001120790.1	Periplasmic_Binding_Protein_Type_1	35..415	CDD:299141	31/157 (20%)
		PKc_like	480..749	CDD:304357	47/300 (16%)
		STYKc	502..744	CDD:214568	41/273 (15%)
		CYCc	787..978	CDD:214485	68/197 (35%)
		Guanylate_cyc	814..1001	CDD:278633	72/191 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810