DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc89Da and gc2

DIOPT Version :9

Sequence 1:	NP_001036718.1	Gene:	Gyc89Da / 42001	FlyBaseID:	FBgn0038435	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	XP_021333059.1	Gene:	gc2 / 140425	ZFINID:	ZDB-GENE-011128-8	Length:	1120	Species:	Danio rerio

Alignment Length:	814	Identity:	189/814 - (23%)
Similarity:	300/814 - (36%)	Gaps:	249/814 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYGMLYESV---QHYVQEEYGVDIWRKVCHIIDCKHNSFKTHQIYPDKLMPDIAEALSACTGESF 62
            ::|.:|.|:   .|.||.......|....:|.....|.              :.:..|:....|.
Zfish   354 LFGTIYSSIVFMAHAVQSVRAAGQWMSGGNIAQNARNL--------------LFKGGSSLQANSS 404

  Fly    63 DFCMNFFGRCFVRFFSNFGYD-----------KMIRSTGRYFCDFLQSIDNIHLIMRFTY---PK 113
            ||.|..:   .:.....|.::           .|:|..||:          ||    |.|   |:
Zfish   405 DFGMLDY---VILDTDGFSWELQPTYRIEMQTDMVRFLGRH----------IH----FPYAGPPR 452

  Fly   114 MKSPSMQLTNMDDNGAVILYRSSRTGMSKYLIGQMTEVAREFYGLEIK-AYVIESQNDISGGTAG 177
            ..|.......:...|.|.|:..    :|.:|:|.:      |..|.|. :|.|..:       ..
Zfish   453 TDSSCWFTHGIICRGGVNLFHM----ISMFLLGFL------FIFLSIGCSYCIRRK-------IN 500

  Fly   178 PIKLTDGPLTVIV---------------KYRLD----FDNREYMAKRVNTEAHPSQLK------- 216
            .|:|..||..:::               |..:|    .|.|..:::|.......||..
Zfish   501 KIRLVRGPNKILLTLNDVTFINPSLSNKKLSVDDSKASDTRMSISERSLVSPMSSQSPATYENSN 565

  Fly   217 ----------MPTVKLDVFLDLFPFT---FVLNHDMKITHAGEKIVETWIMHNPGANPKSFIG-T 267
                      |..:....|..:.|.|   |.|..|::               :...||  |:| .
Zfish   566 VAIYEGDWAWMKRLPYGTFRSITPNTSDVFELMKDLR---------------HENINP--FLGFF 613

  Fly   268 HVMDLFQ-----CRRPK--------DTTIDWDTLIQMRAVLFEFELI------------------ 301
            |...:|.     |.|..        |..:||         :|:..||
Zfish   614 HDCGVFAIVTEFCSRGSLEDLLVNDDVKLDW---------MFKSSLILDLIKGMKYLHHRNVCHG 669

  Fly   302 RTGHNRAAYDA--VLNMDFENYDEMDLNEAQTMALAKAQEFSESHPVDDDESAREDEIDPATGER 364
            |........|.  ||.:....|:|          :.::|.|....|..:|......||     .|
Zfish   670 RLKSRNCVVDGRFVLKITDYGYNE----------VLESQRFPYIEPPAEDLLWTAPEI-----LR 719

  Fly   365 RSSQGL---------------RSILLKGQMFYIKD--VDSLIF-------LCSPLIE-------- 397
            .|..||               :.::::|..|.:.:  .|.::.       :|.|::.
Zfish   720 GSYPGLHGTHSGDVYSFSIIMQEVVMRGPPFCMLENTFDEIVQKVRKPPPMCRPIVSPDHAPMEC 784

  Fly   398 ----------------NLDELHGIGLYLNDLNPHGLSRELVMAGWQHCSKLEIMFEKEEQRSDEL 446
                            ..||:......:|......:...::....|:.|.||   |...:|::||
Zfish   785 IQLMKQCWNEQPEKRPTFDEIFDQFKNVNKGKKTNIIDSMLRMLEQYSSNLE---ELIRERTEEL 846

  Fly   447 EKSLELADSWKRQGDELLYSMIPRPIAERMRLSEEQVCQSFEEVSVIFLEVMNVYDEGLNSIQGA 511
            |  :|     |::.::||..|:|..:||.::|......:.||.||:.|.:::.......||  ..
Zfish   847 E--IE-----KQKTEKLLTQMLPPSVAEALKLGTTVEPEHFESVSLYFSDIVGFTTISANS--EP 902

  Fly   512 MQTVNTLNKVFSALDEEIISPFVYKVETVGMVYMAVSGAPDVN-PLHAEHACDLALRVMK---KF 572
            ::.|:.||.:::..|..|.:..||||||:|..||..||.|..| ..||....::||.::.   .|
Zfish   903 IEVVDLLNDLYTTFDAVIGNHDVYKVETIGDAYMVASGVPVPNGNRHAAEIANMALDILSAVGTF 967

  Fly   573 KAHDMGD--VAIRVGINSGPVVAGVVGQKVPRYCLFGDTVNTASRMESSSDPWKIQLSKYTGDKV 635
            :...|.|  |.||:|:::||.||||||..:||||||||||.|||||||:..|::|.:...|...:
Zfish   968 RMRHMPDVPVRIRIGLHTGPCVAGVVGLTMPRYCLFGDTVTTASRMESTGLPYRIHVHSSTVKIL 1032

  Fly   636 RQ--VGYKVESRGTVQVKGKGDMETYWLLEGPEG 667
            .:  :||:||.|...::|||...|||| |.|.:|
Zfish  1033 MELKLGYRVELRARTELKGKRIEETYW-LTGRDG 1065

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Da	NP_001036718.1	HNOB	2..161	CDD:285002	33/175 (19%)
		HNOBA	218..476	CDD:285003	61/342 (18%)
		CYCc	457..643	CDD:214485	74/193 (38%)
		Guanylate_cyc	485..662	CDD:278633	76/184 (41%)
gc2	XP_021333059.1	PBP1_sensory_GC_DEF_like	59..440	CDD:107366	17/102 (17%)
		PK_GC-2D	551..815	CDD:270945	47/304 (15%)
		HNOBA	<824..869	CDD:311573	17/54 (31%)
		CYCc	848..1040	CDD:214485	74/198 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810