DRSC/TRiP Functional Genomics Resources

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Protein Alignment Gyc89Da and LRRK2

DIOPT Version :9

Sequence 1:NP_001036718.1 Gene:Gyc89Da / 42001 FlyBaseID:FBgn0038435 Length:667 Species:Drosophila melanogaster
Sequence 2:NP_940980.4 Gene:LRRK2 / 120892 HGNCID:18618 Length:2527 Species:Homo sapiens


Alignment Length:757 Identity:131/757 - (17%)
Similarity:248/757 - (32%) Gaps:244/757 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 YGMLYESVQHYVQEEYGVDIWRK-------------VCHIIDCKHNSFKTHQIYPDKLMPDIAEA 53
            :|.:|.:.  |..||..|.|:.|             :||:......|.....|.|..|:.::|  
Human  1890 FGSVYRAA--YEGEEVAVKIFNKHTSLRLLRQELVVLCHLHHPSLISLLAAGIRPRMLVMELA-- 1950

  Fly    54 LSACTGESFDFCMNFFGRCFVRFFSNFGYDKMIRSTGRYFCDFLQSIDNIHLI--MRF------T 110
                                    |....|::::.........||....:|:.  :|:      .
Human  1951 ------------------------SKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMII 1991

  Fly   111 YPKMKSPSMQLTNMDDNGAVILYRSSRTGMSKYL--IGQMT----------EVAR---------E 154
            |..:|..::.|..:..|.|:|. :.:..|:::|.  :|..|          ||||         :
Human  1992 YRDLKPHNVLLFTLYPNAAIIA-KIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQAD 2055

  Fly   155 FYGLEIKAYVIESQNDISGGTAGPIKLTDGPLTVIVKYRLDFDNREYMAKRVNTEAHPSQLKMPT 219
            .|...:..|.|.:    :||     ::.:|     :|:..:||..|...|.      |..:|.  
Human  2056 VYSFGLLLYDILT----TGG-----RIVEG-----LKFPNEFDELEIQGKL------PDPVKE-- 2098

  Fly   220 VKLDVFLDLFPFTFVLNHDMKITHAGEKIVETWIMHNPGANPKSFIGTHVMDLFQ-----C--RR 277
                  ....|:..|           ||:::..:..||...|.|   ..|.|:..     |  ||
Human  2099 ------YGCAPWPMV-----------EKLIKQCLKENPQERPTS---AQVFDILNSAELVCLTRR 2143

  Fly   278 ---PKDTTID--------------WDTLIQMRAVLFEFELIRTGHNRAAYDAVLNMDFENYDEMD 325
               ||:..::              |               :..||......:.|:::.|.|...:
Human  2144 ILLPKNVIVECMVATHHNSRNASIW---------------LGCGHTDRGQLSFLDLNTEGYTSEE 2193

  Fly   326 LNEAQTMALAKAQ--EFSESHPVDDDESAREDEIDPATGERRSSQGLRSILLKGQMFYIKDVDSL 388
            :.:::.:.||...  ...||..|...:|.....|:...|::|.:             ..|..||:
Human  2194 VADSRILCLALVHLPVEKESWIVSGTQSGTLLVINTEDGKKRHT-------------LEKMTDSV 2245

  Fly   389 IFLCSPLIENLDELHGIGLYLNDLNPHGLSRELVMAGWQHCSKLEIMFEKEEQRS---------- 443
              .|              ||.|..:.....:..::.|... .||.|..:|..:..          
Human  2246 --TC--------------LYCNSFSKQSKQKNFLLVGTAD-GKLAIFEDKTVKLKGAAPLKILNI 2293

  Fly   444 ----------DELEKSLELADSWKRQGDELLYSMIPRPIAERMRLSEEQVCQ-----SFEEVSVI 493
                      .|...|.|....|...|.::........|   .:|.|.:..|     :|.:.::|
Human  2294 GNVSTPLMCLSESTNSTERNVMWGGCGTKIFSFSNDFTI---QKLIETRTSQLFSYAAFSDSNII 2355

  Fly   494 FL-------------EVMNVYDEGLNSIQGAMQTVNTLNKVFSALDEEIISPFVY--KVETVGM- 542
            .:             .|:.|:|:....:.|.:..|:.|.:|....::|......|  :|:|:.: 
Human  2356 TVVVDTALYIAKQNSPVVEVWDKKTEKLCGLIDCVHFLREVMVKENKESKHKMSYSGRVKTLCLQ 2420

  Fly   543 ----VYMAVSGAP----DVNPLH----AEHACDLALRVMKKFKAHDMGDVAIRVGINSGPVVAGV 595
                :::...|..    |::...    ..:.|: ::|||...:...:.:|.:.:|.|. ....|.
Human  2421 KNTALWIGTGGGHILLLDLSTRRLIRVIYNFCN-SVRVMMTAQLGSLKNVMLVLGYNR-KNTEGT 2483

  Fly   596 VGQKVPRYCLFGDTVNTASRMESSSDPWKIQLSKYTGDKVRQ 637
            ..||..:.||....:|....:::...  .|::.|...:|:|:
Human  2484 QKQKEIQSCLTVWDINLPHEVQNLEK--HIEVRKELAEKMRR 2523

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Gyc89DaNP_001036718.1 HNOB 2..161 CDD:285002 36/200 (18%)
HNOBA 218..476 CDD:285003 48/303 (16%)
CYCc 457..643 CDD:214485 37/214 (17%)
Guanylate_cyc 485..662 CDD:278633 33/186 (18%)
LRRK2NP_940980.4 Required for RAB29-mediated activation. /evidence=ECO:0000269|PubMed:29212815 1..969
LRR 1 983..1004
leucine-rich repeat 985..1012 CDD:275380
LRR 1012..>1286 CDD:227223
LRR 2 1012..1033
leucine-rich repeat 1013..1036 CDD:275380
LRR 3 1036..1057
leucine-rich repeat 1037..1084 CDD:275380
LRR 4 1059..1080
LRR 5 1084..1105
leucine-rich repeat 1085..1108 CDD:275380
LRR 6 1108..1129
leucine-rich repeat 1109..1130 CDD:275380
LRR 7 1130..1150
leucine-rich repeat 1131..1174 CDD:275380
LRR 8 1174..1196
leucine-rich repeat 1175..1197 CDD:275380
LRR 9 1197..1218
leucine-rich repeat 1198..1221 CDD:275380
LRR 10 1221..1241
leucine-rich repeat 1222..1246 CDD:275380
LRR 11 1246..1267
leucine-rich repeat 1247..1269 CDD:275380
LRR 12 1269..1291
RocCOR 1334..1507 CDD:206741
COR 1527..1740 CDD:318343
STKc_LRRK2 1884..2135 CDD:270970 58/315 (18%)
WD 1 2139..2183 8/58 (14%)
WD 2 2188..2228 7/39 (18%)
WD 3 2233..2276 12/72 (17%)
WD 4 2281..2327 5/45 (11%)
WD 5 2333..2377 7/43 (16%)
WD 6 2402..2438 5/35 (14%)
WD 7 2443..2497 12/55 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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