DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gyc89Da and Adcy6

DIOPT Version :9

Sequence 1:	NP_001036718.1	Gene:	Gyc89Da / 42001	FlyBaseID:	FBgn0038435	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	XP_006520366.3	Gene:	Adcy6 / 11512	MGIID:	87917	Length:	1254	Species:	Mus musculus

Alignment Length:	368	Identity:	112/368 - (30%)
Similarity:	178/368 - (48%)	Gaps:	83/368 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   318 FENYDEMDLNEAQTMALAKAQEFSESHPVDDDESAREDEID-PATGERRSSQGLRSILLKGQMFY 381
            |:|||.:    .....||.:.|             ..|.:| ||.|.         :.||    |
Mouse   948 FDNYDLL----LGVHGLASSNE-------------TFDGLDCPAVGR---------VALK----Y 982

  Fly   382 IKDVDSLIFLCSPLIENLDELHGIGLYLNDLNPHGLSRELVMAGWQHCSKLEIMFEKEEQRSDEL 446
            :..|..|:|             .:.|||:.......:|...:  |    ||:...||||.  :||
Mouse   983 MTPVILLVF-------------ALALYLHAQQVESTARLDFL--W----KLQATGEKEEM--EEL 1026

  Fly   447 EKSLELADSWKRQGDELLYSMIPRPIA----ERMRLSEEQVCQSFEEVSVIFLEVMN---VYDEG 504
            :       ::.|:   ||::::|:.:|    .|.|.::|...||.|.|:|:|..:.|   .|.|
Mouse  1027 Q-------AYNRR---LLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVE- 1080

  Fly   505 LNSIQGAMQTVNTLNKVFSALDEEIISPFVY----KVETVGMVYMAVSGA-----PDVNPLHAEH 560
            |.:....::.:..||::.:..| ||||...:    |::|:|..|||.||.     ..|...|...
Mouse  1081 LEANNEGVECLRLLNEIIADFD-EIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITA 1144

  Fly   561 ACDLALRVMKKFK---AHDMGDVAIRVGINSGPVVAGVVGQKVPRYCLFGDTVNTASRMESSSDP 622
            ..|.|:|:|::.|   .|...:..:::|:|.|||||||:|.:.|:|.::|:|||.:|||:|:..|
Mouse  1145 LADYAMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVP 1209

  Fly   623 WKIQLSKYTGDKVRQVGYKVESRGTVQVKGKGDMETYWLLEGP 665
            .:||::......:...||::|.||.|:|||||:|.||:|..||
Mouse  1210 DRIQVTTDLYQVLAAKGYQLECRGVVKVKGKGEMTTYFLNGGP 1252

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Da	NP_001036718.1	HNOB	2..161	CDD:285002
		HNOBA	218..476	CDD:285003	36/162 (22%)
		CYCc	457..643	CDD:214485	66/204 (32%)
		Guanylate_cyc	485..662	CDD:278633	70/191 (37%)
Adcy6	XP_006520366.3	AC_N	83..454	CDD:318454
		Guanylate_cyc	456..640	CDD:306677
		DUF1053	668..754	CDD:368844
		Guanylate_cyc	1056..1250	CDD:306677	71/195 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810