DRSC/TRiP Functional Genomics Resources

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Protein Alignment Gyc89Da and ADCY8

DIOPT Version :9

Sequence 1:NP_001036718.1 Gene:Gyc89Da / 42001 FlyBaseID:FBgn0038435 Length:667 Species:Drosophila melanogaster
Sequence 2:NP_001106.1 Gene:ADCY8 / 114 HGNCID:239 Length:1251 Species:Homo sapiens


Alignment Length:294 Identity:87/294 - (29%)
Similarity:149/294 - (50%) Gaps:38/294 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly   406 GLYL--NDLNPHG------------LSRELVMAGWQHCSKLE----IMFEKEEQRSDELEKSLEL 452
            ||:|  ::||..|            |....::|.:.|..:||    :.|....|..:|:.:..||
Human   879 GLFLRYDNLNHSGEDFLGTKEVSLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKEL 943

  Fly   453 ADSWKRQGDELLYSMIPRPIAERMRLSEEQVCQSFEEVSVIFLEV---MNVYDEGLNSIQGAMQT 514
            .:..:.....:|.|.:.|...|:.|.:||...||::.|.|:|..:   .:.|.:...:.|| ::.
Human   944 REHNENMLRNILPSHVARHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQG-VEC 1007

  Fly   515 VNTLNKVFSALDE---EIISPFVYKVETVGMVYMAVSG-APDVNPLHAE--HACDLA------LR 567
            :..||::.:..||   |.....:.|::|:|..|||||| :|:......:  |.|.||      ..
Human  1008 LRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGHLCALADFSLALTE 1072

  Fly   568 VMKKFKAHDMGDVAIRVGINSGPVVAGVVGQKVPRYCLFGDTVNTASRMESSSDPWKIQLSKYTG 632
            .:::...|...:..:|:||:.|.|||||:|.|.|:|.::|.|||.||||:|:....:||:.:.|.
Human  1073 SIQEINKHSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETY 1137

  Fly   633 DKVRQVGYKVESRGTVQVKG----KGDMETYWLL 662
            ..::..|:..:.||.:.|||    :|.::||:||
Human  1138 LILKDQGFAFDYRGEIYVKGISEQEGKIKTYFLL 1171

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Gyc89DaNP_001036718.1 HNOB 2..161 CDD:285002
HNOBA 218..476 CDD:285003 20/87 (23%)
CYCc 457..643 CDD:214485 61/200 (31%)
Guanylate_cyc 485..662 CDD:278633 62/195 (32%)
ADCY8NP_001106.1 Involved in ORAI1, STIM1, PPP2CA and PPP2R1A interaction. /evidence=ECO:0000250|UniProtKB:P40146 1..182
Involved in AKAP5 and PRKAR2A interaction. /evidence=ECO:0000250|UniProtKB:P40146 1..109
Essential for CALM1 interaction. /evidence=ECO:0000250|UniProtKB:P40146 38..40
Essential for CALM1 interaction. /evidence=ECO:0000250|UniProtKB:P40146 49..51
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 50..92
AC_N <161..400 CDD:292831
CYCc 366..564 CDD:214485
Guanylate_cyc 405..589 CDD:278633
DUF1053 617..711 CDD:283888
CYCc 944..1148 CDD:214485 61/204 (30%)
Guanylate_cyc 973..1172 CDD:278633 64/200 (32%)
Involved in CALM1 interaction. /evidence=ECO:0000250|UniProtKB:P40146 1109..1251 23/63 (37%)
Required for both calcium stimulation and maintenance of autoinhibition. /evidence=ECO:0000250|UniProtKB:P40146 1200..1215
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1223..1251
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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