DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc89Da and ADCY6

DIOPT Version :9

Sequence 1:	NP_001036718.1	Gene:	Gyc89Da / 42001	FlyBaseID:	FBgn0038435	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	NP_001377760.1	Gene:	ADCY6 / 112	HGNCID:	237	Length:	1168	Species:	Homo sapiens

Alignment Length:	514	Identity:	137/514 - (26%)
Similarity:	223/514 - (43%)	Gaps:	137/514 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   206 VNTEAHPSQLKMPTVKLDVFLDLFPFTFVLNH----------------DMKITHAGEKIVETWIM 254
            |.:.||.:.:.:.:|.| ||.......|..||                |:...|..:      :.
Human   736 VRSRAHSTAVGIFSVLL-VFTSAIANMFTCNHTPIRSCAARMLNLTPADITACHLQQ------LN 793

  Fly   255 HNPGAN-------------PKSFIGTHVMDLFQCRRPKDTTIDWDTLIQMRAVLFEFELIRTGHN 306
            ::.|.:             |:.|||..::.|.     ..:.....:.|...|::|...||
Human   794 YSLGLDAPLCEGTMPTCSFPEYFIGNMLLSLL-----ASSVFLHISSIGKLAMIFVLGLI----- 848

  Fly   307 RAAYDAVLNMD-----FENYDEMDLNEAQTMALAKAQEFSESHPVDDDESAREDEID-PATGERR 365
               |..:|.:.     |:|||.:    .....||.:.|             ..|.:| ||.|.
Human   849 ---YLVLLLLGPPATIFDNYDLL----LGVHGLASSNE-------------TFDGLDCPAAGR-- 891

  Fly   366 SSQGLRSILLKGQMFYIKDVDSLIFLCSPLIENLDELHGIGLYLNDLNPHGLSRELVMAGWQHCS 430
                   :.||    |:..|..|:|             .:.|||:.......:|...:  |
Human   892 -------VALK----YMTPVILLVF-------------ALALYLHAQQVESTARLDFL--W---- 926

  Fly   431 KLEIMFEKEEQRSDELEKSLELADSWKRQGDELLYSMIPRPIA----ERMRLSEEQVCQSFEEVS 491
            ||:...||||.  :||:       ::.|:   ||::::|:.:|    .|.|.::|...||.|.|:
Human   927 KLQATGEKEEM--EELQ-------AYNRR---LLHNILPKDVAAHFLARERRNDELYYQSCECVA 979

  Fly   492 VIFLEVMN---VYDEGLNSIQGAMQTVNTLNKVFSALDEEIISPFVY----KVETVGMVYMAVSG 549
            |:|..:.|   .|.| |.:....::.:..||::.:..| ||||...:    |::|:|..|||.||
Human   980 VMFASIANFSEFYVE-LEANNEGVECLRLLNEIIADFD-EIISEERFRQLEKIKTIGSTYMAASG 1042

  Fly   550 A-----PDVNPLHAEHACDLALRVMKKFK---AHDMGDVAIRVGINSGPVVAGVVGQKVPRYCLF 606
            .     ..|...|.....|.|:|:|::.|   .|...:..:::|:|.|||||||:|.:.|:|.::
Human  1043 LNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIW 1107

  Fly   607 GDTVNTASRMESSSDPWKIQLSKYTGDKVRQVGYKVESRGTVQVKGKGDMETYWLLEGP 665
            |:|||.:|||:|:..|.:||::......:...||::|.||.|:|||||:|.||:|..||
Human  1108 GNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLECRGVVKVKGKGEMTTYFLNGGP 1166

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Da	NP_001036718.1	HNOB	2..161	CDD:285002
		HNOBA	218..476	CDD:285003	58/296 (20%)
		CYCc	457..643	CDD:214485	66/204 (32%)
		Guanylate_cyc	485..662	CDD:278633	70/191 (37%)
ADCY6	NP_001377760.1	AC_N	<16..368	CDD:318454
		Guanylate_cyc	370..554	CDD:306677
		DUF1053	582..668	CDD:399378
		Guanylate_cyc	970..1164	CDD:306677	71/195 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810