DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Gyc89Da and ADCY1

DIOPT Version :9

Sequence 1:NP_001036718.1 Gene:Gyc89Da / 42001 FlyBaseID:FBgn0038435 Length:667 Species:Drosophila melanogaster
Sequence 2:NP_066939.1 Gene:ADCY1 / 107 HGNCID:232 Length:1119 Species:Homo sapiens


Alignment Length:268 Identity:83/268 - (30%)
Similarity:134/268 - (50%) Gaps:43/268 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly   428 HCSKLEIMF--------EKEEQRSDELEKSLELADSWKRQGDELLYSMIPRPIAERMRLSE---- 480
            |..:::|..        :.||:|.| :||.       |.....:|::::|..:|:...:|.    
Human   801 HARQVDIRLRLDYLWAAQAEEERED-MEKV-------KLDNRRILFNLLPAHVAQHFLMSNPRNM 857

  Fly   481 EQVCQSFEEVSVIFLEVMNVYD-----EGLNSIQGAMQTVNTLNKVFSALDEEIISPF---VYKV 537
            :...||:.:|.|:|..:.|..|     :|.|.   .::.:..||::.:..||.:...|   :.|:
Human   858 DLYYQSYSQVGVMFASIPNFNDFYIELDGNNM---GVECLRLLNEIIADFDELMEKDFYKDIEKI 919

  Fly   538 ETVGMVYMAVSG-APDVN-------PLHAEHACDLALR---VMKKFKAHDMGDVAIRVGINSGPV 591
            :|:|..|||..| ||...       ..|.....|.|:.   |:.:.......|..:|||||.|||
Human   920 KTIGSTYMAAVGLAPTSGTKAKKSISSHLSTLADFAIEMFDVLDEINYQSYNDFVLRVGINVGPV 984

  Fly   592 VAGVVGQKVPRYCLFGDTVNTASRMESSSDPWKIQLSKYTGDKVRQVGYKVESRGTVQVKGKGDM 656
            ||||:|.:.|:|.::|:|||.||||:|:....:||:::.....:|:..|....||.|.|||||:|
Human   985 VAGVIGARRPQYDIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLRRCPYHFVCRGKVSVKGKGEM 1049

  Fly   657 ETYWLLEG 664
            .||: |||
Human  1050 LTYF-LEG 1056

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Gyc89DaNP_001036718.1 HNOB 2..161 CDD:285002
HNOBA 218..476 CDD:285003 12/55 (22%)
CYCc 457..643 CDD:214485 61/208 (29%)
Guanylate_cyc 485..662 CDD:278633 67/195 (34%)
ADCY1NP_066939.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..28
AC_N <161..292 CDD:292831
CYCc 258..453 CDD:214485
Guanylate_cyc 294..476 CDD:278633
Interaction with calmodulin. /evidence=ECO:0000250 493..520
CYCc 826..1037 CDD:214485 63/220 (29%)
Guanylate_cyc 859..1056 CDD:278633 68/200 (34%)
Interaction with calmodulin. /evidence=ECO:0000250 1024..1047 8/22 (36%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.