DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gyc89Da and gucy1b1

DIOPT Version :9

Sequence 1:	NP_001036718.1	Gene:	Gyc89Da / 42001	FlyBaseID:	FBgn0038435	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	XP_004911214.1	Gene:	gucy1b1 / 100379900	XenbaseID:	XB-GENE-950986	Length:	618	Species:	Xenopus tropicalis

Alignment Length:	689	Identity:	194/689 - (28%)
Similarity:	322/689 - (46%)	Gaps:	112/689 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYGMLYESVQHYVQEEYGVDIWRKVCHIIDCK-------HNSFKTHQIYPDKLMPDIAEALSACT 58
            |||.:..:::..|...||.::|.      |.|       ...|....||.|....|:..|.:...
Frog     1 MYGFVNHALELLVIRNYGPEVWE------DIKKEAQLDEEGQFLVRIIYDDSKTYDLVSAATKVL 59

  Fly    59 GESFDFCMNFFGRCFVRFFSNFGYDKMIRSTGRYFCDFLQSIDNIHLIMRFTYPKMKSPSMQLTN 123
            ..:....:..||..|..|....|||.::|..|....:|||::|.:|..:...||.|::||.:.|:
Frog    60 NLNAGDILQMFGNMFFVFCQESGYDTILRVLGSNVREFLQNLDALHDHLGTIYPGMRAPSFRCTD 124

  Fly   124 MD-DNGAVILYRSSRTGMSKYLIGQMTEVAREFYGLEIKAYVIESQNDISGGTAGPIKLTDGPLT 187
            .: ..|.::.|.|.|.|:...:||.:..||::.:|.||...||:.:|:....|...|:..|
Frog   125 AEKGKGLILHYYSEREGLQDIVIGIVKTVAQQIHGTEIDMKVIQQRNEECDHTQFLIEEKD---- 185

  Fly   188 VIVKYRLDFDNREYMAKRVNTEAHPSQLKMPTVKLDVFLDLFPFTFVLNHDMKITHAGEKIVETW 252
              .:....:::::...:....|:..|..        .|...|||..:.:.|:.:|..|..|....
Frog   186 --TREEDFYEDQDRFEENGTQESRISPY--------TFCKAFPFHIMFDRDLFVTQCGNAIYRVL 240

  Fly   253 IMHNPGANPKSFIGTHVMDLFQCRRPKDTTIDWDTLIQMRAVLFEFELIRTGHNRAAYDAVLNMD 317
            ....||       ..:::.:|...||.                                  :::.
Frog   241 PQLQPG-------NCNLLSVFSLVRPH----------------------------------IDIS 264

  Fly   318 FENYDEMDLNEAQTMALAKAQEFSESHPVDDDESAREDEIDPATGERRSSQGLRSILLKGQMFYI 382
            |...    |:...|:.:.:::|    ..:|.::|..|||:   ||..     :..:.|||||.|:
Frog   265 FHGI----LSHINTVFVLRSKE----GLLDVEKSESEDEL---TGTE-----ISCLRLKGQMIYL 313

  Fly   383 KDVDSLIFLCSPLIENLDELHGIGLYLNDLNPHGLSRELVMAGWQH------CSKLEIMFEKEEQ 441
            .:.|:::|||||.:.|||:|...||||:|:..|..:|:||:.|.|.      ..:|||:
Frog   314 PEADNILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFREEYKLTQELEIL------ 372

  Fly   442 RSDELEKSLELADSWKRQGDELLYSMIPRPIAERMRLSEEQVCQSFEEVSVIFLEVM--NVYDEG 504
             :|.|:.:|...:..|::.|.||||::|..:|..:|.......:.::.|:::|..::  |.:...
Frog   373 -TDRLQHTLRALEDEKKKTDTLLYSVLPPSVANELRHKRPVPAKRYDNVTILFSGIVGFNTFCSK 436

  Fly   505 LNSIQGAMQTVNTLNKVFSALD---EEIISPFVYKVETVGMVYMAVSGAPDVNPLHAEHACDLAL 566
            ..|.:|||:.||.||.:::..|   :...:|:||||||||..||.|||.|:....||...|.|||
Frog   437 HASGEGAMKIVNLLNDIYTRFDILTDSRNNPYVYKVETVGDKYMTVSGIPEPCVHHARSICHLAL 501

  Fly   567 RVMK---KFKAHDMGDVAIRVGINSGPVVAGVVGQKVPRYCLFGDTVNTASRMESSSDPWKIQLS 628
            .:|:   :.:. |...|.|.:||::|.||.||:||::|||||||:|||..||.|::.:..||.:|
Frog   502 DMMEIAGQVQV-DGESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVS 565

  Fly   629 KYT-----GDKVRQVGYKVESRGTVQVKGKGDMETYWLL 662
            :||     ..:.....:.::.||.|.:|||.|....|.|
Frog   566 EYTYRCLMSPENSDPQFHLQYRGPVSMKGKTDPMQVWFL 604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Da	NP_001036718.1	HNOB	2..161	CDD:285002	45/166 (27%)
		HNOBA	218..476	CDD:285003	65/263 (25%)
		CYCc	457..643	CDD:214485	73/198 (37%)
		Guanylate_cyc	485..662	CDD:278633	72/189 (38%)
gucy1b1	XP_004911214.1	HNOB	2..166	CDD:377902	46/169 (27%)
		HNOBA	207..406	CDD:369471	66/270 (24%)
		Guanylate_cyc	412..605	CDD:306677	73/194 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245586at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920