Protein Alignment Gyc89Da and gucy1a2

DIOPT Version :10

• Sequence 1: NP_001036718.1
• Gene: Gyc89Da / 42001
• FlyBaseID: FBgn0038435
• Length: 667
• Species: Drosophila melanogaster
• Sequence 2: NP_001120379.1
• Gene: gucy1a2 / 100145454
• XenbaseID: XB-GENE-1011801
• Length: 712
• Species: Xenopus tropicalis
• Alignment Length: 653
• Identity: 160/653 - (24%)
• Similarity: 282/653 - (43%)
• Gaps: 155/653 - (23%)

  Fly    27 HIIDCK------HNSFKTHQIYPDKLMPDIAEALSA---CT----GESFD-----FCMNFFGRCF 73
            |:|.|:      ||: .....|.:....:.||.:|.   ||    |..|:     |...||..||
 Frog    97 HVIGCRDAERNLHNA-SVRCAYAENSGKEDAEDISGILQCTANMLGIKFEELQERFGEEFFSICF 160

  Fly    74 VRFFSNFGYDKMIRSTGRYFCDFLQSIDNIHLIMRFTYPK---MKSPSMQLTNMDDNGAVIL--- 132
            ..      .::::|:.|....||....|.:...:|.:..:   ::|||.....:.| |.::|
 Frog   161 EE------NERVLRAVGGTLHDFFNGFDALLEHIRTSIGRQVTLESPSFLCKELAD-GTLLLSCF 218

  Fly   133 YRSSRTGMSKYLIGQMTEVAREFYGLEIKAYVIESQNDISGGTAGPIKLTDGPLTVIVKYRLDFD 197
            :.....|.:  :.|.:....::.|.|:::   :|..|:::.... |..:..|....:.....:.|
 Frog   219 HLHHIVGFA--MKGLIKAAGKKIYQLKVE---VEQVNNVNEKPC-PDIIRPGNFNCLTFKIKECD 277

  Fly   198 NREYMAKRVNTEAH-PSQLKMPTVKLDVFLDLFPFTFVLNHDMKITHAGE--------KIVETWI 253
            |...|...:...:| ||.|:   :.:..|...|||..:.:.:|.|...||        ::.:|..
 Frog   278 NANLMKAPLLQSSHIPSDLR---ISISTFCRAFPFHLMFDPNMLILQLGEGLRKLIKCEVHKTMQ 339

  Fly   254 MHNPGANPKSFIGTHVMDLFQCRRPKDTTIDWDTLIQMRAVLFEFELIRTG-----HNRAAYDAV 313
            .|               |.|:...||            .:..||..|:|..     .|:.  ||
 Frog   340 FH---------------DSFEIVSPK------------ISCTFEQVLLRLSTPFVIRNKP--DA- 374

  Fly   314 LNMDFENYDEMDLNEAQTMALAKAQEFSESHPVDDDESAREDEIDPATGERRSSQGLRSILLKGQ 378
              ..|||.|             |..|                                   :|||
 Frog   375 --PTFENKD-------------KVME-----------------------------------VKGQ 389

  Fly   379 MFYIKDVDSLIFLCSPLIENLDELHGIGLYLNDLNPHGLSRELVMAGWQHCSKLEIMFEKEEQRS 443
            |.|:.:..|::||.||.::.||||.|.||:|:|:..|..:|::::.|.|  :|.:...:|   |.
 Frog   390 MIYVPESSSILFLGSPRVDKLDELMGRGLHLSDIPIHDATRDVILVGEQ--AKAQDGLKK---RM 449

  Fly   444 DE----LEKSLELADSWKRQGDELLYSMIPRPIAERMRLSEEQVCQSFEEVSVIFLEVMNVYDEG 504
            |:    |||:.:..:..|::..:||||:.|..:|:::...:....:.|::|:::|.:::     |
 Frog   450 DKLKATLEKTHQALEEEKKKTVDLLYSIFPGDVAQQLWEGKSVQARKFDDVTMLFSDIV-----G 509

  Fly   505 LNSIQG---AMQTVNTLNKVFSALDEEIISPFVYKVETVGMVYMAVSGAPDVNPLHAEHACDLAL 566
            ..::..   .||.::.||::::..|.:.....:|||||:|..|...:|....:..||:....:||
 Frog   510 FTAVCAQCTPMQVISMLNELYTRFDYQCGFLDIYKVETIGDAYCVAAGLLRQSNSHAKPIALMAL 574

  Fly   567 RVM---KKFKAHDMGDVAIRVGINSGPVVAGVVGQKVPRYCLFGDTVNTASRMESSSDPWKIQLS 628
            ::|   ::....|...:.:|:||:||.|:|||||.::|||||||:.|..||:.||.|.|.:|.:|
 Frog   575 KMMELSEEVLTPDGRPIKMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVS 639

  Fly   629 KYT 631
            ..|
 Frog   640 PTT 642

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gyc89Da	NP_001036718.1	HNOB	2..161	CDD:462233	34/157 (22%)
		HNOBA	218..476	CDD:462234	64/274 (23%)
		Nucleotidyl_cyc_III	485..662	CDD:448371	51/153 (33%)
gucy1a2	NP_001120379.1	Pap_E4	30..>86	CDD:367150
		HNOB	<137..248	CDD:462233	23/122 (19%)
		HNOBA	296..486	CDD:462234	65/277 (23%)
		Guanylate_cyc	492..679	CDD:425528	51/156 (33%)