DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CSN5 and RRI1

DIOPT Version :9

Sequence 1:	NP_477442.1	Gene:	CSN5 / 42000	FlyBaseID:	FBgn0027053	Length:	327	Species:	Drosophila melanogaster
Sequence 2:	NP_010065.2	Gene:	RRI1 / 851310	SGDID:	S000002375	Length:	440	Species:	Saccharomyces cerevisiae

Alignment Length:	283	Identity:	93/283 - (32%)
Similarity:	139/283 - (49%)	Gaps:	72/283 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 FKDIKISALALLKMVMHARSGGTLEVMGLMLGKVEDNTMIVMDAFALPVEGTETRVNAQAQAYEY 113
            :..:.||.|:..|:..:|..||.:|:||:::|....:.::|||.|.|||.|||||||||.::|||
Yeast    68 YTHVLISKLSCEKITHYAVRGGNIEIMGILMGFTLKDNIVVMDCFNLPVVGTETRVNAQLESYEY 132

  Fly   114 MTAYM----------EAAKEVGRMEHAVGWYHSHPGYGCWLSGIDVSTQMLNQTYQEPFVAIVVD 168
            |..|:          :.....|...:.|||:||||||.||||.||:.||.|||.:|:|:||||||
Yeast   133 MVQYIDEMYNHNDGGDGRDYKGAKLNVVGWFHSHPGYDCWLSNIDIQTQDLNQRFQDPYVAIVVD 197

  Fly   169 PVRTVSAGKVCLGAFRTYPKGYKPPNEEPSEYQTIPLNKIEDFGVHCKQYYPLEISYFKSALDR- 232
            |::::....:.:|||||..                  :|.:|..  ...||.||...|.|.|:|
Yeast   198 PLKSLEDKILRMGAFRTIE------------------SKSDDNS--ATSYYELETIIFDSELNRA 242

  Fly   233 -----------------------RLLDSLWNKYWVNTLGSSGLLTNTEYTTGQIMDLSEKLEQSE 274
                                   ||:||:  |.:...:.|..:.|..:..|     .||:: .:|
Yeast   243 LFETKLNLHCVIEDDESEQISLNRLIDSM--KQYSYLMDSKNVRTRIKLAT-----TSERV-SNE 299

  Fly   275 NFLGRGTDVNEKRSEDKLSKATR 297
            |          |::.|..:::||
Yeast   300 N----------KKNIDYQNRSTR 312

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CSN5	NP_477442.1	MPN_RPN11_CSN5	41..305	CDD:163700	93/283 (33%)
RRI1	NP_010065.2	MPN_RPN11_CSN5	62..346	CDD:163700	93/283 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342234
Domainoid	1	1.000	112	1.000	Domainoid score	I1360
eggNOG	1	0.900	-	-		E1_COG1310
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002867
OrthoInspector	1	1.000	-	-		oto99867
orthoMCL	1	0.900	-	-		OOG6_102889
Panther	1	1.100	-	-	LDO	PTHR10410
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R256
SonicParanoid	1	1.000	-	-		X2224
TreeFam	1	0.960	-	-
	11	10.730