Protein Alignment CSN5 and BRCC3

DIOPT Version :10

• Sequence 1: NP_477442.1
• Gene: CSN5 / 42000
• FlyBaseID: FBgn0027053
• Length: 327
• Species: Drosophila melanogaster
• Sequence 2: XP_005274808.1
• Gene: BRCC3 / 79184
• HGNCID: 24185
• Length: 317
• Species: Homo sapiens
• Alignment Length: 331
• Identity: 73/331 - (22%)
• Similarity: 121/331 - (36%)
• Gaps: 95/331 - (28%)

  Fly    30 AEQQRQIIDAKPWEKDPHFFKDIKISALALLKMVMHARSGGTLEVMGLMLGKVEDNTMIVMDAFA 94
            |.|..|.:.|...|.|            |.|..:.||.|....|||||.:|::.|:|......||
Human     2 AVQVVQAVQAVHLESD------------AFLVCLNHALSTEKEEVMGLCIGELNDDTSRSDSKFA 54

  Fly    95 LPVEGTETRVNA---------------------------QAQAYEYMTAYMEA---AKEVGRMEH 129
              ..|||.|..|                           :....:...|..||   |:..||...
Human    55 --YTGTEMRTVAEKVDAVRIVHIHSVIILRRSDKRKDRVEISPEQLSAASTEAERLAELTGRPMR 117

  Fly   130 AVGWYHSHPGYGCWLSGIDVSTQMLNQTYQEPFVAIVVD---PVRTVSAGKVCLGAFRTY----- 186
            .||||||||....|.|.:||.||.:.|...:.||.::..   ..:....|:|....|::.
Human   118 VVGWYHSHPHITVWPSHVDVRTQAMYQMMDQGFVGLIFSCFIEDKNTKTGRVLYTCFQSIQAQKS 182

  Fly   187 ------PKGYKPPNE--------EPSEYQTIPLNKIEDFGVHCKQYYPLEISYFKSALD------ 231
                  |:.:...::        |...|:.|      :..:|...:..:.....:||::
Human   183 SESLHGPRDFWSSSQHISIEGQKEEERYERI------EIPIHIVPHVTIGKVCLESAVELPKILC 241

  Fly   232 -------RRL-----LDSLWNKYWVNTLGSSGLLTNTEYTTGQIMD-LSEKLEQSENFLGRGTDV 283
                   ||:     |||: .|....::.:..|.:.....:|.::. |.::|||::..|   .::
Human   242 QEEQDAYRRIHSLTHLDSV-TKIHNGSVFTKNLCSQMSAVSGPLLQWLEDRLEQNQQHL---QEL 302

  Fly   284 NEKRSE 289
            .:::.|
Human   303 QQEKEE 308

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CSN5	NP_477442.1	MPN_RPN11_CSN5	41..305	CDD:163700	69/320 (22%)
BRCC3	XP_005274808.1	MPN_BRCC36	13..293	CDD:163699	64/300 (21%)