DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CSN5 and Mpnd

DIOPT Version :9

Sequence 1:	NP_477442.1	Gene:	CSN5 / 42000	FlyBaseID:	FBgn0027053	Length:	327	Species:	Drosophila melanogaster
Sequence 2:	XP_038940132.1	Gene:	Mpnd / 681944	RGDID:	1589335	Length:	488	Species:	Rattus norvegicus

Alignment Length:	218	Identity:	49/218 - (22%)
Similarity:	86/218 - (39%)	Gaps:	52/218 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 DIKISALALLKMVMH---ARSGGTLEVMGLMLGKVEDNTMIVMDAFALPVEG----TETRVNAQA 108
            ::.:|:..|..:..|   .||    ||:|.:.|:.:.|..::....|.|...    .:|....:.
  Rat   257 NVAVSSNVLFLLDFHCHLTRS----EVVGYLGGRWDINNQMLTVLRAFPCRSRLGDPDTAATVEE 317

  Fly   109 QAYEYMTAYMEAAKEVGRMEHAVGWYHSHPGYGCWLSGIDVSTQMLNQTYQ----------EPFV 163
            :.::.:..         |....||||||||......|..|:..||   .||          :|.:
  Rat   318 EIHQVLFL---------RGLSLVGWYHSHPHSPAAPSLQDIDAQM---EYQLRLQGSNNGFQPCL 370

  Fly   164 AIVVDPVRTVSAG---KVCLGAFRTYPKGYKPPNEE--PSEYQTIPLN----KIEDFGV--HCKQ 217
            |::..|..:.:.|   |:|       |....||.|:  ||:| .||::    .::|..:  ...|
  Rat   371 ALLCSPYYSGNPGPESKIC-------PFWVMPPPEQQRPSDY-GIPMDVEMAYVQDSFLTNDVLQ 427

  Fly   218 YYPLEISYFKSALDRRLLDSLWN 240
            ...:.:.::|.|.|.......|:
  Rat   428 EMMMLVEFYKGAPDLVKFQEAWS 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CSN5	NP_477442.1	MPN_RPN11_CSN5	41..305	CDD:163700	49/218 (22%)
Mpnd	XP_038940132.1	RAMA	57..157	CDD:408526
Mpnd	XP_038940132.1	MPN_2A_DUB	252..437	CDD:163698	45/203 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1310
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810