DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CSN5 and mysm1

DIOPT Version :9

Sequence 1:	NP_477442.1	Gene:	CSN5 / 42000	FlyBaseID:	FBgn0027053	Length:	327	Species:	Drosophila melanogaster
Sequence 2:	XP_021324132.1	Gene:	mysm1 / 561225	ZFINID:	ZDB-GENE-041014-28	Length:	828	Species:	Danio rerio

Alignment Length:	323	Identity:	76/323 - (23%)
Similarity:	127/323 - (39%)	Gaps:	81/323 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 QIIDAKPWEKDPHFFKDIKISALALLKMVMHAR-SGGTLEVMGLMLGKVEDNTMIVMDAFALPVE 98
            |:|..|.:.::......:.:.|.||:.|.:||. |.|  ||:||:.|..|:...::....|.|..
Zfish   506 QLIPCKTFGEERQEPYSVIVCAEALIVMDIHAHVSMG--EVIGLLGGTYEEEDKVLKICSAEPCN 568

  Fly    99 GTETRVN------AQAQAYEYMTAYMEAAKEVGRMEHAVGWYHSHPGYGCWLSGIDVSTQMLNQT 157
            ...|.:.      :|.||.|.:     ..|.:.    .||||||||.:....|..|:.||...|:
Zfish   569 SLSTGLQCEMDPVSQTQASEVL-----GVKGLS----VVGWYHSHPAFDPNPSLRDIDTQAKYQS 624

  Fly   158 Y----QEPFVAIVVDPVRTVSAG----KVCL------GAFRTYPKG-YKPP-------NEEPSEY 200
            |    ..||:.::|.|....::.    ..||      |     |.| :|.|       :.||.::
Zfish   625 YFSRGGAPFIGMIVSPYNPSNSSPQSQSTCLLVQEEPG-----PSGSHKFPYQFNMQCSAEPPDW 684

  Fly   201 Q------------------TIPLNKI--EDFGVHCKQYYPLEISYFKSALDRR----------LL 235
            .                  ::|::::  .|..:.|.:...|.|   ::.|:|.          .|
Zfish   685 SEVMRRAEWVVFKYRLCHGSVPMDRLFRRDSSLTCLEKMLLSI---RTVLERLSEVDIETFLVQL 746

  Fly   236 DSLWNKYWVNTLGSSGLLTNTEYTTGQIMDL--SEKLEQS-ENFLGRGTDVNEKRSEDKLSKA 295
            :||:|.::::..|||........|..|::..  ||.:..| ......|.|.......|||.::
Zfish   747 ESLFNTHFLSETGSSSTHLYETATQPQLLSFLSSEPISSSATEETSDGHDEPNTTGPDKLEQS 809

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CSN5	NP_477442.1	MPN_RPN11_CSN5	41..305	CDD:163700	73/317 (23%)
mysm1	XP_021324132.1	SANT	107..150	CDD:238096
		SWIRM	331..408	CDD:309539
		MPN_2A_DUB	517..699	CDD:163698	49/197 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1310
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810