DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CSN5 and cops5

DIOPT Version :9

Sequence 1:	NP_477442.1	Gene:	CSN5 / 42000	FlyBaseID:	FBgn0027053	Length:	327	Species:	Drosophila melanogaster
Sequence 2:	NP_957019.1	Gene:	cops5 / 393698	ZFINID:	ZDB-GENE-040426-1686	Length:	334	Species:	Danio rerio

Alignment Length:	326	Identity:	243/326 - (74%)
Similarity:	286/326 - (87%)	Gaps:	5/326 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SDAAQKTWELENNIQTLPSCDEIFRYDAEQQRQIIDAKPWEKDPHFFKDIKISALALLKMVMHAR 67
            |..|.|||||.|::|.:.|.|||::||.:||::|:.||||.||.|:||..|:|||||||||||||
Zfish     4 SSIAMKTWELSNSMQEVQSIDEIYKYDKKQQQEILAAKPWTKDHHYFKYCKLSALALLKMVMHAR 68

  Fly    68 SGGTLEVMGLMLGKVEDNTMIVMDAFALPVEGTETRVNAQAQAYEYMTAYMEAAKEVGRMEHAVG 132
            |||.|||||||||||:..|||:||:||||||||||||||||.|||||.||:|.||:|||:|:|:|
Zfish    69 SGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAAYEYMAAYIENAKQVGRLENAIG 133

  Fly   133 WYHSHPGYGCWLSGIDVSTQMLNQTYQEPFVAIVVDPVRTVSAGKVCLGAFRTYPKGYKPPNEEP 197
            ||||||||||||||||||||||||.:||||||:|:||.||:|||||.||||||||||||||:|.|
Zfish   134 WYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVIDPTRTISAGKVNLGAFRTYPKGYKPPDEGP 198

  Fly   198 SEYQTIPLNKIEDFGVHCKQYYPLEISYFKSALDRRLLDSLWNKYWVNTLGSSGLLTNTEYTTGQ 262
            ||||||||||||||||||||||.||:|||||:|||:||:.||||||||||.||.||||.:|||||
Zfish   199 SEYQTIPLNKIEDFGVHCKQYYALEVSYFKSSLDRKLLELLWNKYWVNTLSSSSLLTNADYTTGQ 263

  Fly   263 IMDLSEKLEQSENFLGRGT-----DVNEKRSEDKLSKATRDCSRSTIELIHGLMAQIVKDKLFNK 322
            :.||||||||:|..||||:     |.::::|||||:|||||..::|||.|||||:|::||||||:
Zfish   264 VFDLSEKLEQAEAQLGRGSFMLGLDTHDRKSEDKLAKATRDSCKTTIEAIHGLMSQVIKDKLFNQ 328

  Fly   323 V 323
            |
Zfish   329 V 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CSN5	NP_477442.1	MPN_RPN11_CSN5	41..305	CDD:163700	208/268 (78%)
cops5	NP_957019.1	MPN_RPN11_CSN5	42..312	CDD:163700	209/269 (78%)
cops5	NP_957019.1	JAMM motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01182	136..149		12/12 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576774
Domainoid	1	1.000	194	1.000	Domainoid score	I3126
eggNOG	1	0.900	-	-		E1_COG1310
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55992
Inparanoid	1	1.050	514	1.000	Inparanoid score	I1267
OMA	1	1.010	-	-		QHG54454
OrthoDB	1	1.010	-	-		D1031881at2759
OrthoFinder	1	1.000	-	-		FOG0002867
OrthoInspector	1	1.000	-	-		oto39106
orthoMCL	1	0.900	-	-		OOG6_102889
Panther	1	1.100	-	-	LDO	PTHR10410
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R256
SonicParanoid	1	1.000	-	-		X2224
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800