DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CSN5 and Cops5

DIOPT Version :9

Sequence 1:	NP_477442.1	Gene:	CSN5 / 42000	FlyBaseID:	FBgn0027053	Length:	327	Species:	Drosophila melanogaster
Sequence 2:	NP_001020866.1	Gene:	Cops5 / 312916	RGDID:	1310301	Length:	334	Species:	Rattus norvegicus

Alignment Length:	328	Identity:	245/328 - (74%)
Similarity:	287/328 - (87%)	Gaps:	5/328 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SDAAQKTWELENNIQTLPSCDEIFRYDAEQQRQIIDAKPWEKDPHFFKDIKISALALLKMVMHAR 67
            |..|||||||.||:|...|.|||::||.:||::|:.||||.||.|:||..|||||||||||||||
  Rat     6 SGMAQKTWELANNMQEAQSIDEIYKYDKKQQQEILAAKPWTKDHHYFKYCKISALALLKMVMHAR 70

  Fly    68 SGGTLEVMGLMLGKVEDNTMIVMDAFALPVEGTETRVNAQAQAYEYMTAYMEAAKEVGRMEHAVG 132
            |||.|||||||||||:..|||:||:||||||||||||||||.|||||.||:|.||:|||:|:|:|
  Rat    71 SGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAAYEYMAAYIENAKQVGRLENAIG 135

  Fly   133 WYHSHPGYGCWLSGIDVSTQMLNQTYQEPFVAIVVDPVRTVSAGKVCLGAFRTYPKGYKPPNEEP 197
            ||||||||||||||||||||||||.:||||||:|:||.||:|||||.||||||||||||||:|.|
  Rat   136 WYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVIDPTRTISAGKVNLGAFRTYPKGYKPPDEGP 200

  Fly   198 SEYQTIPLNKIEDFGVHCKQYYPLEISYFKSALDRRLLDSLWNKYWVNTLGSSGLLTNTEYTTGQ 262
            ||||||||||||||||||||||.||:|||||:|||:||:.||||||||||.||.||||.:|||||
  Rat   201 SEYQTIPLNKIEDFGVHCKQYYALEVSYFKSSLDRKLLELLWNKYWVNTLSSSSLLTNADYTTGQ 265

  Fly   263 IMDLSEKLEQSENFLGRGT-----DVNEKRSEDKLSKATRDCSRSTIELIHGLMAQIVKDKLFNK 322
            :.||||||||||..||||:     :.::::|||||:|||||..::|||.|||||:|::||||||:
  Rat   266 VFDLSEKLEQSEAQLGRGSFMLGLETHDRKSEDKLAKATRDSCKTTIEAIHGLMSQVIKDKLFNQ 330

  Fly   323 VGL 325
            :.:
  Rat   331 INV 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CSN5	NP_477442.1	MPN_RPN11_CSN5	41..305	CDD:163700	209/268 (78%)
Cops5	NP_001020866.1	MPN_RPN11_CSN5	44..314	CDD:163700	210/269 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337620
Domainoid	1	1.000	195	1.000	Domainoid score	I3069
eggNOG	1	0.900	-	-		E1_COG1310
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55992
Inparanoid	1	1.050	516	1.000	Inparanoid score	I1241
OMA	1	1.010	-	-		QHG54454
OrthoDB	1	1.010	-	-		D1031881at2759
OrthoFinder	1	1.000	-	-		FOG0002867
OrthoInspector	1	1.000	-	-		oto97660
orthoMCL	1	0.900	-	-		OOG6_102889
Panther	1	1.100	-	-	LDO	PTHR10410
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2224
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770