DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10405 and PRSS56

DIOPT Version :9

Sequence 1:	NP_001036717.1	Gene:	CG10405 / 41996	FlyBaseID:	FBgn0038431	Length:	268	Species:	Drosophila melanogaster
Sequence 2:	NP_001356777.1	Gene:	PRSS56 / 646960	HGNCID:	39433	Length:	604	Species:	Homo sapiens

Alignment Length:	256	Identity:	79/256 - (30%)
Similarity:	118/256 - (46%)	Gaps:	30/256 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 RTEAAVPRQPDSRIVNGREATEGQFPYQLSLRRQTVHICGASILSSNWAITAAHCIDGHEQQPRE 88
            |...|...:...|||.|..|..|.:|:.:.|:.....:||..:::::|.:|||||..|   .|.|
Human    92 RPSTANVTRAHGRIVGGSAAPPGAWPWLVRLQLGGQPLCGGVLVAASWVLTAAHCFVG---APNE 153

  Fly    89 F----TLRQGSIMRTSGGTVQPVKAIYKHPAYDRADMNFDVALLRTADGALSLPL---GKVAPIR 146
            .    ||.:||  |.......||..|..||.:|....:.|:||::     |..|:   |...|:.
Human   154 LLWTVTLAEGS--RGEQAEEVPVNRILPHPKFDPRTFHNDLALVQ-----LWTPVSPGGSARPVC 211

  Fly   147 LPTVGEAISESMPAVVSGWGHMSTSNPVLSSVLKSTTVLTVNQEKCHNDLRHHGGVTEAMFCAA- 210
            ||...:.........::|||.:....|...:| :...|..::.:.|...| ..|.....|.||.
Human   212 LPQEPQEPPAGTACAIAGWGALFEDGPEAEAV-REARVPLLSTDTCRRAL-GPGLRPSTMLCAGY 274

  Fly   211 -ARNTDACQGDSGGPISA-------QGTLIGIVSWGVGCADPYYPGVYTRLAHPTIRRWIR 263
             |...|:||||||||::.       :..|.|:.|||.||.:|..||||||:|  ..:.|::
Human   275 LAGGVDSCQGDSGGPLTCSEPGPRPREVLFGVTSWGDGCGEPGKPGVYTRVA--VFKDWLQ 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10405	NP_001036717.1	Tryp_SPc	36..262	CDD:214473	76/241 (32%)
CG10405	NP_001036717.1	Tryp_SPc	37..263	CDD:238113	76/241 (32%)
PRSS56	NP_001356777.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	64..96		1/3 (33%)
		Tryp_SPc	105..335	CDD:238113	76/243 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	443..475
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	574..604
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100031
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810