DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10405 and PRSS36

DIOPT Version :9

Sequence 1:	NP_001036717.1	Gene:	CG10405 / 41996	FlyBaseID:	FBgn0038431	Length:	268	Species:	Drosophila melanogaster
Sequence 2:	NP_775773.2	Gene:	PRSS36 / 146547	HGNCID:	26906	Length:	855	Species:	Homo sapiens

Alignment Length:	287	Identity:	83/287 - (28%)
Similarity:	127/287 - (44%)	Gaps:	38/287 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LLIAGILVILE----ASRTEAAVPRQ------------PDSRIVNGREATEGQFPYQLSLRRQTV 59
            ||:..:::::.    |.:..|..|.|            |.:|||.|..|..|.:|:|:||.....
Human     5 LLLPLVMLVISPIPGAFQDSALSPTQEEPEDLDCGRPEPSARIVGGSNAQPGTWPWQVSLHHGGG 69

  Fly    60 HICGASILSSNWAITAAHCI--DGHEQQPREFTLRQGSIMR---TSGGTVQPVKAIYKHPAYDRA 119
            ||||.|:::.:|.::||||.  :|..:...|:::..|...:   ..|...:.|.||.....|.:.
Human    70 HICGGSLIAPSWVLSAAHCFMTNGTLEPAAEWSVLLGVHSQDGPLDGAHTRAVAAIVVPANYSQV 134

  Fly   120 DMNFDVALLRTADGALSLPLGKVAPIRLPTVGEAISESMPAVVSGWGHMSTSNPV-LSSVLKSTT 183
            ::..|:||||.|..|...|  .|.|:.||..............:|||.:..::|: |..||:...
Human   135 ELGADLALLRLASPASLGP--AVWPVCLPRASHRFVHGTACWATGWGDVQEADPLPLPWVLQEVE 197

  Fly   184 VLTVNQEKCHNDLRHHG------GVTEAMFCAA--ARNTDACQGDSGGPI----SAQGTLIGIVS 236
            :..:.:..|.......|      .:...|.||.  ....|.||||||||:    ..:....||.|
Human   198 LRLLGEATCQCLYSQPGPFNLTLQILPGMLCAGYPEGRRDTCQGDSGGPLVCEEGGRWFQAGITS 262

  Fly   237 WGVGCADPYYPGVYTRLAHPTIRRWIR 263
            :|.||.....|||:|.:|  |...|||
Human   263 FGFGCGRRNRPGVFTAVA--TYEAWIR 287

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10405	NP_001036717.1	Tryp_SPc	36..262	CDD:214473	73/243 (30%)
CG10405	NP_001036717.1	Tryp_SPc	37..263	CDD:238113	73/243 (30%)
PRSS36	NP_775773.2	Tryp_SPc	46..286	CDD:214473	73/243 (30%)
		Tryp_SPc	47..289	CDD:238113	75/245 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	292..316
		Tryp_SPc	330..538	CDD:304450
		Tryp_SPc	601..783	CDD:304450
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149401
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100031
Panther	1	1.100	-	-	O	PTHR24276
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.930