DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pak3 and MKK2

DIOPT Version :9

Sequence 1:	NP_001262638.1	Gene:	Pak3 / 41995	FlyBaseID:	FBgn0044826	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_015185.1	Gene:	MKK2 / 855963	SGDID:	S000006061	Length:	506	Species:	Saccharomyces cerevisiae

Alignment Length:	531	Identity:	130/531 - (24%)
Similarity:	209/531 - (39%)	Gaps:	111/531 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 HEESKEIENYVNYKNKHKSQDPEKSDDDGSSTATETESSSGCGSSAGNSNSSSINDSSQQSTVPL 161
            |:::.::...||....      .||.:||........||......:.||.|::...||..|.
Yeast    14 HQKTPKLTLPVNLVQN------AKSTNDGQHLNRSPYSSVNESPYSNNSTSATSTTSSMASN--- 69

  Fly   162 DALEEVFKELKTNLEHRETLKAAPQEPPPVPPKKSPHTIPPKPQIKPKPRVTQK-----FSRTSD 221
                   ..|..|.....|:|..| .|||:||..                :|||     :....|
Yeast    70 -------STLLYNRSSTTTIKNRP-VPPPLPPLV----------------LTQKKDGIEYRVAGD 110

  Fly   222 IRRDEDSDNQH----------------KI-NTDTIIIKPAVGAQDAGADDNPDETILR----RSK 265
            .:..|...|.|                |: |.||..||..:...: |.|..| .|:|.    .|.
Yeast   111 SQLSERFSNLHVDITYKELLSSAPISTKLSNIDTTFIKKDLDTPE-GEDSYP-STLLSAYDFSSS 173

  Fly   266 EKRAQKTDAEIYVELRAICNSDDP-------------RERYKTTQEVGKGASGIVFIAADLQNES 317
            ...:....|...:....:....|.             ::...|...:|:||.|.| ....|:|..
Yeast   174 GSNSAPLSANNIISCSNLIQGKDVDQLEEEAWRFGHLKDEITTLGILGEGAGGSV-AKCRLKNGK 237

  Fly   318 QV-AVKTIDMKNQSS--KDLILTEIRVLKDFNHKNLVNFLDAYLLEPEDQLWVVMEYMDGGPLTD 379
            :| |:|||:..|...  :..|..|::..|.|....:|.:...:..|....:::.|||| ||...:
Yeast   238 KVFALKTINTMNTDPEYQKQIFRELQFNKSFKSDYIVQYYGMFTDEQSSSIYIAMEYM-GGKSLE 301

  Fly   380 VVTETVMK------ERQIACVCRETLYAISFLHAKGIIHRDIKSDNVLLGMDGSVKVTDFGFCAN 438
            ...:.::|      ||.|..:....|..:|:||.:.:||||||..|:||...|.:|:.|||
Yeast   302 ATYKNLLKRGGRISERVIGKIAESVLRGLSYLHERKVIHRDIKPQNILLNEKGEIKLCDFG---- 362

  Fly   439 IEGD---EKRQTMVGTPYWMAPEVVTRKKYGKKVDIWSIGIMAIEMIEGQPPYLYE------TPL 494
            :.|:   ....|..||.::||||.:..:.|....|:||:|:..:|:..|:.|:..:      .|:
Yeast   363 VSGEAVNSLAMTFTGTSFYMAPERIQGQPYSVTCDVWSLGLTLLEVAGGRFPFESDKITQNVAPI 427

  Fly   495 RALYLIAANGRPDIK-------SWDKLSPNLQDFLDRCLQVEVDRRATADELLSHPFLNDCSEVK 552
            ..|.:|.... |.:|       ||.|   ..:.|:|.||:.:...|.:..::|.||::  ..::|
Yeast   428 ELLTMILTFS-PQLKDEPELDISWSK---TFRSFIDYCLKKDARERPSPRQMLKHPWI--VGQMK 486

  Fly   553 ALVPNIKAAKK 563
            ..|...:..||
Yeast   487 KKVNMERFVKK 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak3	NP_001262638.1	PBD	19..73	CDD:279166
		PKc_like	288..545	CDD:304357	81/294 (28%)
		S_TKc	293..545	CDD:214567	80/276 (29%)
MKK2	NP_015185.1	PKc_Pek1_like	212..499	CDD:270793	84/298 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910