Protein Alignment Pak3 and CLA4

DIOPT Version :9

• Sequence 1: NP_001262638.1
• Gene: Pak3 / 41995
• FlyBaseID: FBgn0044826
• Length: 583
• Species: Drosophila melanogaster
• Sequence 2: NP_014101.1
• Gene: CLA4 / 855418
• SGDID: S000005242
• Length: 842
• Species: Saccharomyces cerevisiae
• Alignment Length: 660
• Identity: 217/660 - (32%)
• Similarity: 319/660 - (48%)
• Gaps: 128/660 - (19%)

  Fly    17 ISEIGAPTNFQRHFHVSRNQETGDLEGLPAPWVRLM-NSQITRDEQDKNPDAAYHAVKYY-NYS- 78
            :|.:.:||||....||..:.|||...|:|..|.:|: :|:||.::.:.|..|....:::| .|:
Yeast   181 LSGVSSPTNFTHKVHVGFDPETGSFVGMPTNWEKLLKHSRITGEDWNNNSAAVIQVLQFYQEYNG 245

  Fly    79 IKKKENEVFKPFITEDVIHEESKEIEN-YVNYKNKHKSQDPEKSDDDGSSTATETESSSGCGS-- 140
            .....|.:.||...|  .....|.:.| |.:.|.::.|.:.:.|....||..::.::|....:
Yeast   246 AGNPTNTLDKPQSGE--TSSSQKSLPNSYNDNKLRNNSVNSKSSSGVSSSMVSQRKTSQPPNTKS 308

  Fly   141 --SAGNSNSSSINDS--SQQSTVPLDALEEV-----------------------------FKELK 172
              |.|:.:...||..  :.||.:|.. |:.|                             .:.|:
Yeast   309 PVSLGSGSLPPINTKLPTSQSNIPRH-LQNVPNQQYPKMRNGHSPTNGQFPRGPMHPNNSQRSLQ 372

  Fly   173 TNLEHRETLKAAPQE---------------PPPVPPKKSPHTI-------PPKP------QIKPK 209
            ...:.::..|...|:               |.|:.|.:..|.:       |..|      |.:..
Yeast   373 QQQQQQQQQKQQHQQYPYHHQGPSPSPSPSPSPLNPYRPHHNMINPYSKQPQSPLSSQSTQNQAI 437

  Fly   210 PRVTQKFSRTS--------------DIRRDEDSDNQHKINTDTIIIKPAVGAQDAG-------AD 253
            ||..|..|.|:              ...|.....||:.  |....::|.....|..       |.
Yeast   438 PRYAQNSSPTAAHFQPQRTAPKPPISAPRAPYPSNQNA--TSNTHVQPVAPKNDQSTPQTMRQAP 500

  Fly   254 DNPDET------ILRRSKEKRAQKTDAEIYVELRAICNSDDPRERYKTTQEVGKGASGIVFIA-- 310
            ..||..      :.:..|..|...:.|||..:|:.:..:.||.:.:|..::.|:||||.|::|
Yeast   501 KRPDADVAQPGGVAKPKKPARPTMSTAEIMSKLKKVTVNADPSQCFKVIEKAGQGASGSVYLAER 565

  Fly   311 ADLQNES-----------------QVAVKTIDMKNQSSKDLILTEIRVLKDFNHKNLVNFLDAYL 358
            ..:..||                 :||:|.:.:..|..|:||:.||.|:||..|||:||||:||
Yeast   566 THIPTESNMIELINNDIDEPHVGDKVAIKQMVLSKQPRKELIVNEILVMKDSRHKNIVNFLEAY- 629

  Fly   359 LEPEDQLWVVMEYMDGGPLTDVV--------TETVMKERQIACVCRETLYAISFLHAKGIIHRDI 415
            |..:|.||||||:|:||.|||::        :.:.:.|.|||.:.|||...:.|||.|.||||||
Yeast   630 LRTDDDLWVVMEFMEGGSLTDIIENSPTNDNSHSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDI 694

  Fly   416 KSDNVLLGMDGSVKVTDFGFCANI-EGDEKRQTMVGTPYWMAPEVVTRKKYGKKVDIWSIGIMAI 479
            |||||||.....||:|||||||.: :...||.||||||||||||||.:::|.:|:|:||:|||.|
Yeast   695 KSDNVLLDTRARVKITDFGFCARLTDKRSKRATMVGTPYWMAPEVVKQREYDEKIDVWSLGIMTI 759

  Fly   480 EMIEGQPPYLYETPLRALYLIAANGRPDIKSWDKLSPNLQDFLDRCLQVEVDRRATADELLSHPF 544
            ||:||:||||.|.||:||||||.||.|.:|..:.||..::.||..||.|:|..||:.:|||.|.|
Yeast   760 EMLEGEPPYLNEDPLKALYLIATNGTPKLKHPESLSLEIKRFLSVCLCVDVRYRASTEELLHHGF 824

  Fly   545 LNDCSEVKAL 554
            .|...:.|.|
Yeast   825 FNMACDPKDL 834

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pak3	NP_001262638.1	PBD	19..73	CDD:279166	18/54 (33%)
		PKc_like	288..545	CDD:304357	140/284 (49%)
		S_TKc	293..545	CDD:214567	138/279 (49%)
CLA4	NP_014101.1	PH_Cla4_Ste20	62..174	CDD:270097
		PBD	183..241	CDD:395634	18/57 (32%)
		STKc_PAK	546..826	CDD:270789	139/280 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0578
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100484
Panther	1	1.100	-	-	O	PTHR48015
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.770