Protein Alignment Pak3 and SSK22

DIOPT Version :10

• Sequence 1: NP_001262638.1
• Gene: Pak3 / 41995
• FlyBaseID: FBgn0044826
• Length: 583
• Species: Drosophila melanogaster
• Sequence 2: NP_009998.2
• Gene: SSK22 / 850436
• SGDID: S000000669
• Length: 1331
• Species: Saccharomyces cerevisiae
• Alignment Length: 375
• Identity: 100/375 - (26%)
• Similarity: 174/375 - (46%)
• Gaps: 66/375 - (17%)

  Fly   226 EDSDNQHKINTDTIIIKPAVGAQDAGADDNPDE-------TILRRSKEKRAQKTDAEIYVELRAI 283
            |:...|.::|.||              ::|.||       :.||....|..:||......::..:
Yeast   959 ENGMQQARLNIDT--------------EENIDEEATLEINSRLRLEAIKTLEKTMKRNPRQMGKV 1009

  Fly   284 CNSDDPRERY---------------KTTQEVGKGASGIVFIAADLQNESQVAVKTIDMKNQSSK- 332
            .::.|...:|               :....:|.|..|.|:.|.:|:|...:|||.|.:.:.::.
Yeast  1010 LDATDQGNKYLLSLASSLSNVSMRWQKRSFIGGGTFGQVYSAINLENGEILAVKEIKIHDTTTMK 1074

  Fly   333 ---DLILTEIRVLKDFNHKNLVNFLDAYLLE-PEDQLWVVMEYMDGGPLTDVVTETVMKERQIAC 393
               .||..|:.||:..||.|:|.:   |.:| ..|::.:.|||.:||.|..::....:::..:..
Yeast  1075 KIFPLIKEEMTVLEMLNHPNIVQY---YGVEVHRDKVNIFMEYCEGGSLASLLDHGRIEDEMVTQ 1136

  Fly   394 VCR-ETLYAISFLHAKGIIHRDIKSDNVLLGMDGSVKVTDFGFCANIEGDEKR------------ 445
            |.. |.|..:::||..|::|||||.:|:||..:|.:|..|||....:.|...|
Yeast  1137 VYTFELLEGLAYLHQSGVVHRDIKPENILLDFNGIIKYVDFGTARTVVGSRTRTVRNAAVQDFGV 1201

  Fly   446 -----QTMVGTPYWMAPEVVTRKKYGKKV---DIWSIGIMAIEMIEGQPPYL-YETPLRALYLIA 501
                 ..|:|||.:||||.::......|:   |:|::|.:.:||..|:.|:. .:.....:|.:|
Yeast  1202 ETKSLNEMMGTPMYMAPETISGSAVKGKLGADDVWALGCVVLEMATGRRPWSNLDNEWAIMYHVA 1266

  Fly   502 ANGRPDIKSWDKLSPNLQDFLDRCLQVEVDRRATADELLSHPFLNDCSEV 551
            |...|.:.:.|:::...:.||:|||..:...||||.|||..|::....|:
Yeast  1267 AGRIPQLPNRDEMTAAGRAFLERCLVQDPTMRATAVELLIDPWMIQIREI 1316

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pak3	NP_001262638.1	PBD	19..76	CDD:395634
		Protein Kinases, catalytic domain	288..545	CDD:473864	86/298 (29%)
SSK22	NP_009998.2	STKc_MEKK4	1033..1309	CDD:270796	83/278 (30%)