DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pak3 and MAPKKK5

DIOPT Version :9

Sequence 1:	NP_001262638.1	Gene:	Pak3 / 41995	FlyBaseID:	FBgn0044826	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_569040.1	Gene:	MAPKKK5 / 836819	AraportID:	AT5G66850	Length:	716	Species:	Arabidopsis thaliana

Alignment Length:	574	Identity:	139/574 - (24%)
Similarity:	222/574 - (38%)	Gaps:	143/574 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 IENYVNYKN-KHKSQDPEKSDDDGSSTA---------------TETESSSGCGSSAGNSNSSSIN 151
            |.|..|.:. ..:.:|||:...|.:|:.               ..||:||....|..|.|...:|
plant   116 IRNAANARGLDDRDRDPERLISDRTSSGPPLTSVNGGFARDSRKATENSSYQDFSPRNRNGYWVN 180

  Fly   152 -------DSSQQSTVPLDALEEVFKEL-------KTNLEHRETLKAAPQE-------PPPV---- 191
                   .|...|.||....:....:|       |:|     ...:||..       |||.
plant   181 IPTMSAPTSPYMSPVPSPQRKSTGHDLPFFYLPPKSN-----QAWSAPDMPLDTSGLPPPAFYDI 240

  Fly   192 -------PPKKSPHTIPPKPQIK-PKPRVTQKFSR---------TSDIRRDEDSDNQH-KINTDT 238
                   .|..||....|:.||: |:|      ||         :|...||..|...| :::||.
plant   241 TAFSTDNSPIHSPQPRSPRKQIRSPQP------SRPSSPLHSVDSSAPPRDSVSSPLHPRLSTDV 299

  Fly   239 ------------IIIKPAVGAQDAGADDNPDETILRRSKEKRAQKTDAEIYVELRAICNSDDPRE 291
                        :.:.|......:.|...|        ..:...|.|            |.....
plant   300 TNGRRDCCNVHPLPLPPGATCSSSSAASVP--------SPQAPLKLD------------SFPMNS 344

  Fly   292 RYKTTQEVGKGASGIVFIAADLQNESQVAVKTI-----DMKNQSSKDLILTEIRVLKDFNHKNLV 351
            ::|..:.:|:|..|.|::|::.:..:..|:|.:     |.|:......:..||::|.:..|.|:|
plant   345 QWKKGKLIGRGTFGSVYVASNSETGALCAMKEVELFPDDPKSAECIKQLEQEIKLLSNLQHPNIV 409

  Fly   352 NFLDAYLLEPEDQLWVVMEYMDGGPLTDVVTE--TVMKERQIACVCRETLYAISFLHAKGIIHRD 414
            .:..:..:  ||:.::.:||:..|.:...:.:  ..|.|..:....|..|..:::||.|..:|||
plant   410 QYFGSETV--EDRFFIYLEYVHPGSINKYIRDHCGTMTESVVRNFTRHILSGLAYLHNKKTVHRD 472

  Fly   415 IKSDNVLLGMDGSVKVTDFGFCANIEGDEKRQTMVGTPYWMAPEVV-------TRKKYGKKVDIW 472
            ||..|:|:...|.||:.|||...::.|.....::.|:|||||||::       :.......||||
plant   473 IKGANLLVDASGVVKLADFGMAKHLTGQRADLSLKGSPYWMAPELMQAVMQKDSNPDLAFAVDIW 537

  Fly   473 SIGIMAIEMIEGQPPYLYETPLRALYLIAANGRPDIKSWDKLSPNLQDFLDRCLQVEVDRRATAD 537
            |:|...|||..|:||:.......|::.:..:..|..:|   :||..:|||..|.|.....|.||.
plant   538 SLGCTIIEMFTGKPPWSEFEGAAAMFKVMRDSPPIPES---MSPEGKDFLRLCFQRNPAERPTAS 599

  Fly   538 ELLSHPFLNDC--------SEVKALV--------------PNIKAAKKVLRRNV 569
            .||.|.||.:.        |:|..|.              ||.|..:....||:
plant   600 MLLEHRFLKNSLQPTSPSNSDVSQLFNGMNITEPSSRREKPNFKLDQVPRARNM 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak3	NP_001262638.1	PBD	19..73	CDD:279166
		PKc_like	288..545	CDD:304357	78/270 (29%)
		S_TKc	293..545	CDD:214567	78/265 (29%)
MAPKKK5	NP_569040.1	PKc_like	346..607	CDD:419665	78/265 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I1808
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.960