DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pak3 and S6K2

DIOPT Version :9

Sequence 1:	NP_001262638.1	Gene:	Pak3 / 41995	FlyBaseID:	FBgn0044826	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_001327294.1	Gene:	S6K2 / 820019	AraportID:	AT3G08720	Length:	471	Species:	Arabidopsis thaliana

Alignment Length:	465	Identity:	119/465 - (25%)
Similarity:	200/465 - (43%)	Gaps:	90/465 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   135 SSGCGSSAGNSNSS--------SINDSSQQSTVPLDALEEVFKEL-----KTNLEHRETLKAAPQ 186
            ||.|  |..|.|.:        |::.|..:|.:. |.||..|.::     :.|.|  |....|..
plant     3 SSQC--SVANKNQTGKPFQKHLSLSISPPKSVLG-DNLELQFSDVFGPMPEANSE--EACDVAYD 62

  Fly   187 EPPPVPPKKSPHTIPPKPQIKPKPRVTQKFSRTS-DIRRDEDSDNQHKINTDTIIIKPAVGAQD- 249
            ||..|..:.  |::     :.|...|:....... .:|..|||     ::....:...::...|
plant    63 EPAVVYSRS--HSL-----VGPSLVVSHSLKMNKLTLRETEDS-----VDLVECVEGESIKENDE 115

  Fly   250 -AGADDNPDETILRRSKEKRAQKTDAEIYVELRAICNSDDPRERYKTTQEVGKGASGIVFIAADL 313
             :|.||...|    :|.|            |:..:...:|    ::..:.||:||.|.|:.....
plant   116 FSGNDDTDSE----KSPE------------EVSGVVGIED----FEVLKVVGQGAFGKVYQVRKK 160

  Fly   314 QNESQVAVKT-----IDMKNQSSKDLILTEIRVLKDFNHKNLVNFLDAYLLEPEDQLWVVMEYMD 373
            ......|:|.     |..||.:  :.:..|..:|...:|..:|..  .|..:.:.:|::|:::::
plant   161 DTSEIYAMKVMRKDKIVEKNHA--EYMKAERDILTKIDHPFIVQL--KYSFQTKYRLYLVLDFIN 221

  Fly   374 GGPL-TDVVTETVMKERQIACVCRETLYAISFLHAKGIIHRDIKSDNVLLGMDGSVKVTDFGFCA 437
            ||.| ..:..:.:.:|........|.:.|:|.||.|||:|||:|.:|:|:.:||.|.:||||...
plant   222 GGHLFFQLYHQGLFREDLARVYTAEIVSAVSHLHEKGIMHRDLKPENILMDVDGHVMLTDFGLAK 286

  Fly   438 NIEGDEKRQTMVGTPYWMAPEVVTRKKYGKKVDIWSIGIMAIEMIEGQPPYLYETPLRALYLIAA 502
            ..|.:.:..:|.||..:||||:|..|.:.|..|.||:||:..||:.|:||:|           .:
plant   287 EFEENTRSNSMCGTTEYMAPEIVRGKGHDKAADWWSVGILLYEMLTGKPPFL-----------GS 340

  Fly   503 NG-------RPDIKSWDKLSPNLQDFLDRCLQVEVDRR-----ATADELLSHPFLNDCS----EV 551
            .|       :..||....||......|...||.|.:||     :.|:|:..|.:....:    |.
plant   341 KGKIQQKIVKDKIKLPQFLSNEAHALLKGLLQKEPERRLGSGPSGAEEIKKHKWFKAINWKKLEA 405

  Fly   552 KALVPNIKAA 561
            :.:.|:.|.|
plant   406 REVQPSFKPA 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak3	NP_001262638.1	PBD	19..73	CDD:279166
		PKc_like	288..545	CDD:304357	80/274 (29%)
		S_TKc	293..545	CDD:214567	79/269 (29%)
S6K2	NP_001327294.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910