Protein Alignment Pak3 and tlk2

DIOPT Version :9

• Sequence 1: NP_001262638.1
• Gene: Pak3 / 41995
• FlyBaseID: FBgn0044826
• Length: 583
• Species: Drosophila melanogaster
• Sequence 2: NP_001072711.1
• Gene: tlk2 / 780168
• XenbaseID: XB-GENE-5747259
• Length: 697
• Species: Xenopus tropicalis
• Alignment Length: 658
• Identity: 131/658 - (19%)
• Similarity: 220/658 - (33%)
• Gaps: 242/658 - (36%)

  Fly   111 NKHKSQDPEKSDDDGSS---TATETESSSG----------------CGSSAGNSNSSSINDSSQQ 156
            :|...|.|||..:|..:   .|...|:|.|                |||..|.|...|:...::.
 Frog    47 DKELEQTPEKKQNDQRNRKRKADPYETSQGKNTPRGHKISDYFEFACGSGPGTSPGRSVPPVARS 111

  Fly   157 STVPLDALEEVFKELKTNLEHRETLKAAPQEPPPVPPKKSPHTIPPKPQIKPKPRVTQ------- 214
            |.             :.:|.:...|.:....||...|....|:......|..:.|.||
 Frog   112 SP-------------QHSLSNPLPLPSQQCSPPSTAPVNPEHSCASFKHISVQHRCTQSDLTMDK 163

  Fly   215 ----KFSRTS-----------------DIRRDEDSD----------------------------- 229
                :.|::|                 |:||..|..
 Frog   164 ISALENSKSSDLEKKEGRIDDLLRVNCDLRRQMDEQKKMLEKYKERLNRCVTMSKKLLIEKSKQE 228

  Fly   230 ------------------------------------------NQHKINTDTIIIK---------- 242
                                                      .|.:|||....|:
 Frog   229 KMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQNLIKQQERINTQREEIERQRKMLAKRK 293

  Fly   243 -PAVGAQDAGADDNPDETILRRSKEKRAQ------------------------KTDAEIYV---- 278
             ||:| |...|::...:   |::|...|:                        |.:|||..
 Frog   294 PPAMG-QTPPANNEQKQ---RKNKTNGAENEALTLAEYHEQEEIFKLRLGHLKKEEAEIQAELER 354

  Fly   279 ----------ELRAICNSDDPR--------ERYKTTQEVGKGASGIVFIAADLQNESQVAVKT-- 323
                      ||:.|.|.|:.:        :||.....:|:|....|:.|.||..:..||||.
 Frog   355 LERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQ 419

  Fly   324 -----IDMKNQSSKDLILTEIRVLKDFNHKNLVNFLDAYLLEPEDQLWVVMEYMDGGPLTDVVTE 383
                 .|.|.::.......|.|:.|:.:|..:|...|.:.|: .|....|:||.:|..|...:.:
 Frog   420 LNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLD-TDSFCTVLEYCEGNDLDFYLKQ 483

  Fly   384 -TVMKERQIACVCRETLYAISFLH--AKGIIHRDIKSDNVLL---GMDGSVKVTDFGFCA----- 437
             .:|.|::...:..:.:.|:.:|:  ...|||.|:|..|:||   ...|.:|:||||...
 Frog   484 HKLMTEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDD 548

  Fly   438 ---NIEGDEKRQTMVGTPYWMAPE--VVTRK--KYGKKVDIWSIGIMAIEMIEGQPPY------- 488
               :::|.|......||.:::.||  ||.::  |...|||:||:|::..:.:.|:.|:
 Frog   549 SYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQ 613

  Fly   489 --LYETPLRALYLIAANGRPDIKSWDKLSPNLQDFLDRCLQVEVDRRATADELLSHPFLNDCSEV 551
              |.|..:.....:....:|.:      :|..:.|:.|||....:.|....:|...|:
 Frog   614 DILQENTILKATEVQFPPKPVV------TPEAKAFIRRCLAYRKEDRIDVQQLACDPY------- 665

  Fly   552 KALVPNIK 559
              |:|:|:
 Frog   666 --LLPHIR 671

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pak3	NP_001262638.1	PBD	19..73	CDD:279166
		PKc_like	288..545	CDD:304357	73/298 (24%)
		S_TKc	293..545	CDD:214567	72/285 (25%)
tlk2	NP_001072711.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	27..136		21/101 (21%)
		Smc	145..>385	CDD:224117	32/243 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	289..315		7/29 (24%)
		STKc_TLK2	380..688	CDD:270943	76/308 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910