DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pak3 and AURKC

DIOPT Version :9

Sequence 1:	NP_001262638.1	Gene:	Pak3 / 41995	FlyBaseID:	FBgn0044826	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_001015878.1	Gene:	AURKC / 6795	HGNCID:	11391	Length:	309	Species:	Homo sapiens

Alignment Length:	297	Identity:	81/297 - (27%)
Similarity:	145/297 - (48%)	Gaps:	34/297 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   268 RAQKTDAEIYVELRAICNSDDPRERYKTTQE------VGKGASGIVFIAADLQNESQVAVKTIDM 326
            :||....|:....:.......|..|..|..:      :|||..|.|::|...::...||:|.: .
Human    12 KAQPAGEELATANQTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVL-F 75

  Fly   327 KNQSSKD----LILTEIRVLKDFNHKNLVN----FLDAYLLEPEDQLWVVMEYMDGGPL-TDVVT 382
            |:|..|:    .:..||.:.....|.|::.    |.||      .::::::||...|.| .::..
Human    76 KSQIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDA------RRVYLILEYAPRGELYKELQK 134

  Fly   383 ETVMKERQIACVCRETLYAISFLHAKGIIHRDIKSDNVLLGMDGSVKVTDFGFCANIEGDEKRQT 447
            ...:.|::.|.:..|...|:::.|.|.:||||||.:|:|||..|.||:.|||:..:.. ..:|:|
Human   135 SEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTP-SLRRKT 198

  Fly   448 MVGTPYWMAPEVVTRKKYGKKVDIWSIGIMAIEMIEGQPPY----LYETPLRALYLIAANGRPDI 508
            |.||..::.||::..:.|.:|||:|.||::..|::.|.||:    ..||..|.|       :.|:
Human   199 MCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRIL-------KVDV 256

  Fly   509 KSWDKLSPNLQDFLDRCLQVEVDRRATADELLSHPFL 545
            :....:....:|.:.|.|:.:...|....::|.||::
Human   257 RFPLSMPLGARDLISRLLRYQPLERLPLAQILKHPWV 293

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak3	NP_001262638.1	PBD	19..73	CDD:279166
		PKc_like	288..545	CDD:304357	78/275 (28%)
		S_TKc	293..545	CDD:214567	76/270 (28%)
AURKC	NP_001015878.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33		3/20 (15%)
		STKc_Aurora-B_like	36..305	CDD:271019	77/273 (28%)
		S_TKc	43..293	CDD:214567	75/264 (28%)
		Interaction with BIRC5. /evidence=ECO:0000269\|PubMed:27332895	292..309		0/2 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910