DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pak3 and TAOK1

DIOPT Version :9

Sequence 1:	NP_001262638.1	Gene:	Pak3 / 41995	FlyBaseID:	FBgn0044826	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_065842.1	Gene:	TAOK1 / 57551	HGNCID:	29259	Length:	1001	Species:	Homo sapiens

Alignment Length:	296	Identity:	100/296 - (33%)
Similarity:	159/296 - (53%)	Gaps:	15/296 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   279 ELRAICNSDDPRERYKTTQEVGKGASGIVFIAADLQNESQVAVKTIDMKNQSSKDL---ILTEIR 340
            |:..:...:||.:.:...:|:|.|:.|.|:.|.|::....||:|.:....:.|.:.   |:.|::
Human    14 EIAELFFKEDPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQSTEKWQDIIKEVK 78

  Fly   341 VLKDFNHKNLVNFLDAYLLEPEDQLWVVMEYMDGGPLTDV--VTETVMKERQIACVCRETLYAIS 403
            .|:...|.|.:.:...||  .|...|:||||..|. .:|:  |.:..::|.:||.:....|..::
Human    79 FLQRIKHPNSIEYKGCYL--REHTAWLVMEYCLGS-ASDLLEVHKKPLQEVEIAAITHGALQGLA 140

  Fly   404 FLHAKGIIHRDIKSDNVLLGMDGSVKVTDFGFCANIEGDEKRQTMVGTPYWMAPEVV---TRKKY 465
            :||:..:||||||:.|:||...|.||:.|||..:..   ....:.|||||||||||:   ...:|
Human   141 YLHSHTMIHRDIKAGNILLTEPGQVKLADFGSASMA---SPANSFVGTPYWMAPEVILAMDEGQY 202

  Fly   466 GKKVDIWSIGIMAIEMIEGQPPYLYETPLRALYLIAANGRPDIKSWDKLSPNLQDFLDRCLQVEV 530
            ..|||:||:||..||:.|.:||......:.|||.||.|..|.::| ::.|...::|:|.|||...
Human   203 DGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPTLQS-NEWSDYFRNFVDSCLQKIP 266

  Fly   531 DRRATADELLSHPFLNDCSEVKALVPNIKAAKKVLR 566
            ..|.|::|||.|.|:........|:..|:..|..:|
Human   267 QDRPTSEELLKHIFVLRERPETVLIDLIQRTKDAVR 302

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pak3	NP_001262638.1	PBD	19..73	CDD:279166
		PKc_like	288..545	CDD:304357	94/264 (36%)
		S_TKc	293..545	CDD:214567	92/259 (36%)
TAOK1	NP_065842.1	STKc_TAO1	2..318	CDD:270805	100/296 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	324..433
		SbcC	<442..>877	CDD:223496
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	567..587
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	911..1001
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910